Escape Mutations, Ganciclovir Resistance, and Teratoma Formation in Human iPSCs Expressing an HSVtk Suicide Gene

by Andriana G Kotini, Elisa de Stanchina, Maria Themeli, Michel Sadelain, Eirini P Papapetrou
Published 2016-01-01

Establishing and Maintaining an Extensive Library of Patient-Derived Xenograft Models

by Marissa Mattar, Craig R. McCarthy, Amanda R. Kulick, Besnik Qeriqi, Sean Guzman, Elisa de Stanchina
Published 2018-02-01

Impact of combined mTOR and MEK inhibition in uveal melanoma is driven by tumor genotype.

by Alan L Ho, Elgilda Musi, Grazia Ambrosini, Jayasree S Nair, Shyamprasad Deraje Vasudeva, Elisa de Stanchina, Gary K Schwartz
Published 2012-01-01

Anti gC1qR/p32/HABP1 Antibody Therapy Decreases Tumor Growth in an Orthotopic Murine Xenotransplant Model of Triple Negative Breast Cancer

by Ellinor I. Peerschke, Elisa de Stanchina, Qing Chang, Katia Manova-Todorova, Afsar Barlas, Anne G. Savitt, Brian V. Geisbrecht, Berhane Ghebrehiwet
Published 2020-10-01

Overcoming resistance to HER2-targeted therapy with a novel HER2/CD3 bispecific antibody

by Andres Lopez-Albaitero, Hong Xu, Hongfen Guo, Linlin Wang, Zhihao Wu, Hoa Tran, Sarat Chandarlapaty, Maurizio Scaltriti, Yelena Janjigian, Elisa de Stanchina, Nai-Kong V. Cheung
Published 2017-03-01

NRF2 Activation Confers Resistance to eIF4A Inhibitors in Cancer Therapy

by Viraj R. Sanghvi, Prathibha Mohan, Kamini Singh, Linlin Cao, Marjan Berishaj, Andrew L. Wolfe, Jonathan H. Schatz, Nathalie Lailler, Elisa de Stanchina, Agnes Viale, Hans-Guido Wendel
Published 2021-02-01

gC1qR/HABP1/p32 Is a Potential New Therapeutic Target Against Mesothelioma

by Ellinor Peerschke, Kenneth Stier, Xiaoyu Li, Xiaoyu Li, Evelyn Kandov, Elisa de Stanchina, Qing Chang, Yuquan Xiong, Katia Manova-Todorova, Ning Fan, Afsar Barlas, Berhane Ghebrehiwet, Prasad S. Adusumilli
Published 2020-08-01

Peptidomimetic blockade of MYB in acute myeloid leukemia

by Kavitha Ramaswamy, Lauren Forbes, Gerard Minuesa, Tatyana Gindin, Fiona Brown, Michael G. Kharas, Andrei V. Krivtsov, Scott A. Armstrong, Eric Still, Elisa de Stanchina, Birgit Knoechel, Richard Koche, Alex Kentsis
Published 2018-01-01

PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis

by Norihiro Yamaguchi, Ethan M Weinberg, Alexander Nguyen, Maria V Liberti, Hani Goodarzi, Yelena Y Janjigian, Philip B Paty, Leonard B Saltz, T Peter Kingham, Jia Min Loo, Elisa de Stanchina, Sohail F Tavazoie
Published 2019-12-01

CryoPause: A New Method to Immediately Initiate Experiments after Cryopreservation of Pluripotent Stem Cells

by Karen G. Wong, Sean D. Ryan, Kiran Ramnarine, Siera A. Rosen, Shannon E. Mann, Amanda Kulick, Elisa De Stanchina, Franz-Josef Müller, Thadeous J. Kacmarczyk, Chao Zhang, Doron Betel, Mark J. Tomishima
Published 2017-07-01

NTRK kinase domain mutations in cancer variably impact sensitivity to type I and type II inhibitors

by Romel Somwar, Nicolle E. Hofmann, Bryan Smith, Igor Odintsov, Morana Vojnic, Irina Linkov, Ashley Tam, Inna Khodos, Marissa S. Mattar, Elisa de Stanchina, Daniel Flynn, Marc Ladanyi, Alexander Drilon, Ujwal Shinde, Monika A. Davare
Published 2020-12-01

Nontranscriptional Role of Hif-1α in Activation of γ-Secretase and Notch Signaling in Breast Cancer

by Jennifer C. Villa, Danica Chiu, Alissa H. Brandes, Freddy E. Escorcia, Carlos H. Villa, William F. Maguire, Cheng-Jun Hu, Elisa de Stanchina, M. Celeste Simon, Sangram S. Sisodia, David A. Scheinberg, Yue-Ming Li
Published 2014-08-01

Defining the therapeutic selective dependencies for distinct subtypes of PI3K pathway-altered prostate cancers

by Ninghui Mao, Zeda Zhang, Young Sun Lee, Danielle Choi, Aura Agudelo Rivera, Dan Li, Cindy Lee, Samuel Haywood, Xiaoping Chen, Qing Chang, Guotai Xu, Hsuan-An Chen, Elisa de Stanchina, Charles Sawyers, Neal Rosen, Andrew C. Hsieh, Yu Chen, Brett S. Carver
Published 2021-08-01

