Pathogenesis of Insulin Resistance in Skeletal Muscle

by Muhammad A. Abdul-Ghani, Ralph A. DeFronzo
Published 2010-01-01

Pioglitazone and alogliptin combination therapy in type 2 diabetes: a pathophysiologically sound treatment

by Curtis Triplitt, Eugenio Cersosimo, Ralph A DeFronzo
Published 2010-08-01

Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease

by Amalia Gastaldelli, Elisabetta Bugianesi, Ralph A. DeFronzo, Melania Gaggini, Mariangela Morelli, Emma Buzzigoli
Published 2013-05-01

Increased lipid availability for three days reduces whole body glucose uptake, impairs muscle mitochondrial function and initiates opposing effects on PGC-1α promoter methylation i...

by Roy Eldor, Luke Norton, Marcel Fourcaudot, Cynthia Galindo, Ralph A DeFronzo, Muhammad Abdul-Ghani
Published 2017-01-01

Mechanism of Action of Inhaled Insulin on Whole Body Glucose Metabolism in Subjects with Type 2 Diabetes Mellitus

by Rucha J. Mehta, Amalia Gastaldelli, Bogdana Balas, Andrea Ricotti, Ralph A. DeFronzo, Devjit Tripathy
Published 2019-08-01

Short-Term Exercise Training Improves Insulin Sensitivity but Does Not Inhibit Inflammatory Pathways in Immune Cells from Insulin-Resistant Subjects

by Sara M. Reyna, Puntip Tantiwong, Eugenio Cersosimo, Ralph A. DeFronzo, Apiradee Sriwijitkamol, Nicolas Musi
Published 2013-01-01

The Impact of Vitamin D Deficiency on Retinopathy and Hearing Loss among Type 2 Diabetic Patients

by Abdulbari Bener, Mustafa Eliaçık, Hakan Cincik, Mustafa Öztürk, Ralph A. DeFronzo, Muhammad Abdul-Ghani
Published 2018-01-01

Transcriptomics in type 2 diabetes: Bridging the gap between genotype and phenotype

by Christopher P. Jenkinson, Harald H.H. Göring, Rector Arya, John Blangero, Ravindranath Duggirala, Ralph A. DeFronzo
Published 2016-06-01

From glucose lowering agents to disease/diabetes modifying drugs: a “SIMPLE” approach for the treatment of type 2 diabetes

by Ofri Mosenzon, Stefano Del Prato, Meir Schechter, Lawrence A. Leiter, Antonio Ceriello, Ralph A. DeFronzo, Itamar Raz
Published 2021-04-01

Glycated hemoglobin versus oral glucose tolerance test in the identification of subjects with prediabetes in Qatari population

by Saadallah Iskandar, Ayman Migahid, Dalia Kamal, Osama Megahed, Ralph A. DeFronzo, Mahmoud Zirie, Amin Jayyousi, Mahmood Al Jaidah, Muhammad Abdul-Ghani
Published 2019-08-01

Effects of intravenous AICAR (5-aminoimidazole-4-carboximide riboside) administration on insulin signaling and resistance in premature baboons, Papio sp.

by Cynthia L Blanco, Amalia Gastaldelli, Diana G Anzueto, Lauryn A Winter, Steven R Seidner, Donald C McCurnin, Hanyu Liang, Martin A Javors, Ralph A DeFronzo, Nicolas Musi
Published 2018-01-01

Does reduced IGF-1R signaling in Igf1r+/- mice alter aging?

by Alex F Bokov, Neha Garg, Yuji Ikeno, Sachin Thakur, Nicolas Musi, Ralph A DeFronzo, Ning Zhang, Rebecca C Erickson, Jon Gelfond, Gene B Hubbard, Martin L Adamo, Arlan Richardson
Published 2011-01-01

