Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis

by Pedro H. V. Saavedra, Linyan Huang, Farzaneh Ghazavi, Stephanie Kourula, Tom Vanden Berghe, Nozomi Takahashi, Peter Vandenabeele, Mohamed Lamkanfi
Published 2018-11-01

Immunometabolism of Tissue-Resident Macrophages – An Appraisal of the Current Knowledge and Cutting-Edge Methods and Technologies

by Giulia Zago, Pedro H. V. Saavedra, Kayvan R. Keshari, Kayvan R. Keshari, Justin S. A. Perry, Justin S. A. Perry, Justin S. A. Perry
Published 2021-05-01

Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4

by Nina Van Opdenbosch, Hanne Van Gorp, Maarten Verdonckt, Pedro H.V. Saavedra, Nathalia M. de Vasconcelos, Amanda Gonçalves, Lieselotte Vande Walle, Dieter Demon, Magdalena Matusiak, Filip Van Hauwermeiren, Jinke D’Hont, Tino Hochepied, Stefan Krautwald, Thirumala-Devi Kanneganti, Mohamed Lamkanfi
Published 2017-12-01

MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition.

by Lieselotte Vande Walle, Irma B Stowe, Pavel Šácha, Bettina L Lee, Dieter Demon, Amelie Fossoul, Filip Van Hauwermeiren, Pedro H V Saavedra, Petr Šimon, Vladimír Šubrt, Libor Kostka, Craig E Stivala, Victoria C Pham, Steven T Staben, Sayumi Yamazoe, Jan Konvalinka, Nobuhiko Kayagaki, Mohamed Lamkanfi
Published 2019-09-01

Correction: MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition.

by Lieselotte Vande Walle, Irma B Stowe, Pavel Šácha, Bettina L Lee, Dieter Demon, Amelie Fossoul, Filip Van Hauwermeiren, Pedro H V Saavedra, Petr Šimon, Vladimír Šubr, Libor Kostka, Craig E Stivala, Victoria C Pham, Steven T Staben, Sayumi Yamazoe, Jan Konvalinka, Nobuhiko Kayagaki, Mohamed Lamkanfi
Published 2019-10-01

Cryptococcus neoformans Secretes Small Molecules That Inhibit IL-1β Inflammasome-Dependent Secretion

by Pedro Henrique Bürgel, Clara Luna Marina, Pedro H. V. Saavedra, Patrícia Albuquerque, Stephan Alberto Machado de Oliveira, Paulo Henrique de Holanda Veloso Janior, Raffael Araújo de Castro, Heino M. Heyman, Carolina Coelho, Radames J. B. Cordero, Arturo Casadevall, Joshua D. Nosanchuk, Ernesto S. Nakayasu, Robin C. May, Aldo Henrique Tavares, Anamelia Lorenzetti Bocca
Published 2020-01-01