Acquired Resistance of EGFR-Mutant Lung Adenocarcinomas to Afatinib plus Cetuximab Is Associated with Activation of mTORC1

by Valentina Pirazzoli, Caroline Nebhan, Xiaoling Song, Anna Wurtz, Zenta Walther, Guoping Cai, Zhongming Zhao, Peilin Jia, Elisa de Stanchina, Erik M. Shapiro, Molly Gale, Ruonan Yin, Leora Horn, David P. Carbone, Philip J. Stephens, Vincent Miller, Scott Gettinger, William Pao, Katerina Politi
Published 2014-05-01

Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer

by Corrin A. Wohlhieter, Allison L. Richards, Fathema Uddin, Christopher H. Hulton, Àlvaro Quintanal-Villalonga, Axel Martin, Elisa de Stanchina, Umeshkumar Bhanot, Marina Asher, Nisargbhai S. Shah, Omar Hayatt, Darren J. Buonocore, Natasha Rekhtman, Ronglai Shen, Kathryn C. Arbour, Mark Donoghue, John T. Poirier, Triparna Sen, Charles M. Rudin
Published 2020-12-01

A Novel JAK1 Mutant Breast Implant-Associated Anaplastic Large Cell Lymphoma Patient-Derived Xenograft Fostering Pre-Clinical Discoveries

by Danilo Fiore, Luca Vincenzo Cappelli, Paul Zumbo, Jude M. Phillips, Zhaoqi Liu, Shuhua Cheng, Liron Yoffe, Paola Ghione, Federica Di Maggio, Ahmet Dogan, Inna Khodos, Elisa de Stanchina, Joseph Casano, Clarisse Kayembe, Wayne Tam, Doron Betel, Robin Foa’, Leandro Cerchietti, Raul Rabadan, Steven Horwitz, David M. Weinstock, Giorgio Inghirami
Published 2020-06-01

RET inhibition in novel patient-derived models of RET fusion- positive lung adenocarcinoma reveals a role for MYC upregulation

by Takuo Hayashi, Igor Odintsov, Roger S. Smith, Kota Ishizawa, Allan J. W. Liu, Lukas Delasos, Christopher Kurzatkowski, Huichun Tai, Eric Gladstone, Morana Vojnic, Shinji Kohsaka, Ken Suzawa, Zebing Liu, Siddharth Kunte, Marissa S. Mattar, Inna Khodos, Monika A. Davare, Alexander Drilon, Emily Cheng, Elisa de Stanchina, Marc Ladanyi, Romel Somwar
Published 2021-02-01

The IL-6/JAK/Stat3 Feed-Forward Loop Drives Tumorigenesis and Metastasis

by Qing Chang, Eirini Bournazou, Pasquale Sansone, Marjan Berishaj, Sizhi Paul Gao, Laura Daly, Jared Wels, Till Theilen, Selena Granitto, Xinmin Zhang, Jesse Cotari, Mary L. Alpaugh, Elisa de Stanchina, Katia Manova, Ming Li, Massimiliano Bonafe, Claudio Ceccarelli, Mario Taffurelli, Donatella Santini, Gregoire Altan-Bonnet, Rosandra Kaplan, Larry Norton, Norihiro Nishimoto, Dennis Huszar, David Lyden, Jacqueline Bromberg
Published 2013-07-01

Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone

by Pengrong Yan, Hardik J. Patel, Sahil Sharma, Adriana Corben, Tai Wang, Palak Panchal, Chenghua Yang, Weilin Sun, Thais L. Araujo, Anna Rodina, Suhasini Joshi, Kenneth Robzyk, Srinivasa Gandu, Julie R. White, Elisa de Stanchina, Shanu Modi, Yelena Y. Janjigian, Elizabeth G. Hill, Bei Liu, Hediye Erdjument-Bromage, Thomas A. Neubert, Nanette L.S. Que, Zihai Li, Daniel T. Gewirth, Tony Taldone, Gabriela Chiosis
Published 2020-06-01

524 Tim-4+ resident macrophages impair anti-tumor immunity in the serous body cavities By sequestering viable and cytotoxic CD8+ T cells expressing high levels of phosphatidylserin...

by Michael Green, Dmitriy Zamarin, Katherine Panageas, Taha Merghoub, Weiping Zou, Cailian Liu, Jedd Wolchok, Matthew Hellmann, Joseph Chan, Hongyu Shi, Hira Rizvi, Jessica Waninger, Aditi Gupta, Nicholas Ceglia, Viola Allaj, Giulia Zago, Nisarg Shah, Sai Sharma, Marissa Mattar, Yonina Bykov, Corrin Wohlhieter, Fathema Uddin, Inna Khodos, Angel Qin, Vinod Balachandran, Sohrab Shah, Andrew McPherson, Jason Lewis, Justin Perry, Elisa de Stanchina, Triparna Sen, John Poirier, Charles Rudin
Published 2020-11-01