Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons.

by Jonathan Gilley, Michael P Coleman
Published 2010-01-01

Subcellular localization determines the stability and axon protective capacity of axon survival factor Nmnat2.

by Stefan Milde, Jonathan Gilley, Michael P Coleman
Published 2013-01-01

Sarm1 Deletion, but Not WldS, Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy

by Jonathan Gilley, Richard R. Ribchester, Michael P. Coleman
Published 2017-10-01

MEK inhibitor U0126 reverses protection of axons from Wallerian degeneration independently of MEK-ERK signaling.

by Catherine Evans, Simon J Cook, Michael P Coleman, Jonathan Gilley
Published 2013-01-01

Absence of SARM1 Rescues Development and Survival of NMNAT2-Deficient Axons

by Jonathan Gilley, Giuseppe Orsomando, Isabel Nascimento-Ferreira, Michael P. Coleman
Published 2015-03-01

Nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2) regulates axon integrity in the mouse embryo.

by Amy N Hicks, Diego Lorenzetti, Jonathan Gilley, Baisong Lu, Karl-Erik Andersson, Carol Miligan, Paul A Overbeek, Ronald Oppenheim, Colin E Bishop
Published 2012-01-01

Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons

by Teresa Rodríguez-Martín, Amy M. Pooler, Dawn H.W. Lau, Gábor M. Mórotz, Kurt J. De Vos, Jonathan Gilley, Michael P. Coleman, Diane P. Hanger
Published 2016-01-01

Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration

by Andrea Loreto, Ciaran S. Hill, Victoria L. Hewitt, Giuseppe Orsomando, Carlo Angeletti, Jonathan Gilley, Cristiano Lucci, Alvaro Sanchez-Martinez, Alexander J. Whitworth, Laura Conforti, Federico Dajas-Bailador, Michael P. Coleman
Published 2020-02-01