Broadly neutralizing antibodies: What is needed to move from a rare event in HIV-1 infection to vaccine efficacy?

by Harini Subbaraman, Merle Schanz, Alexandra Trkola
Published 2018-07-01

CD4 occupancy triggers sequential pre-fusion conformational states of the HIV-1 envelope trimer with relevance for broadly neutralizing antibody activity.

by Branislav Ivan, Zhaozhi Sun, Harini Subbaraman, Nikolas Friedrich, Alexandra Trkola
Published 2019-01-01

Different infectivity of HIV-1 strains is linked to number of envelope trimers required for entry.

by Oliver F Brandenberg, Carsten Magnus, Peter Rusert, Roland R Regoes, Alexandra Trkola
Published 2015-01-01

Immune senescence: relative contributions of age and cytomegalovirus infection.

by Andrea Mekker, Vincent S Tchang, Lea Haeberli, Annette Oxenius, Alexandra Trkola, Urs Karrer
Published 2012-01-01

Capacity of Broadly Neutralizing Antibodies to Inhibit HIV-1 Cell-Cell Transmission Is Strain- and Epitope-Dependent.

by Lucia Reh, Carsten Magnus, Merle Schanz, Jacqueline Weber, Therese Uhr, Peter Rusert, Alexandra Trkola
Published 2015-07-01

Predicting HIV-1 transmission and antibody neutralization efficacy in vivo from stoichiometric parameters.

by Oliver F Brandenberg, Carsten Magnus, Peter Rusert, Huldrych F Günthard, Roland R Regoes, Alexandra Trkola
Published 2017-05-01

Cell-cell transmission enables HIV-1 to evade inhibition by potent CD4bs directed antibodies.

by Irene A Abela, Livia Berlinger, Merle Schanz, Lucy Reynell, Huldrych F Günthard, Peter Rusert, Alexandra Trkola
Published 2012-01-01

High-throughput sequencing of human immunoglobulin variable regions with subtype identification.

by Merle Schanz, Thomas Liechti, Osvaldo Zagordi, Enkelejda Miho, Sai T Reddy, Huldrych F Günthard, Alexandra Trkola, Michael Huber
Published 2014-01-01

Do we cause false positives? An experimental series on droplet or airborne SARS-CoV-2 contamination of sampling tubes during swab collection in a test center

by Thomas Scheier, Cyril Shah, Michael Huber, Hugo Sax, Barbara Hasse, Huldrych F. Günthard, Alexandra Trkola, Peter W. Schreiber
Published 2021-03-01

In vivo binding and retention of CD4-specific DARPin 57.2 in macaques.

by Pavel Pugach, Anders Krarup, Agegnehu Gettie, Marcelo Kuroda, James Blanchard, Michael Piatak, Jeffrey D Lifson, Alexandra Trkola, Melissa Robbiani
Published 2010-08-01

Phenotypic deficits in the HIV-1 envelope are associated with the maturation of a V2-directed broadly neutralizing antibody lineage.

by Lucia Reh, Carsten Magnus, Claus Kadelka, Denise Kühnert, Therese Uhr, Jacqueline Weber, Lynn Morris, Penny L Moore, Alexandra Trkola
Published 2018-01-01

Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies

by Christophe Caillat, Delphine Guilligay, Johana Torralba, Nikolas Friedrich, Jose L Nieva, Alexandra Trkola, Christophe J Chipot, François L Dehez, Winfried Weissenhorn
Published 2021-04-01

Optimization and validation of sample preparation for metagenomic sequencing of viruses in clinical samples

by Dagmara W. Lewandowska, Osvaldo Zagordi, Fabienne-Desirée Geissberger, Verena Kufner, Stefan Schmutz, Jürg Böni, Karin J. Metzner, Alexandra Trkola, Michael Huber
Published 2017-08-01

Correction to: Optimization and validation of sample preparation for metagenomic sequencing of viruses in clinical samples

by Dagmara W. Lewandowska, Osvaldo Zagordi, Fabienne-Desirée Geissberger, Verena Kufner, Stefan Schmutz, Jürg Böni, Karin J. Metzner, Alexandra Trkola, Michael Huber
Published 2017-10-01

Complement lysis activity in autologous plasma is associated with lower viral loads during the acute phase of HIV-1 infection.

by Michael Huber, Marek Fischer, Benjamin Misselwitz, Amapola Manrique, Herbert Kuster, Barbara Niederöst, Rainer Weber, Viktor von Wyl, Huldrych F Günthard, Alexandra Trkola
Published 2006-11-01

Two Years of Viral Metagenomics in a Tertiary Diagnostics Unit: Evaluation of the First 105 Cases

by Verena Kufner, Andreas Plate, Stefan Schmutz, Dominique L. Braun, Huldrych F. Günthard, Riccarda Capaul, Andrea Zbinden, Nicolas J. Mueller, Alexandra Trkola, Michael Huber
Published 2019-08-01

CD4-specific designed ankyrin repeat proteins are novel potent HIV entry inhibitors with unique characteristics.

by Andreas Schweizer, Peter Rusert, Livia Berlinger, Claudia R Ruprecht, Axel Mann, Stéphanie Corthésy, Stuart G Turville, Meropi Aravantinou, Marek Fischer, Melissa Robbiani, Patrick Amstutz, Alexandra Trkola
Published 2008-07-01

Lower Broadly Neutralizing Antibody Responses in Female Versus Male HIV-1 Infected Injecting Drug Users

by Zelda EULER, Tom L. VAN DEN KERKHOF, Roger D. KOUYOS, Damien C. TULLY, Todd M. ALLEN, Alexandra TRKOLA, Rogier W. SANDERS, Hanneke SCHUITEMAKER, Marit J. VAN GILS
Published 2019-04-01

The TransFLUas influenza transmission study in acute healthcare - recruitment rates and protocol adherence in healthcare workers and inpatients

by Hila Schwarz, Jürg Böni, Roger D. Kouyos, Teja Turk, Edouard Battegay, Malcolm Kohler, Rouven Müller, Heidi Petry, Hugo Sax, Rainer Weber, Allison McGeer, Alexandra Trkola, Stefan P. Kuster
Published 2019-05-01

Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality.

by David Beauparlant, Peter Rusert, Carsten Magnus, Claus Kadelka, Jacqueline Weber, Therese Uhr, Osvaldo Zagordi, Corinna Oberle, Maria J Duenas-Decamp, Paul R Clapham, Karin J Metzner, Huldrych F Günthard, Alexandra Trkola
Published 2017-03-01