Combination of TRAIL with bortezomib shifted apoptotic signaling from DR4 to DR5 death receptor by selective internalization and degradation of DR4.

by Maxim L Bychkov, Marine E Gasparian, Dmitry A Dolgikh, Mikhail P Kirpichnikov
Published 2014-01-01

Death Receptors DR4 and DR5 Undergo Spontaneous and Ligand-Mediated Endocytosis and Recycling Regardless of the Sensitivity of Cancer Cells to TRAIL

by Artem A. Artykov, Anne V. Yagolovich, Anne V. Yagolovich, Dmitry A. Dolgikh, Dmitry A. Dolgikh, Mikhail P. Kirpichnikov, Mikhail P. Kirpichnikov, Daria B. Trushina, Marine E. Gasparian
Published 2021-09-01

Chemotherapeutic Agents Sensitize Resistant Cancer Cells to the DR5-Specific Variant DR5-B more Efficiently than to TRAIL by Modulating the Surface Expression of Death and Decoy Re...

by Аrtem А. Аrtykov, Dmitry A. Belov, Victoria O. Shipunova, Daria B. Trushina, Sergey M. Deyev, Dmitry A. Dolgikh, Mikhail P. Kirpichnikov, Marine E. Gasparian
Published 2020-04-01

Genetically Modified DR5-Specific TRAIL Variant DR5-B Revealed Dual Antitumor and Protumoral Effect in Colon Cancer Xenografts and an Improved Pharmacokinetic Profile

by Anne V. Yagolovich, Artem A. Artykov, Tatiana A. Karmakova, Maria S. Vorontsova, Andrey A. Pankratov, Alexander A. Andreev-Andrievsky, Dmitry A. Dolgikh, Mikhail P. Kirpichnikov, Marine E. Gasparian
Published 2020-04-01

Engineering of Thermal Stability in a Cold-Active Oligo-1,6-Glucosidase from <i>Exiguobacterium sibiricum</i> with Unusual Amino Acid Content

by Yana Y. Berlina, Lada E. Petrovskaya, Elena A. Kryukova, Lyudmila N. Shingarova, Sultan Sh. Gapizov, Mariya V. Kryukova, Elizaveta M. Rivkina, Mikhail P. Kirpichnikov, Dmitry A. Dolgikh
Published 2021-08-01

New insight into the mechanism of mitochondrial cytochrome c function.

by Rita V Chertkova, Nadezda A Brazhe, Tatiana V Bryantseva, Alexey N Nekrasov, Dmitry A Dolgikh, Alexander I Yusipovich, Olga Sosnovtseva, Georgy V Maksimov, Andrei B Rubin, Mikhail P Kirpichnikov
Published 2017-01-01

Crystal structure of PMGL2 esterase from the hormone-sensitive lipase family with GCSAG motif around the catalytic serine.

by Konstantin M Boyko, Marya V Kryukova, Lada E Petrovskaya, Alena Y Nikolaeva, Dmitry A Korzhenevsky, Ksenia A Novototskaya-Vlasova, Elizaveta M Rivkina, Dmitry A Dolgikh, Mikhail P Kirpichnikov, Vladimir O Popov
Published 2020-01-01

Amino Acid Substitutions in the Non-Ordered Ω-Loop 70–85 Affect Electron Transfer Function and Secondary Structure of Mitochondrial Cytochrome <i>c</i>

by Rita V. Chertkova, Tatyana V. Bryantseva, Nadezhda A. Brazhe, Kseniya S. Kudryashova, Victor V. Revin, Alexei N. Nekrasov, Alexander I. Yusipovich, Alexey R. Brazhe, Andrew B. Rubin, Dmitry A. Dolgikh, Mikhail P. Kirpichnikov, Georgy V. Maksimov
Published 2021-08-01

Structural and Biochemical Characterization of a Cold-Active PMGL3 Esterase with Unusual Oligomeric Structure

by Konstantin M. Boyko, Mariya V. Kryukova, Lada E. Petrovskaya, Elena A. Kryukova, Alena Y. Nikolaeva, Dmitry A. Korzhenevsky, Galina Yu. Lomakina, Ksenia A. Novototskaya-Vlasova, Elizaveta M. Rivkina, Dmitry A. Dolgikh, Mikhail P. Kirpichnikov, Vladimir O. Popov
Published 2021-01-01

Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of α7 Nicotinic Acetylcholine Receptor.

by Ekaterina N Lyukmanova, Mikhail A Shulepko, Denis Kudryavtsev, Maxim L Bychkov, Dmitrii S Kulbatskii, Igor E Kasheverov, Maria V Astapova, Alexey V Feofanov, Morten S Thomsen, Jens D Mikkelsen, Zakhar O Shenkarev, Victor I Tsetlin, Dmitry A Dolgikh, Mikhail P Kirpichnikov
Published 2016-01-01