Oscillations, intercellular coupling, and insulin secretion in pancreatic beta cells.

by Patrick E MacDonald, Patrik Rorsman
Published 2006-02-01

DeSUMOylation Controls Insulin Exocytosis in Response to Metabolic Signals

by Patrick E. MacDonald, Xiaoqing Dai, Elisa Vergari, Gregory Plummer
Published 2012-05-01

Focused Review: Glucagon secretion and signaling in the development of diabetes

by Herbert eGaisano, Patrick E MacDonald, Mladen eVranic
Published 2012-09-01

A role for PKD1 in insulin secretion downstream of P2Y1 receptor activation in mouse and human islets

by Shara Khan, Mourad Ferdaoussi, Austin Bautista, Valérie Bergeron, Nancy Smith, Vincent Poitout, Patrick E. MacDonald
Published 2019-10-01

SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human ß cells

by Mourad Ferdaoussi, Jianyang Fu, Xiaoqing Dai, Jocelyn E. Manning Fox, Kunimasa Suzuki, Nancy Smith, Gregory Plummer, Patrick E. MacDonald
Published 2017-03-01

Human islets contain a subpopulation of glucagon-like peptide-1 secreting α cells that is increased in type 2 diabetes

by Scott A. Campbell, Dominic P. Golec, Matt Hubert, Janyne Johnson, Nicole Salamon, Amy Barr, Patrick E. MacDonald, Koenraad Philippaert, Peter E. Light
Published 2020-09-01

PI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets

by Jelena Kolic, Jocelyn E. Manning Fox, Oleg G. Chepurny, Aliya F. Spigelman, Mourad Ferdaoussi, Frank Schwede, George G. Holz, Patrick E. MacDonald
Published 2016-07-01

A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.

by Patrick E MacDonald, Yang Zhang De Marinis, Reshma Ramracheya, Albert Salehi, Xiaosong Ma, Paul R V Johnson, Roger Cox, Lena Eliasson, Patrik Rorsman
Published 2007-06-01

Improved glucose tolerance with DPPIV inhibition requires β‐cell SENP1 amplification of glucose‐stimulated insulin secretion

by Mourad Ferdaoussi, Nancy Smith, Haopeng Lin, Austin Bautista, Aliya F. Spigelman, James Lyon, XiaoQing Dai, Jocelyn E. Manning Fox, Patrick E. MacDonald
Published 2020-04-01

Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism

by Jessica R. Gooding, Mette V. Jensen, Xiaoqing Dai, Brett R. Wenner, Danhong Lu, Ramamani Arumugam, Mourad Ferdaoussi, Patrick E. MacDonald, Christopher B. Newgard
Published 2015-10-01

Transplantation of Human Pancreatic Endoderm Cells Reverses Diabetes Post Transplantation in a Prevascularized Subcutaneous Site

by Andrew R. Pepper, Rena Pawlick, Antonio Bruni, John Wink, Yasmin Rafiei, Doug O’Gorman, Richard Yan-Do, Boris Gala-Lopez, Tatsuya Kin, Patrick E. MacDonald, A.M. James Shapiro
Published 2017-06-01

Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors.

by Martijn van de Bunt, Jocelyn E Manning Fox, Xiaoqing Dai, Amy Barrett, Caleb Grey, Lei Li, Amanda J Bennett, Paul R Johnson, Raymond V Rajotte, Kyle J Gaulton, Emmanouil T Dermitzakis, Patrick E MacDonald, Mark I McCarthy, Anna L Gloyn
Published 2015-12-01

CRISPR-based genome editing in primary human pancreatic islet cells

by Romina J. Bevacqua, Xiaoqing Dai, Jonathan Y. Lam, Xueying Gu, Mollie S. H. Friedlander, Krissie Tellez, Irene Miguel-Escalada, Silvia Bonàs-Guarch, Goutham Atla, Weichen Zhao, Seung Hyun Kim, Antonia A. Dominguez, Lei S. Qi, Jorge Ferrer, Patrick E. MacDonald, Seung K. Kim
Published 2021-04-01

Improvement of islet transplantation by the fusion of islet cells with functional blood vessels

by Lisa Nalbach, Leticia P Roma, Beate M Schmitt, Vivien Becker, Christina Körbel, Selina Wrublewsky, Mandy Pack, Thomas Später, Wolfgang Metzger, Maximilian M Menger, Florian S Frueh, Claudia Götz, Haopeng Lin, Jocelyn E Manning Fox, Patrick E MacDonald, Michael D Menger, Matthias W Laschke, Emmanuel Ampofo
Published 2021-01-01

Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion

by Katrina Viloria, Daniela Nasteska, Linford J.B. Briant, Silke Heising, Dean P. Larner, Nicholas H.F. Fine, Fiona B. Ashford, Gabriela da Silva Xavier, Maria Jiménez Ramos, Annie Hasib, Federica Cuozzo, Jocelyn E. Manning Fox, Patrick E. MacDonald, Ildem Akerman, Gareth G. Lavery, Christine Flaxman, Noel G. Morgan, Sarah J. Richardson, Martin Hewison, David J. Hodson
Published 2020-06-01

Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D

by Ana Viñuela, Arushi Varshney, Martijn van de Bunt, Rashmi B. Prasad, Olof Asplund, Amanda Bennett, Michael Boehnke, Andrew A. Brown, Michael R. Erdos, João Fadista, Ola Hansson, Gad Hatem, Cédric Howald, Apoorva K. Iyengar, Paul Johnson, Ulrika Krus, Patrick E. MacDonald, Anubha Mahajan, Jocelyn E. Manning Fox, Narisu Narisu, Vibe Nylander, Peter Orchard, Nikolay Oskolkov, Nikolaos I. Panousis, Anthony Payne, Michael L. Stitzel, Swarooparani Vadlamudi, Ryan Welch, Francis S. Collins, Karen L. Mohlke, Anna L. Gloyn, Laura J. Scott, Emmanouil T. Dermitzakis, Leif Groop, Stephen C. J. Parker, Mark I. McCarthy
Published 2020-09-01