Broadly Neutralizing Antibodies for HIV-1 Prevention

by Stephen R. Walsh, Michael S. Seaman
Published 2021-07-01

Computational prediction of broadly neutralizing HIV-1 antibody epitopes from neutralization activity data.

by Andrew L Ferguson, Emilia Falkowska, Laura M Walker, Michael S Seaman, Dennis R Burton, Arup K Chakraborty
Published 2013-01-01

Discovery of O-Linked Carbohydrate on HIV-1 Envelope and Its Role in Shielding against One Category of Broadly Neutralizing Antibodies

by Zachary A. Silver, Aristotelis Antonopoulos, Stuart M. Haslam, Anne Dell, Gordon M. Dickinson, Michael S. Seaman, Ronald C. Desrosiers
Published 2020-02-01

Adenovirus prime, Env protein boost vaccine protects against neutralization-resistant SIVsmE660 variants in rhesus monkeys

by Brandon F. Keele, Wenjun Li, Erica N. Borducchi, Joseph P. Nkolola, Peter Abbink, Bing Chen, Michael S. Seaman, Dan H. Barouch
Published 2017-06-01

Anti-V3 monoclonal antibodies display broad neutralizing activities against multiple HIV-1 subtypes.

by Catarina E Hioe, Terri Wrin, Michael S Seaman, Xuesong Yu, Blake Wood, Steve Self, Constance Williams, Miroslaw K Gorny, Susan Zolla-Pazner
Published 2010-04-01

Memory B cell antibodies to HIV-1 gp140 cloned from individuals infected with clade A and B viruses.

by Hugo Mouquet, Florian Klein, Johannes F Scheid, Malte Warncke, John Pietzsch, Thiago Y K Oliveira, Klara Velinzon, Michael S Seaman, Michel C Nussenzweig
Published 2011-01-01

Thy1+ NK [corrected] cells from vaccinia virus-primed mice confer protection against vaccinia virus challenge in the absence of adaptive lymphocytes.

by Geoffrey O Gillard, Maytal Bivas-Benita, Avi-Hai Hovav, Lauren E Grandpre, Michael W Panas, Michael S Seaman, Barton F Haynes, Norman L Letvin
Published 2011-08-01

Characterization of neutralizing profiles in HIV-1 infected patients from whom the HJ16, HGN194 and HK20 mAbs were obtained.

by Sunita S Balla-Jhagjhoorsingh, Betty Willems, Liesbeth Heyndrickx, Leo Heyndrickx, Katleen Vereecken, Wouter Janssens, Michael S Seaman, Davide Corti, Antonio Lanzavecchia, David Davis, Guido Vanham
Published 2011-01-01

Correction: Thy1 Nk Cells from Vaccinia Virus-Primed Mice Confer Protection against Vaccinia Virus Challenge in the Absence of Adaptive Lymphocytes.

by Geoffrey O. Gillard, Maytal Bivas-Benita, Avi-Hai Hovav, Lauren E. Grandpre, Michael W. Panas, Michael S. Seaman, Barton F. Haynes, Norman L. Letvin
Published 2011-08-01

Distinct clonal evolution of B-cells in HIV controllers with neutralizing antibody breadth

by Deniz Cizmeci, Giuseppe Lofano, Evan Rossignol, Anne-Sophie Dugast, Dongkyoon Kim, Guy Cavet, Ngan Nguyen, Yann Chong Tan, Michael S Seaman, Galit Alter, Boris Julg
Published 2021-04-01

Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies

by Haoqing Wang, Harry B Gristick, Louise Scharf, Anthony P West Jr, Rachel P Galimidi, Michael S Seaman, Natalia T Freund, Michel C Nussenzweig, Pamela J Bjorkman
Published 2017-05-01

10E8V2.0/iMab: an engineered membrane-anchored bispecific anti-HIV antibody effective in preventing and treating HIV in humanized mice

by Anastasia Lanzi, Yaoxing Huang, Jian Yu, Xin Yao, Chasity D. Andrews, Lily Tsai, Mili R. Gajjar, Michael S. Seaman, Neal N. Padte, David D. Ho
Published 2016-05-01

Characterization of Co-Formulated High-Concentration Broadly Neutralizing Anti-HIV-1 Monoclonal Antibodies for Subcutaneous Administration

by Vaneet K. Sharma, Bijay Misra, Kevin T. McManus, Sreenivas Avula, Kaliappanadar Nellaiappan, Marina Caskey, Jill Horowitz, Michel C. Nussenzweig, Michael S. Seaman, Indu Javeri, Antu K. Dey
Published 2020-07-01

Structural basis of transmembrane coupling of the HIV-1 envelope glycoprotein

by Alessandro Piai, Qingshan Fu, Yongfei Cai, Fadi Ghantous, Tianshu Xiao, Md Munan Shaik, Hanqin Peng, Sophia Rits-Volloch, Wen Chen, Michael S. Seaman, Bing Chen, James J. Chou
Published 2020-05-01

Contribution of intrinsic reactivity of the HIV-1 envelope glycoproteins to CD4-independent infection and global inhibitor sensitivity.

by Hillel Haim, Bettina Strack, Aemro Kassa, Navid Madani, Liping Wang, Joel R Courter, Amy Princiotto, Kathleen McGee, Beatriz Pacheco, Michael S Seaman, Amos B Smith, Joseph Sodroski
Published 2011-06-01

Different pattern of immunoglobulin gene usage by HIV-1 compared to non-HIV-1 antibodies derived from the same infected subject.

by Liuzhe Li, Xiao-Hong Wang, Sagarika Banerjee, Barbara Volsky, Constance Williams, Diana Virland, Arthur Nadas, Michael S Seaman, Xuemin Chen, Paul Spearman, Susan Zolla-Pazner, Miroslaw K Gorny
Published 2012-01-01

Durable protection against repeated penile exposures to simian-human immunodeficiency virus by broadly neutralizing antibodies

by David A. Garber, Debra R. Adams, Patricia Guenthner, James Mitchell, Kristen Kelley, Till Schoofs, Anna Gazumyan, Martha Nason, Michael S. Seaman, Janet McNicholl, Michel C. Nussenzweig, Walid Heneine
Published 2020-06-01

Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity

by Julie Prigent, Annaëlle Jarossay, Cyril Planchais, Caroline Eden, Jérémy Dufloo, Ayrin Kök, Valérie Lorin, Oxana Vratskikh, Thérèse Couderc, Timothée Bruel, Olivier Schwartz, Michael S. Seaman, Oliver Ohlenschläger, Jordan D. Dimitrov, Hugo Mouquet
Published 2018-05-01

Hinge length contributes to the phagocytic activity of HIV-specific IgG1 and IgG3 antibodies.

by Thach H Chu, Andrew R Crowley, Iara Backes, Cheryl Chang, Matthew Tay, Thomas Broge, Marina Tuyishime, Guido Ferrari, Michael S Seaman, Simone I Richardson, Georgia D Tomaras, Galit Alter, David Leib, Margaret E Ackerman
Published 2020-02-01

Antibody 8ANC195 Reveals a Site of Broad Vulnerability on the HIV-1 Envelope Spike

by Louise Scharf, Johannes F. Scheid, Jeong Hyun Lee, Anthony P. West Jr., Courtney Chen, Han Gao, Priyanthi N.P. Gnanapragasam, René Mares, Michael S. Seaman, Andrew B. Ward, Michel C. Nussenzweig, Pamela J. Bjorkman
Published 2014-05-01