Pathways in pulmonary arterial hypertension: the future is here

by Olivier Sitbon, Nicholas W. Morrell
Published 2012-12-01

A sex-specific reconstitution bias in the competitive CD45.1/CD45.2 congenic bone marrow transplant model

by Salema Jafri, Stephen D. Moore, Nicholas W. Morrell, Mark L. Ormiston
Published 2017-06-01

Disrupted Endothelial Cell Layer and Exposed Extracellular Matrix Proteins Promote Capture of Late Outgrowth Endothelial Progenitor Cells

by Jing Zhao, Claudia-Gabriela Mitrofan, Sarah L. Appleby, Nicholas W. Morrell, Andrew M. L. Lever
Published 2016-01-01

‘There and Back Again’—Forward Genetics and Reverse Phenotyping in Pulmonary Arterial Hypertension

by Emilia M. Swietlik, Matina Prapa, Jennifer M. Martin, Divya Pandya, Kathryn Auckland, Nicholas W. Morrell, Stefan Gräf
Published 2020-11-01

Targeting translational read-through of premature termination mutations in with PTC124 for pulmonary arterial hypertension

by Lu Long, Xudong Yang, Mark Southwood, Stephen Moore, Alexi Crosby, Paul D. Upton, Benjamin J. Dunmore, Nicholas W. Morrell
Published 2020-07-01

Reduced circulating BMP10 and BMP9 and elevated endoglin are associated with disease severity, decompensation and pulmonary vascular syndromes in patients with cirrhosis

by Nicola E. Owen, Graeme J. Alexander, Sambit Sen, Katherine Bunclark, Gary Polwarth, Joanna Pepke-Zaba, Anthony P. Davenport, Nicholas, W. Morrell, Paul. D. Upton
Published 2020-06-01

Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms

by Richard M. Salmon, Jingxu Guo, Jennifer H. Wood, Zhen Tong, John S. Beech, Aleksandra Lawera, Minmin Yu, David J. Grainger, Jill Reckless, Nicholas W. Morrell, Wei Li
Published 2020-04-01

BMP-9 induced endothelial cell tubule formation and inhibition of migration involves Smad1 driven endothelin-1 production.

by John E S Park, Dongmin Shao, Paul D Upton, Patricia Desouza, Ian M Adcock, Rachel J Davies, Nicholas W Morrell, Mark J D Griffiths, Stephen J Wort
Published 2012-01-01

Correction: BMP-9 Induced Endothelial Cell Tubule Formation and Inhibition of Migration Involves Smad1 Driven Endothelin-1 Production

by John E. S. Park, Dongmin Shao, Paul D. Upton, Patricia deSouza, Ian M. Adcock, Rachel J. Davies, Nicholas W. Morrell, Mark J. D. Griffiths, Stephen J. Wort
Published 2013-01-01

Correction: BMP-9 Induced Endothelial Cell Tubule Formation and Inhibition of Migration Involves Smad1 Driven Endothelin-1 Production.

by John E. S. Park, Dongmin Shao, Paul D. Upton, Patricia deSouza, Ian M. Adcock, Rachel J. Davies, Nicholas W. Morrell, Mark J. D. Griffiths, Stephen J. Wort
Published 2013-01-01

Differential IL-1 signaling induced by BMPR2 deficiency drives pulmonary vascular remodeling

by Josephine Pickworth, Alexander Rothman, James Iremonger, Helen Casbolt, Kay Hopkinson, Peter M. Hickey, Santhi Gladson, Sheila Shay, Nicholas W. Morrell, Sheila E. Francis, James D. West, Allan Lawrie
Published 2017-09-01

Hematopoietic stem cell transplantation alters susceptibility to pulmonary hypertension in -deficient mice

by Alexi Crosby, Mark R. Toshner, Mark R. Southwood, Elaine Soon, Benjamin J. Dunmore, Emily Groves, Stephen Moore, Penny Wright, Katrin Ottersbach, Cavan Bennett, Jose Guerrero, Cedric Ghevaert, Nicholas W. Morrell
Published 2018-09-01

