Distinct Spatiotemporal Distribution of Bacterial Toxin-Produced Cellular cAMP Differentially Inhibits Opsonophagocytic Signaling

by Shakir Hasan, Waheed Ur Rahman, Peter Sebo, Radim Osicka
Published 2019-06-01

Bordetella Pertussis Adenylate Cyclase Toxin Does Not Possess a Phospholipase A Activity; Serine 606 and Aspartate 1079 Residues Are Not Involved in Target Cell Delivery of the Ade...

by Ladislav Bumba, Jiri Masin, Adriana Osickova, Radim Osicka, Peter Sebo
Published 2018-06-01

Bordetella adenylate cyclase toxin is a unique ligand of the integrin complement receptor 3

by Radim Osicka, Adriana Osickova, Shakir Hasan, Ladislav Bumba, Jiri Cerny, Peter Sebo
Published 2015-12-01

Rapid Purification of Endotoxin-Free RTX Toxins

by Ondrej Stanek, Jiri Masin, Radim Osicka, David Jurnecka, Adriana Osickova, Peter Sebo
Published 2019-06-01

Simultaneous Determination of Antibodies to Pertussis Toxin and Adenylate Cyclase Toxin Improves Serological Diagnosis of Pertussis

by Aapo Knuutila, Alex-Mikael Barkoff, Jussi Mertsola, Radim Osicka, Peter Sebo, Qiushui He
Published 2021-01-01

Binding of <i>Kingella kingae</i> RtxA Toxin Depends on Cell Surface Oligosaccharides, but Not on β₂ Integrins

by Waheed Ur Rahman, Adriana Osickova, Nela Klimova, Jinery Lora, Nataliya Balashova, Radim Osicka
Published 2020-11-01

Structure–Function Relationships Underlying the Capacity of Bordetella Adenylate Cyclase Toxin to Disarm Host Phagocytes

by Jakub Novak, Ondrej Cerny, Adriana Osickova, Irena Linhartova, Jiri Masin, Ladislav Bumba, Peter Sebo, Radim Osicka
Published 2017-09-01

ABD-Derived Protein Blockers of Human IL-17 Receptor A as Non-IgG Alternatives for Modulation of IL-17-Dependent Pro-Inflammatory Axis

by Marie Hlavničková, Milan Kuchař, Radim Osička, Lucie Vaňková, Hana Petroková, Michal Malý, Jiří Černý, Petr Arenberger, Petr Malý
Published 2018-10-01

<i>Bordetella</i> Adenylate Cyclase Toxin Elicits Airway Mucin Secretion through Activation of the cAMP Response Element Binding Protein

by Anna Malandra, Waheed Ur Rahman, Nela Klimova, Gaia Streparola, Jana Holubova, Adriana Osickova, Simone Bariselli, Peter Sebo, Radim Osicka
Published 2021-08-01

Production of Highly Active Recombinant Dermonecrotic Toxin of <i>Bordetella Pertussis</i>

by Ondrej Stanek, Irena Linhartova, Jana Holubova, Ladislav Bumba, Zdenko Gardian, Anna Malandra, Barbora Bockova, Shihono Teruya, Yasuhiko Horiguchi, Radim Osicka, Peter Sebo
Published 2020-09-01

Different roles of conserved tyrosine residues of the acylated domains in folding and activity of RTX toxins

by Anna Lepesheva, Adriana Osickova, Jana Holubova, David Jurnecka, Sarka Knoblochova, Carlos Espinosa-Vinals, Ladislav Bumba, Karolina Skopova, Radovan Fiser, Radim Osicka, Peter Sebo, Jiri Masin
Published 2021-10-01

Cytotoxic activity of Kingella kingae RtxA toxin depends on post-translational acylation of lysine residues and cholesterol binding

by Adriana Osickova, Nataliya Balashova, Jiri Masin, Miroslav Sulc, Jana Roderova, Tomas Wald, Angela C. Brown, Evan Koufos, En Hyung Chang, Alexander Giannakakis, Edward T. Lally, Radim Osicka
Published 2018-11-01

Calcium influx rescues adenylate cyclase-hemolysin from rapid cell membrane removal and enables phagocyte permeabilization by toxin pores.

by Radovan Fiser, Jiri Masin, Ladislav Bumba, Eva Pospisilova, Catherine Fayolle, Marek Basler, Lenka Sadilkova, Irena Adkins, Jana Kamanova, Jan Cerny, Ivo Konopasek, Radim Osicka, Claude Leclerc, Peter Sebo
Published 2012-01-01