Inhibition of polo-like kinase 1 (PLK1) facilitates reactivation of gamma-herpesviruses and their elimination.

by Ayan Biswas, Dawei Zhou, Guillaume N Fiches, Zhenyu Wu, Xuefeng Liu, Qin Ma, Weiqiang Zhao, Jian Zhu, Netty G Santoso
Published 2021-07-01

Inhibition of Tip60 Reduces Lytic and Latent Gene Expression of Kaposi’s Sarcoma-Associated Herpes Virus (KSHV) and Proliferation of KSHV-Infected Tumor Cells

by Sydney Simpson, Guillaume Fiches, Maxime J. Jean, Michael Dieringer, James McGuinness, Sinu P. John, Meir Shamay, Prashant Desai, Jian Zhu, Netty G. Santoso
Published 2018-04-01

Curaxin CBL0100 Blocks HIV-1 Replication and Reactivation through Inhibition of Viral Transcriptional Elongation

by Maxime J. Jean, Tsuyoshi Hayashi, Huachao Huang, Justin Brennan, Sydney Simpson, Andrei Purmal, Katerina Gurova, Michael C. Keefer, James J. Kobie, Netty G. Santoso, Jian Zhu, Jian Zhu
Published 2017-10-01

A Novel Bromodomain Inhibitor Reverses HIV-1 Latency through Specific Binding with BRD4 to Promote Tat and P-TEFb Association

by Huachao Huang, Shuai Liu, Maxime Jean, Sydney Simpson, He Huang, Mark Merkley, Tsuyoshi Hayashi, Weili Kong, Irene Rodríguez-Sánchez, Xiaofeng Zhang, Hailemichael O. Yosief, Hongyu Miao, Jianwen Que, James J. Kobie, James Bradner, Netty G. Santoso, Wei Zhang, Jian Zhu
Published 2017-06-01