SPOTing Acetyl-Lysine Dependent Interactions

by Sarah Picaud, Panagis Filippakopoulos
Published 2015-08-01

Editorial: Structural Studies of Protein Complexes in Signaling Pathways

by Filippo Prischi, Panagis Filippakopoulos
Published 2021-04-01

BETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophy

by Marco Segatto, Roberta Szokoll, Raffaella Fittipaldi, Cinzia Bottino, Lorenzo Nevi, Kamel Mamchaoui, Panagis Filippakopoulos, Giuseppina Caretti
Published 2020-11-01

Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12

by Zhuoyao Chen, Gregory A. Wasney, Sarah Picaud, Panagis Filippakopoulos, Masoud Vedadi, Vincenzo D'Angiolella, Alex N. Bullock
Published 2020-06-01

Crystal Structure and Inhibitor Identifications Reveal Targeting Opportunity for the Atypical MAPK Kinase ERK3

by Martin Schröder, Panagis Filippakopoulos, Martin P. Schwalm, Carla A. Ferrer, David H. Drewry, Stefan Knapp, Apirat Chaikuad
Published 2020-10-01

Dissecting the Role of BET Bromodomain Proteins BRD2 and BRD4 in Human NK Cell Function

by Adam P. Cribbs, Panagis Filippakopoulos, Martin Philpott, Graham Wells, Henry Penn, Henrik Oerum, Viia Valge-Archer, Marc Feldmann, Udo Oppermann, Udo Oppermann, Udo Oppermann
Published 2021-02-01

A TFEB nuclear export signal integrates amino acid supply and glucose availability

by Linxin Li, Hans J. Friedrichsen, Sarah Andrews, Sarah Picaud, Laurent Volpon, Kaochin Ngeow, Georgina Berridge, Roman Fischer, Katherine L. B. Borden, Panagis Filippakopoulos, Colin R. Goding
Published 2018-07-01

A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex

by Chiara Marabelli, Biagina Marrocco, Simona Pilotto, Sagar Chittori, Sarah Picaud, Sara Marchese, Giuseppe Ciossani, Federico Forneris, Panagis Filippakopoulos, Guy Schoehn, Daniela Rhodes, Sriram Subramaniam, Andrea Mattevi
Published 2019-04-01

BET inhibition disrupts transcription but retains enhancer-promoter contact

by Nicholas T. Crump, Erica Ballabio, Laura Godfrey, Ross Thorne, Emmanouela Repapi, Jon Kerry, Marta Tapia, Peng Hua, Christoffer Lagerholm, Panagis Filippakopoulos, James O. J. Davies, Thomas A. Milne
Published 2021-01-01

Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival

by Marco Segatto, Raffaella Fittipaldi, Fabrizio Pin, Roberta Sartori, Kyung Dae Ko, Hossein Zare, Claudio Fenizia, Gianpietro Zanchettin, Elisa Sefora Pierobon, Shinji Hatakeyama, Cosimo Sperti, Stefano Merigliano, Marco Sandri, Panagis Filippakopoulos, Paola Costelli, Vittorio Sartorelli, Giuseppina Caretti
Published 2017-11-01

A chemical toolbox for the study of bromodomains and epigenetic signaling

by Qin Wu, David Heidenreich, Stanley Zhou, Suzanne Ackloo, Andreas Krämer, Kiran Nakka, Evelyne Lima-Fernandes, Genevieve Deblois, Shili Duan, Ravi N. Vellanki, Fengling Li, Masoud Vedadi, Jeffrey Dilworth, Mathieu Lupien, Paul E. Brennan, Cheryl H. Arrowsmith, Susanne Müller, Oleg Fedorov, Panagis Filippakopoulos, Stefan Knapp
Published 2019-04-01

Nut Directs p300-Dependent, Genome-Wide H4 Hyperacetylation in Male Germ Cells

by Hitoshi Shiota, Sophie Barral, Thierry Buchou, Minjia Tan, Yohann Couté, Guillaume Charbonnier, Nicolas Reynoird, Fayçal Boussouar, Matthieu Gérard, Mingrui Zhu, Lisa Bargier, Denis Puthier, Florent Chuffart, Ekaterina Bourova-Flin, Sarah Picaud, Panagis Filippakopoulos, Afsaneh Goudarzi, Ziad Ibrahim, Daniel Panne, Sophie Rousseaux, Yingming Zhao, Saadi Khochbin
Published 2018-09-01