Normal aging modulates the neurotoxicity of mutant huntingtin.

by Elsa Diguet, Fanny Petit, Carole Escartin, Karine Cambon, Nicolas Bizat, Noëlle Dufour, Philippe Hantraye, Nicole Déglon, Emmanuel Brouillet
Published 2009-01-01

Allele-specific RNA silencing of mutant ataxin-3 mediates neuroprotection in a rat model of Machado-Joseph disease.

by Sandro Alves, Isabel Nascimento-Ferreira, Gwennaëlle Auregan, Raymonde Hassig, Noëlle Dufour, Emmanuel Brouillet, Maria C Pedroso de Lima, Philippe Hantraye, Luís Pereira de Almeida, Nicole Déglon
Published 2008-10-01

Preclinical Evaluation of a Lentiviral Vector for Huntingtin Silencing

by Karine Cambon, Virginie Zimmer, Sylvain Martineau, Marie-Claude Gaillard, Margot Jarrige, Aurore Bugi, Jana Miniarikova, Maria Rey, Raymonde Hassig, Noelle Dufour, Gwenaelle Auregan, Philippe Hantraye, Anselme L. Perrier, Nicole Déglon
Published 2017-06-01

Allele-specific silencing of mutant huntingtin in rodent brain and human stem cells.

by Valérie Drouet, Marta Ruiz, Diana Zala, Maxime Feyeux, Gwennaëlle Auregan, Karine Cambon, Laetitia Troquier, Johann Carpentier, Sophie Aubert, Nicolas Merienne, Fany Bourgois-Rocha, Raymonde Hassig, Maria Rey, Noëlle Dufour, Frédéric Saudou, Anselme L Perrier, Philippe Hantraye, Nicole Déglon
Published 2014-01-01

Comparison Between Several Integrase-defective Lentiviral Vectors Reveals Increased Integration of an HIV Vector Bearing a D167H Mutant

by Muhammad Qamar Saeed, Noelle Dufour, Cynthia Bartholmae, Urzula Sieranska, Malaika Knopf, Eloïse Thierry, Sylvain Thierry, Olivier Delelis, Nicolas Grandchamp, Héloïse Pilet, Philippe Ravassard, Julie Massonneau, Françoise Pflumio, Christof von Kalle, François Lachapelle, Alexis-Pierre Bemelmans, Manfred Schmidt, Ché Serguera
Published 2014-01-01

The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo

by Noémie Cresto, Marie-Claude Gaillard, Camille Gardier, Francesco Gubinelli, Elsa Diguet, Déborah Bellet, Laurine Legroux, Julien Mitja, Gwenaëlle Auregan, Martine Guillermier, Charlène Josephine, Caroline Jan, Noëlle Dufour, Alain Joliot, Philippe Hantraye, Gilles Bonvento, Nicole Déglon, Alexis-Pierre Bemelmans, Karine Cambon, Géraldine Liot, Emmanuel Brouillet
Published 2020-02-01

The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo

by Noémie Cresto, Camille Gardier, Marie-Claude Gaillard, Francesco Gubinelli, Pauline Roost, Daniela Molina, Charlène Josephine, Noëlle Dufour, Gwenaëlle Auregan, Martine Guillermier, Suéva Bernier, Caroline Jan, Pauline Gipchtein, Philippe Hantraye, Marie-Christine Chartier-Harlin, Gilles Bonvento, Nadja Van Camp, Jean-Marc Taymans, Karine Cambon, Géraldine Liot, Alexis-Pierre Bemelmans, Emmanuel Brouillet
Published 2021-06-01