Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons.

by Jonathan Gilley, Michael P Coleman
Published 2010-01-01

Subcellular localization determines the stability and axon protective capacity of axon survival factor Nmnat2.

by Stefan Milde, Jonathan Gilley, Michael P Coleman
Published 2013-01-01

Lipopolysaccharide-induced neuroinflammation induces presynaptic disruption through a direct action on brain tissue involving microglia-derived interleukin 1 beta

by Olivia Sheppard, Michael P. Coleman, Claire S. Durrant
Published 2019-05-01

Sarm1 Deletion, but Not WldS, Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy

by Jonathan Gilley, Richard R. Ribchester, Michael P. Coleman
Published 2017-10-01

Loss of highwire Protects Against the Deleterious Effects of Traumatic Brain Injury in Drosophila Melanogaster

by Ciaran S. Hill, Ciaran S. Hill, Jemeen Sreedharan, Jemeen Sreedharan, Andrea Loreto, David K. Menon, David K. Menon, Michael P. Coleman, Michael P. Coleman
Published 2020-05-01

A Novel NAD Signaling Mechanism in Axon Degeneration and its Relationship to Innate Immunity

by Eleanor L. Hopkins, Weixi Gu, Bostjan Kobe, Michael P. Coleman
Published 2021-07-01

MEK inhibitor U0126 reverses protection of axons from Wallerian degeneration independently of MEK-ERK signaling.

by Catherine Evans, Simon J Cook, Michael P Coleman, Jonathan Gilley
Published 2013-01-01

Absence of SARM1 Rescues Development and Survival of NMNAT2-Deficient Axons

by Jonathan Gilley, Giuseppe Orsomando, Isabel Nascimento-Ferreira, Michael P. Coleman
Published 2015-03-01

Simultaneous single-sample determination of NMNAT isozyme activities in mouse tissues.

by Giuseppe Orsomando, Lucia Cialabrini, Adolfo Amici, Francesca Mazzola, Silverio Ruggieri, Laura Conforti, Lucie Janeckova, Michael P Coleman, Giulio Magni
Published 2012-01-01

The Wlds transgene reduces axon loss in a Charcot-Marie-Tooth disease 1A rat model and nicotinamide delays post-traumatic axonal degeneration

by Gerd Meyer zu Horste, Timo A. Miesbach, Johanna I. Muller, Robert Fledrich, Ruth M. Stassart, Bernd C. Kieseier, Michael P. Coleman, Michael W. Sereda
Published 2011-04-01

Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons

by Teresa Rodríguez-Martín, Amy M. Pooler, Dawn H.W. Lau, Gábor M. Mórotz, Kurt J. De Vos, Jonathan Gilley, Michael P. Coleman, Diane P. Hanger
Published 2016-01-01

Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration

by Andrea Loreto, Ciaran S. Hill, Victoria L. Hewitt, Giuseppe Orsomando, Carlo Angeletti, Jonathan Gilley, Cristiano Lucci, Alvaro Sanchez-Martinez, Alexander J. Whitworth, Laura Conforti, Federico Dajas-Bailador, Michael P. Coleman
Published 2020-02-01

Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue

by Lauren V. C. Miller, Aamir S. Mukadam, Claire S. Durrant, Marina J. Vaysburd, Taxiarchis Katsinelos, Benjamin J. Tuck, Sophie Sanford, Olivia Sheppard, Claire Knox, Shi Cheng, Leo C. James, Michael P. Coleman, William A. McEwan
Published 2021-03-01

Sarm1 deletion suppresses TDP-43-linked motor neuron degeneration and cortical spine loss

by Matthew A. White, Ziqiang Lin, Eugene Kim, Christopher M. Henstridge, Emiliano Pena Altamira, Camille K. Hunt, Ella Burchill, Isobel Callaghan, Andrea Loreto, Heledd Brown-Wright, Richard Mead, Camilla Simmons, Diana Cash, Michael P. Coleman, Jemeen Sreedharan
Published 2019-10-01