Mutant-selective degradation by BRAF-targeting PROTACs

by Shanique Alabi, Saul Jaime-Figueroa, Zhan Yao, Yijun Gao, John Hines, Kusal T. G. Samarasinghe, Lea Vogt, Neal Rosen, Craig M. Crews
Published 2021-02-01

Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling.

by Qing-Bai She, Sarat Chandarlapaty, Qing Ye, Jose Lobo, Kathleen M Haskell, Karen R Leander, Deborah DeFeo-Jones, Hans E Huber, Neal Rosen
Published 2008-08-01

Monitoring the Induction of Heat Shock Factor 1/Heat Shock Protein 70 Expression following 17-Allylamino-Demethoxygeldanamycin Treatment by Positron Emission Tomography and Optical...

by Mikhail Doubrovin, Jian T. Che, Inna Serganova, Ekaterina Moroz, David B. Solit, Lyudmila Ageyeva, Tatiana Kochetkova, Nagavarakishore Pillarsetti, Ronald Finn, Neal Rosen, Ronald G. Blasberg
Published 2012-01-01

Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors.

by Lucia Regales, Marissa N Balak, Yixuan Gong, Katerina Politi, Ayana Sawai, Carl Le, Jason A Koutcher, David B Solit, Neal Rosen, Maureen F Zakowski, William Pao
Published 2007-08-01

Defining the therapeutic selective dependencies for distinct subtypes of PI3K pathway-altered prostate cancers

by Ninghui Mao, Zeda Zhang, Young Sun Lee, Danielle Choi, Aura Agudelo Rivera, Dan Li, Cindy Lee, Samuel Haywood, Xiaoping Chen, Qing Chang, Guotai Xu, Hsuan-An Chen, Elisa de Stanchina, Charles Sawyers, Neal Rosen, Andrew C. Hsieh, Yu Chen, Brett S. Carver
Published 2021-08-01

RAF dimer inhibition enhances the antitumor activity of MEK inhibitors in K‐RAS mutant tumors

by Xi Yuan, Zhiyu Tang, Rong Du, Zhan Yao, Shing‐Hu Cheung, Xinwen Zhang, Jing Wei, Yuan Zhao, Yunguang Du, Ye Liu, Xiaoxia Hu, Wenfeng Gong, Yong Liu, Yajuan Gao, Zhiyue Huang, Zongfu Cao, Min Wei, Changyou Zhou, Lai Wang, Neal Rosen, Paul D. Smith, Lusong Luo
Published 2020-08-01

Anti-tumor effects of an ID antagonist with no observed acquired resistance

by Paulina M. Wojnarowicz, Marta Garcia Escolano, Yun-Han Huang, Bina Desai, Yvette Chin, Riddhi Shah, Sijia Xu, Saurabh Yadav, Sergey Yaklichkin, Ouathek Ouerfelli, Rajesh Kumar Soni, John Philip, David C. Montrose, John H. Healey, Vinagolu K. Rajasekhar, William A. Garland, Jeremy Ratiu, Yuan Zhuang, Larry Norton, Neal Rosen, Ronald C. Hendrickson, Xi Kathy Zhou, Antonio Iavarone, Joan Massague, Andrew J. Dannenberg, Anna Lasorella, Robert Benezra
Published 2021-05-01