Proximal tubular epithelial insulin receptor mediates high-fat diet–induced kidney injury

by Hak Joo Lee, Meenalakshmi M. Mariappan, Luke Norton, Terry Bakewell, Denis Feliers, Sae Byeol Oh, Andrew Donati, Cherubina S. Rubannelsonkumar, Manjeri A. Venkatachalam, Stephen E. Harris, Isabelle Rubera, Michel Tauc, Goutam Ghosh Choudhury, C. Ronald Kahn, Kumar Sharma, Ralph A. DeFronzo, Balakuntalam S. Kasinath
Published 2021-02-01

APPL1 Potentiates Insulin Sensitivity by Facilitating the Binding of IRS1/2 to the Insulin Receptor

by Jiyoon Ryu, Amanda K. Galan, Xiaoban Xin, Feng Dong, Muhammad A. Abdul-Ghani, Lijun Zhou, Changhua Wang, Cuiling Li, Bekke M. Holmes, Lauren B. Sloane, Steven N. Austad, Shaodong Guo, Nicolas Musi, Ralph A. DeFronzo, Chuxia Deng, Morris F. White, Feng Liu, Lily Q. Dong
Published 2014-05-01

Serum carotenoids and Pediatric Metabolic Index predict insulin sensitivity in Mexican American children

by Srinivas Mummidi, Vidya S. Farook, Lavanya Reddivari, Joselin Hernandez-Ruiz, Alvaro Diaz-Badillo, Sharon P. Fowler, Roy G. Resendez, Feroz Akhtar, Donna M. Lehman, Christopher P. Jenkinson, Rector Arya, Jane L. Lynch, Jose A. Canas, Ralph A. DeFronzo, Daniel E. Hale, John Blangero, Juan Carlos Lopez-Alvarenga, Ravindranath Duggirala, Jairam K. P. Vanamala
Published 2021-01-01

Acanthosis nigricans as a composite marker of cardiometabolic risk and its complex association with obesity and insulin resistance in Mexican American children.

by Juan C Lopez-Alvarenga, Geetha Chittoor, Solomon F D Paul, Sobha Puppala, Vidya S Farook, Sharon P Fowler, Roy G Resendez, Joselin Hernandez-Ruiz, Alvaro Diaz-Badillo, David Salazar, Doreen D Garza, Donna M Lehman, Srinivas Mummidi, Rector Arya, Christopher P Jenkinson, Jane L Lynch, Ralph A DeFronzo, John Blangero, Daniel E Hale, Ravindranath Duggirala
Published 2020-01-01

Transcriptomic identification of ADH1B as a novel candidate gene for obesity and insulin resistance in human adipose tissue in Mexican Americans from the Veterans Administration Ge...

by Deidre A Winnier, Marcel Fourcaudot, Luke Norton, Muhammad A Abdul-Ghani, Shirley L Hu, Vidya S Farook, Dawn K Coletta, Satish Kumar, Sobha Puppala, Geetha Chittoor, Thomas D Dyer, Rector Arya, Melanie Carless, Donna M Lehman, Joanne E Curran, Douglas T Cromack, Devjit Tripathy, John Blangero, Ravindranath Duggirala, Harald H H Göring, Ralph A DeFronzo, Christopher P Jenkinson
Published 2015-01-01

Coordinated defects in hepatic long chain fatty acid metabolism and triglyceride accumulation contribute to insulin resistance in non-human primates.

by Subhash Kamath, Alberto O Chavez, Amalia Gastaldelli, Francesca Casiraghi, Glenn A Halff, Gregory A Abrahamian, Alberto M Davalli, Raul A Bastarrachea, Anthony G Comuzzie, Rodolfo Guardado-Mendoza, Lilia M Jimenez-Ceja, Vicki Mattern, Ana Maria Paez, Andrea Ricotti, Mary E Tejero, Paul B Higgins, Iram Pablo Rodriguez-Sanchez, Devjit Tripathy, Ralph A DeFronzo, Edward J Dick, Gary W Cline, Franco Folli
Published 2011-01-01

