Mitigation of liquid-liquid phase separation of a monoclonal antibody by mutations of negative charges on the Fab surface.

by Tatsuji Matsuoka, Ryuki Miyauchi, Nobumi Nagaoka, Jun Hasegawa
Published 2020-01-01

Anti‐ORAI1 antibody DS‐2741a, a specific CRAC channel blocker, shows ideal therapeutic profiles for allergic disease via suppression of aberrant T‐cell and mast cell activation...

by Anri Aki, Kento Tanaka, Nobumi Nagaoka, Takako Kimura, Daichi Baba, Yoshikuni Onodera, Teiji Wada, Hiroaki Maeda, Toshiyuki Nakanishi, Toshinori Agatsuma, Tomoaki Komai
Published 2020-08-01