Combination of TRAIL with bortezomib shifted apoptotic signaling from DR4 to DR5 death receptor by selective internalization and degradation of DR4.

by Maxim L Bychkov, Marine E Gasparian, Dmitry A Dolgikh, Mikhail P Kirpichnikov
Published 2014-01-01

Death Receptors DR4 and DR5 Undergo Spontaneous and Ligand-Mediated Endocytosis and Recycling Regardless of the Sensitivity of Cancer Cells to TRAIL

by Artem A. Artykov, Anne V. Yagolovich, Anne V. Yagolovich, Dmitry A. Dolgikh, Dmitry A. Dolgikh, Mikhail P. Kirpichnikov, Mikhail P. Kirpichnikov, Daria B. Trushina, Marine E. Gasparian
Published 2021-09-01

Abstract P-19: 15-Microsecond Molecular Dynamics Simulations of Nucleosome Show Structural Heterogeneity and Plasticity

by Grigoriy A. Armeev, Anastasiia S. Kniazeva, Galina A. Komarova, Mikhail P. Kirpichnikov, Alexey K. Shaytan
Published 2021-06-01

Histone dynamics mediate DNA unwrapping and sliding in nucleosomes

by Grigoriy A. Armeev, Anastasiia S. Kniazeva, Galina A. Komarova, Mikhail P. Kirpichnikov, Alexey K. Shaytan
Published 2021-04-01

Abstract P-1: Analysis of Tick-borne Encephalitis Virus Single-particle Imaging on X-ray Free-electron Laser

by Grigoriy A. Armeev, Alexey K. Shaytan, Mikhail F. Vorovich, Alexey M. Egorov, Aydar A. Ishmukhametov, Mikhail P. Kirpichnikov, Konstantin V. Shaitan
Published 2021-06-01

SLURP-1 Controls Growth and Migration of Lung Adenocarcinoma Cells, Forming a Complex With α7-nAChR and PDGFR/EGFR Heterodimer

by Maxim L. Bychkov, Mikhail A. Shulepko, Olga V. Shlepova, Olga V. Shlepova, Dmitrii S. Kulbatskii, Irina A. Chulina, Alexander S. Paramonov, Ludmila K. Baidakova, Viatcheslav N. Azev, Sergey G. Koshelev, Mikhail P. Kirpichnikov, Mikhail P. Kirpichnikov, Zakhar O. Shenkarev, Zakhar O. Shenkarev, Ekaterina N. Lyukmanova, Ekaterina N. Lyukmanova, Ekaterina N. Lyukmanova
Published 2021-09-01

Abstract OR-3: Integrative Structural Study of the Complex of Snake Toxin WTX with α7-type Nicotinic Acetylcholine Receptor

by Ekaterina N. Lyukmanova, Maxim M. Zaigraev, Dmitrii S. Kulbatskii, Milita V. Kocharovskaya, Yury M. Chesnokov, Anton O. Chugunov, Mikhail P. Kirpichnikov, Zakhar O. Shenkarev
Published 2021-06-01

Structural Diversity and Dynamics of Human Three-Finger Proteins Acting on Nicotinic Acetylcholine Receptors

by Alexander S. Paramonov, Milita V. Kocharovskaya, Andrey V. Tsarev, Dmitrii S. Kulbatskii, Eugene V. Loktyushov, Mikhail A. Shulepko, Mikhail P. Kirpichnikov, Ekaterina N. Lyukmanova, Zakhar O. Shenkarev
Published 2020-10-01

Chemotherapeutic Agents Sensitize Resistant Cancer Cells to the DR5-Specific Variant DR5-B more Efficiently than to TRAIL by Modulating the Surface Expression of Death and Decoy Re...

by Аrtem А. Аrtykov, Dmitry A. Belov, Victoria O. Shipunova, Daria B. Trushina, Sergey M. Deyev, Dmitry A. Dolgikh, Mikhail P. Kirpichnikov, Marine E. Gasparian
Published 2020-04-01

Stabilization of Nucleosomes by Histone Tails and by FACT Revealed by spFRET Microscopy

by Maria E. Valieva, Nadezhda S. Gerasimova, Kseniya S. Kudryashova, Anastasia L. Kozlova, Mikhail P. Kirpichnikov, Qi Hu, Maria Victoria Botuyan, Georges Mer, Alexey V. Feofanov, Vasily M. Studitsky
Published 2017-01-01

Genetically Modified DR5-Specific TRAIL Variant DR5-B Revealed Dual Antitumor and Protumoral Effect in Colon Cancer Xenografts and an Improved Pharmacokinetic Profile

by Anne V. Yagolovich, Artem A. Artykov, Tatiana A. Karmakova, Maria S. Vorontsova, Andrey A. Pankratov, Alexander A. Andreev-Andrievsky, Dmitry A. Dolgikh, Mikhail P. Kirpichnikov, Marine E. Gasparian
Published 2020-04-01

Engineering of Thermal Stability in a Cold-Active Oligo-1,6-Glucosidase from <i>Exiguobacterium sibiricum</i> with Unusual Amino Acid Content

by Yana Y. Berlina, Lada E. Petrovskaya, Elena A. Kryukova, Lyudmila N. Shingarova, Sultan Sh. Gapizov, Mariya V. Kryukova, Elizaveta M. Rivkina, Mikhail P. Kirpichnikov, Dmitry A. Dolgikh
Published 2021-08-01