Transcript analysis reveals a specific HOX signature associated with positional identity of human endothelial cells.

by Mark Toshner, Benjamin J Dunmore, Eoin F McKinney, Mark Southwood, Paola Caruso, Paul D Upton, John P Waters, Mark L Ormiston, Jeremy N Skepper, Gerard Nash, Amer A Rana, Nicholas W Morrell
Published 2014-01-01

Bone Morphogenetic Protein 9 Protects against Neonatal Hyperoxia-Induced Impairment of Alveolarization and Pulmonary Inflammation

by Xueyu Chen, Mar Orriols, Frans J. Walther, Frans J. Walther, El Houari Laghmani, Annemarie M. Hoogeboom, Anne C. B. Hogen-Esch, Pieter S. Hiemstra, Gert Folkerts, Marie-José T. H. Goumans, Peter ten Dijke, Nicholas W. Morrell, Gerry T. M. Wagenaar
Published 2017-07-01

TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling

by Liam A. Hurst, Benjamin J. Dunmore, Lu Long, Alexi Crosby, Rafia Al-Lamki, John Deighton, Mark Southwood, Xudong Yang, Marko Z. Nikolic, Blanca Herrera, Gareth J. Inman, John R. Bradley, Amer A. Rana, Paul D. Upton, Nicholas W. Morrell
Published 2017-01-01

Expression Quantitative Trait Locus Mapping in Pulmonary Arterial Hypertension

by Anna Ulrich, Pablo Otero-Núñez, John Wharton, Emilia M. Swietlik, Stefan Gräf, Nicholas W. Morrell, Dennis Wang, Allan Lawrie, Martin R. Wilkins, Inga Prokopenko, Christopher J. Rhodes, on behalf of The NIHR BioResource—Rare Diseases Consortium, UK PAH Cohort Study Consortium
Published 2020-10-01

A diagnostic miRNA signature for pulmonary arterial hypertension using a consensus machine learning approach

by Niamh Errington, James Iremonger, Josephine A. Pickworth, Sokratis Kariotis, Christopher J. Rhodes, Alexander MK Rothman, Robin Condliffe, Charles A. Elliot, David G. Kiely, Luke S. Howard, John Wharton, A. A. Roger Thompson, Nicholas W Morrell, Martin R. Wilkins, Dennis Wang, Allan Lawrie
Published 2021-07-01

Central Role of Dendritic Cells in Pulmonary Arterial Hypertension in Human and Mice

by Denise van Uden, Thomas Koudstaal, Jennifer A. C. van Hulst, Ingrid M. Bergen, Chelsea Gootjes, Nicholas W. Morrell, Geert van Loo, Jan H. von der Thüsen, Thierry P. P. van den Bosch, Maria-Rosa Ghigna, Frédéric Perros, David Montani, Mirjam Kool, Karin A. Boomars, Rudi W. Hendriks
Published 2021-02-01

An iPSC-Derived Myeloid Lineage Model of Herpes Virus Latency and Reactivation

by Emma Poole, Christopher J. Z. Huang, Jessica Forbester, Miri Shnayder, Aharon Nachshon, Baraa Kweider, Anna Basaj, Daniel Smith, Sarah Elizabeth Jackson, Bin Liu, Joy Shih, Fedir N. Kiskin, K. Roche, E. Murphy, Mark R. Wills, Nicholas W. Morrell, Gordon Dougan, Gordon Dougan, Noam Stern-Ginossar, Amer A. Rana, John Sinclair
Published 2019-10-01

Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2

by Tatyana Novoyatleva, Nabham Rai, Baktybek Kojonazarov, Swathi Veeroju, Isabel Ben-Batalla, Paola Caruso, Mazen Shihan, Nadine Presser, Elsa Götz, Carina Lepper, Sebastian Herpel, Grégoire Manaud, Frédéric Perros, Henning Gall, Hossein Ardeschir Ghofrani, Norbert Weissmann, Friedrich Grimminger, John Wharton, Martin Wilkins, Paul D. Upton, Sonja Loges, Nicholas W. Morrell, Werner Seeger, Ralph T. Schermuly
Published 2021-08-01