Reciprocal Degradation of YME1L and OMA1 Adapts Mitochondrial Proteolytic Activity during Stress

by T. Kelly Rainbolt, Justine Lebeau, Cristina Puchades, R. Luke Wiseman
Published 2016-03-01

Modulating protein quality control

by Lars Plate, Ryan J Paxman, R Luke Wiseman, Jeffery W Kelly
Published 2016-07-01

Defining the Functional Targets of Cap‘n’collar Transcription Factors NRF1, NRF2, and NRF3

by Lara Ibrahim, Jaleh Mesgarzadeh, Ian Xu, Evan T. Powers, R. Luke Wiseman, Michael J. Bollong
Published 2020-10-01

Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins

by Ryan Paxman, Lars Plate, Erik A Blackwood, Chris Glembotski, Evan T Powers, R Luke Wiseman, Jeffery W Kelly
Published 2018-08-01

The PERK Arm of the Unfolded Protein Response Regulates Mitochondrial Morphology during Acute Endoplasmic Reticulum Stress

by Justine Lebeau, Jaclyn M. Saunders, Vivian W.R. Moraes, Aparajita Madhavan, Nicole Madrazo, Mary C. Anthony, R. Luke Wiseman
Published 2018-03-01

Structures of the human LONP1 protease reveal regulatory steps involved in protease activation

by Mia Shin, Edmond R. Watson, Albert S. Song, Jeffrey T. Mindrebo, Scott J. Novick, Patrick R. Griffin, R. Luke Wiseman, Gabriel C. Lander
Published 2021-05-01

Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis

by Erik A. Blackwood, Khalid Azizi, Donna J. Thuerauf, Ryan J. Paxman, Lars Plate, Jeffery W. Kelly, R. Luke Wiseman, Christopher C. Glembotski
Published 2019-01-01

Premature Activation of Immune Transcription Programs in Autoimmune-Predisposed Mouse Embryonic Stem Cells and Blastocysts

by Oktay Kirak, Eugene Ke, Kevin Y. Yang, Anna Schwarz, Lars Plate, Amy Nham, Justin R. Abadejos, Anna Valencia, R. Luke Wiseman, Kathy O. Lui, Manching Ku
Published 2020-08-01

Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments

by Matthew D. Shoulders, Lisa M. Ryno, Joseph C. Genereux, James J. Moresco, Patricia G. Tu, Chunlei Wu, John R. Yates, III, Andrew I. Su, Jeffery W. Kelly, R. Luke Wiseman
Published 2013-04-01

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

by Lars Plate, Christina B Cooley, John J Chen, Ryan J Paxman, Ciara M Gallagher, Franck Madoux, Joseph C Genereux, Wesley Dobbs, Dan Garza, Timothy P Spicer, Louis Scampavia, Steven J Brown, Hugh Rosen, Evan T Powers, Peter Walter, Peter Hodder, R Luke Wiseman, Jeffery W Kelly
Published 2016-07-01