Autophagy in Trypanosomatids

by Paul A. M. Michels, Eva Rico, Ana Brennand
Published 2012-07-01

A paradigm shift: The mitoproteomes of procyclic and bloodstream Trypanosoma brucei are comparably complex.

by Alena Zíková, Zdeněk Verner, Anna Nenarokova, Paul A M Michels, Julius Lukeš
Published 2017-12-01

Structure, Properties, and Function of Glycosomes in Trypanosoma cruzi

by Wilfredo Quiñones, Héctor Acosta, Camila Silva Gonçalves, Maria Cristina M. Motta, Melisa Gualdrón-López, Paul A. M. Michels
Published 2020-01-01

The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids

by Letícia Marchese, Janaina de Freitas Nascimento, Flávia Silva Damasceno, Frédéric Bringaud, Paul A. M. Michels, Ariel Mariano Silber
Published 2018-04-01

ATG24 Represses Autophagy and Differentiation and Is Essential for Homeostasy of the Flagellar Pocket in Trypanosoma brucei.

by Ana Brennand, Eva Rico, Daniel J Rigden, Patrick Van Der Smissen, Pierre J Courtoy, Paul A M Michels
Published 2015-01-01

Channel-forming activities in the glycosomal fraction from the bloodstream form of Trypanosoma brucei.

by Melisa Gualdron-López, Miia H Vapola, Ilkka J Miinalainen, J Kalervo Hiltunen, Paul A M Michels, Vasily D Antonenkov
Published 2012-01-01

Structures of pyruvate kinases display evolutionarily divergent allosteric strategies

by Hugh P. Morgan, Wenhe Zhong, Iain W. McNae, Paul A. M. Michels, Linda A. Fothergill-Gilmore, Malcolm D. Walkinshaw
Published 2014-01-01

Genetic and chemical evaluation of Trypanosoma brucei oleate desaturase as a candidate drug target.

by Andrés Alloatti, Shreedhara Gupta, Melisa Gualdrón-López, Mariana Igoillo-Esteve, Paul A Nguewa, Gladys Deumer, Pierre Wallemacq, Silvia G Altabe, Paul A M Michels, Antonio D Uttaro
Published 2010-12-01

Gamma-glutamylcysteine synthetase and tryparedoxin 1 exert high control on the antioxidant system in Trypanosoma cruzi contributing to drug resistance and infectivity

by Zabdi González-Chávez, Citlali Vázquez, Marlen Mejia-Tlachi, Claudia Márquez-Dueñas, Rebeca Manning-Cela, Rusely Encalada, Sara Rodríguez-Enríquez, Paul A.M. Michels, Rafael Moreno-Sánchez, Emma Saavedra
Published 2019-09-01

Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism.

by Simone Pieretti, Jurgen R Haanstra, Muriel Mazet, Remo Perozzo, Christian Bergamini, Federica Prati, Romana Fato, Giorgio Lenaz, Giovanni Capranico, Reto Brun, Barbara M Bakker, Paul A M Michels, Leonardo Scapozza, Maria Laura Bolognesi, Andrea Cavalli
Published 2013-01-01

Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice

by Iain W. McNae, James Kinkead, Divya Malik, Li-Hsuan Yen, Martin K. Walker, Chris Swain, Scott P. Webster, Nick Gray, Peter M. Fernandes, Elmarie Myburgh, Elizabeth A. Blackburn, Ryan Ritchie, Carol Austin, Martin A. Wear, Adrian J. Highton, Andrew J. Keats, Antonio Vong, Jacqueline Dornan, Jeremy C. Mottram, Paul A. M. Michels, Simon Pettit, Malcolm D. Walkinshaw
Published 2021-02-01

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery

by Pasquale Linciano, Alice Dawson, Ina Pöhner, David M. Costa, Monica S. Sá, Anabela Cordeiro-da-Silva, Rosaria Luciani, Sheraz Gul, Gesa Witt, Bernhard Ellinger, Maria Kuzikov, Philip Gribbon, Jeanette Reinshagen, Markus Wolf, Birte Behrens, Véronique Hannaert, Paul A. M. Michels, Erika Nerini, Cecilia Pozzi, Flavio di Pisa, Giacomo Landi, Nuno Santarem, Stefania Ferrari, Puneet Saxena, Sandra Lazzari, Giuseppe Cannazza, Lucio H. Freitas-Junior, Carolina B. Moraes, Bruno S. Pascoalino, Laura M. Alcântara, Claudia P. Bertolacini, Vanessa Fontana, Ulrike Wittig, Wolfgang Müller, Rebecca C. Wade, William N. Hunter, Stefano Mangani, Luca Costantino, Maria P. Costi
Published 2017-09-01