Further evidence supporting a potential role for ADH1B in obesity

by Liza D. Morales, Douglas T. Cromack, Devjit Tripathy, Marcel Fourcaudot, Satish Kumar, Joanne E. Curran, Melanie Carless, Harald H. H. Göring, Shirley L. Hu, Juan Carlos Lopez-Alvarenga, Kristina M. Garske, Päivi Pajukanta, Kerrin S. Small, Craig A. Glastonbury, Swapan K. Das, Carl Langefeld, Robert L. Hanson, Wen-Chi Hsueh, Luke Norton, Rector Arya, Srinivas Mummidi, John Blangero, Ralph A. DeFronzo, Ravindranath Duggirala, Christopher P. Jenkinson
Published 2021-01-01

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

by Julia K. Goodrich, Moriel Singer-Berk, Rachel Son, Abigail Sveden, Jordan Wood, Eleina England, Joanne B. Cole, Ben Weisburd, Nick Watts, Lizz Caulkins, Peter Dornbos, Ryan Koesterer, Zachary Zappala, Haichen Zhang, Kristin A. Maloney, Andy Dahl, Carlos A. Aguilar-Salinas, Gil Atzmon, Francisco Barajas-Olmos, Nir Barzilai, John Blangero, Eric Boerwinkle, Lori L. Bonnycastle, Erwin Bottinger, Donald W. Bowden, Federico Centeno-Cruz, John C. Chambers, Nathalie Chami, Edmund Chan, Juliana Chan, Ching-Yu Cheng, Yoon Shin Cho, Cecilia Contreras-Cubas, Emilio Córdova, Adolfo Correa, Ralph A. DeFronzo, Ravindranath Duggirala, Josée Dupuis, Ma Eugenia Garay-Sevilla, Humberto García-Ortiz, Christian Gieger, Benjamin Glaser, Clicerio González-Villalpando, Ma Elena Gonzalez, Niels Grarup, Leif Groop, Myron Gross, Christopher Haiman, Sohee Han, Craig L. Hanis, Torben Hansen, Nancy L. Heard-Costa, Brian E. Henderson, Juan Manuel Malacara Hernandez, Mi Yeong Hwang, Sergio Islas-Andrade, Marit E. Jørgensen, Hyun Min Kang, Bong-Jo Kim, Young Jin Kim, Heikki A. Koistinen, Jaspal Singh Kooner, Johanna Kuusisto, Soo-Heon Kwak, Markku Laakso, Leslie Lange, Jong-Young Lee, Juyoung Lee, Donna M. Lehman, Allan Linneberg, Jianjun Liu, Ruth J. F. Loos, Valeriya Lyssenko, Ronald C. W. Ma, Angélica Martínez-Hernández, James B. Meigs, Thomas Meitinger, Elvia Mendoza-Caamal, Karen L. Mohlke, Andrew D. Morris, Alanna C. Morrison, Maggie C. Y. Ng, Peter M. Nilsson, Christopher J. O’Donnell, Lorena Orozco, Colin N. A. Palmer, Kyong Soo Park, Wendy S. Post, Oluf Pedersen, Michael Preuss, Bruce M. Psaty, Alexander P. Reiner, Cristina Revilla-Monsalve, Stephen S. Rich, Jerome I. Rotter, Danish Saleheen, Claudia Schurmann, Xueling Sim, Rob Sladek, Kerrin S. Small, Wing Yee So, Timothy D. Spector, Konstantin Strauch, Tim M. Strom, E. Shyong Tai, Claudia H. T. Tam, Yik Ying Teo, Farook Thameem, Brian Tomlinson, Russell P. Tracy, Tiinamaija Tuomi, Jaakko Tuomilehto, Teresa Tusié-Luna, Rob M. van Dam, Ramachandran S. Vasan, James G. Wilson, Daniel R. Witte, Tien-Yin Wong, AMP-T2D-GENES Consortia, Noël P. Burtt, Noah Zaitlen, Mark I. McCarthy, Michael Boehnke, Toni I. Pollin, Jason Flannick, Josep M. Mercader, Anne O’Donnell-Luria, Samantha Baxter, Jose C. Florez, Daniel G. MacArthur, Miriam S. Udler
Published 2021-06-01