N-Terminal Tagging with GFP Enhances Selectivity of Agitoxin 2 to Kv1.3-Channel Binding Site

by Oksana V. Nekrasova, Alexandra L. Primak, Anastasia A. Ignatova, Valery N. Novoseletsky, Olga V. Geras’kina, Ksenia S. Kudryashova, Sergey A. Yakimov, Mikhail P. Kirpichnikov, Alexander S. Arseniev, Alexey V. Feofanov
Published 2020-12-01

New insight into the mechanism of mitochondrial cytochrome c function.

by Rita V Chertkova, Nadezda A Brazhe, Tatiana V Bryantseva, Alexey N Nekrasov, Dmitry A Dolgikh, Alexander I Yusipovich, Olga Sosnovtseva, Georgy V Maksimov, Andrei B Rubin, Mikhail P Kirpichnikov
Published 2017-01-01

Cell-Free Expression of Sodium Channel Domains for Pharmacology Studies. Noncanonical Spider Toxin Binding Site in the Second Voltage-Sensing Domain of Human Nav1.4 Channel

by Mikhail Yu. Myshkin, Roope Männikkö, Olesya A. Krumkacheva, Dmitrii S. Kulbatskii, Anton O. Chugunov, Anton O. Chugunov, Anton O. Chugunov, Antonina A. Berkut, Alexander S. Paramonov, Mikhail A. Shulepko, Matvey V. Fedin, Michael G. Hanna, Dimitri M. Kullmann, Elena G. Bagryanskaya, Alexander S. Arseniev, Alexander S. Arseniev, Mikhail P. Kirpichnikov, Mikhail P. Kirpichnikov, Ekaterina N. Lyukmanova, Ekaterina N. Lyukmanova, Alexander A. Vassilevski, Alexander A. Vassilevski, Zakhar O. Shenkarev, Zakhar O. Shenkarev
Published 2019-09-01

Crystal structure of PMGL2 esterase from the hormone-sensitive lipase family with GCSAG motif around the catalytic serine.

by Konstantin M Boyko, Marya V Kryukova, Lada E Petrovskaya, Alena Y Nikolaeva, Dmitry A Korzhenevsky, Ksenia A Novototskaya-Vlasova, Elizaveta M Rivkina, Dmitry A Dolgikh, Mikhail P Kirpichnikov, Vladimir O Popov
Published 2020-01-01

Amino Acid Substitutions in the Non-Ordered Ω-Loop 70–85 Affect Electron Transfer Function and Secondary Structure of Mitochondrial Cytochrome <i>c</i>

by Rita V. Chertkova, Tatyana V. Bryantseva, Nadezhda A. Brazhe, Kseniya S. Kudryashova, Victor V. Revin, Alexei N. Nekrasov, Alexander I. Yusipovich, Alexey R. Brazhe, Andrew B. Rubin, Dmitry A. Dolgikh, Mikhail P. Kirpichnikov, Georgy V. Maksimov
Published 2021-08-01

Structural and Biochemical Characterization of a Cold-Active PMGL3 Esterase with Unusual Oligomeric Structure

by Konstantin M. Boyko, Mariya V. Kryukova, Lada E. Petrovskaya, Elena A. Kryukova, Alena Y. Nikolaeva, Dmitry A. Korzhenevsky, Galina Yu. Lomakina, Ksenia A. Novototskaya-Vlasova, Elizaveta M. Rivkina, Dmitry A. Dolgikh, Mikhail P. Kirpichnikov, Vladimir O. Popov
Published 2021-01-01

Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of α7 Nicotinic Acetylcholine Receptor.

by Ekaterina N Lyukmanova, Mikhail A Shulepko, Denis Kudryavtsev, Maxim L Bychkov, Dmitrii S Kulbatskii, Igor E Kasheverov, Maria V Astapova, Alexey V Feofanov, Morten S Thomsen, Jens D Mikkelsen, Zakhar O Shenkarev, Victor I Tsetlin, Dmitry A Dolgikh, Mikhail P Kirpichnikov
Published 2016-01-01

Role of hydrogen bond alternation and charge transfer states in photoactivation of the Orange Carotenoid Protein

by Igor A. Yaroshevich, Eugene G. Maksimov, Nikolai N. Sluchanko, Dmitry V. Zlenko, Alexey V. Stepanov, Ekaterina A. Slutskaya, Yury B. Slonimskiy, Viacheslav S. Botnarevskii, Alina Remeeva, Ivan Gushchin, Kirill Kovalev, Valentin I. Gordeliy, Ivan V. Shelaev, Fedor E. Gostev, Dmitry Khakhulin, Vladimir V. Poddubnyy, Timofey S. Gostev, Dmitry A. Cherepanov, Tomáš Polívka, Miroslav Kloz, Thomas Friedrich, Vladimir Z. Paschenko, Victor A. Nadtochenko, Andrew B. Rubin, Mikhail P. Kirpichnikov
Published 2021-05-01