A Short Peptide Inhibitor as an Activity-Based Probe for Matriptase-2

by Martin Mangold, Michael Gütschow, Marit Stirnberg
Published 2018-05-01

Promiscuous Ligands from Experimentally Determined Structures, Binding Conformations, and Protein Family-Dependent Interaction Hotspots

by Erik Gilberg, Michael Gütschow, Jürgen Bajorath
Published 2019-01-01

Synthesis and Crystal Structure of Benzyl [(1S)-1-(5-amino-1,3,4-oxadiazol-2-yl)-2-phenylethyl]carbamate

by Reik Löser, Martin Nieger, Michael Gütschow
Published 2012-08-01

E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points

by Aleša Bricelj, Christian Steinebach, Robert Kuchta, Michael Gütschow, Izidor Sosič
Published 2021-07-01

Cholesterol esterase action on human high density lipoproteins and inhibition studies: detection by MALDI-TOF MS

by Olaf Zschörnig, Markus Pietsch, Rosemarie Süß, Jürgen Schiller, Michael Gütschow
Published 2005-04-01

Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages

by Johnathan Canton, Daniel Schlam, Christian Breuer, Michael Gütschow, Michael Glogauer, Sergio Grinstein
Published 2016-04-01

Convergent Synthesis of Two Fluorescent Ebselen-Coumarin Heterodimers

by Jim Küppers, Anna Christina Schulz-Fincke, Jerzy Palus, Mirosław Giurg, Jacek Skarżewski, Michael Gütschow
Published 2016-07-01

3,1-Benzothiazines, 1,4-Benzodioxines and 1,4-Benzoxazines as Inhibitors of Matriptase-2: Outcome of a Focused Screening Approach

by Polya G. Roydeva, Anna-Madeleine Beckmann, Marit Stirnberg, Jožko Cesar, Danijel Kikelj, Janez Ilaš, Michael Gütschow
Published 2016-01-01

Development of Fluorescent and Biotin Probes Targeting NLRP3

by Tim Keuler, Karl Gatterdam, Anil Akbal, Marta Lovotti, Michael Marleaux, Matthias Geyer, Eicke Latz, Michael Gütschow
Published 2021-04-01

Label-Free Whole Cell Biosensing for High-Throughput Discovery of Activators and Inhibitors Targeting G Protein-Activated Inwardly Rectifying Potassium Channels

by Katrin M. Krebs, Eva M. Pfeil, Katharina Simon, Manuel Grundmann, Felix Häberlein, Oscar M. Bautista-Aguilera, Michael Gütschow, C. David Weaver, Bernd K. Fleischmann, Evi Kostenis
Published 2018-11-01

Antiangiogenic Activity and in Silico Cereblon Binding Analysis of Novel Thalidomide Analogs

by Megan L. Peach, Shaunna L. Beedie, Cindy H. Chau, Matthew K. Collins, Suzana Markolovic, Weiming Luo, David Tweedie, Christian Steinebach, Nigel H. Greig, Michael Gütschow, Neil Vargesson, Marc C. Nicklaus, William D. Figg
Published 2020-12-01

Mapping the S1 and S1' subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents.

by Lorenzo Cianni, Carina Lemke, Erik Gilberg, Christian Feldmann, Fabiana Rosini, Fernanda Dos Reis Rocho, Jean F R Ribeiro, Daiane Y Tezuka, Carla D Lopes, Sérgio de Albuquerque, Jürgen Bajorath, Stefan Laufer, Andrei Leitão, Michael Gütschow, Carlos A Montanari
Published 2020-03-01

Thioesterase-mediated side chain transesterification generates potent Gq signaling inhibitor FR900359

by Cornelia Hermes, René Richarz, Daniel A. Wirtz, Julian Patt, Wiebke Hanke, Stefan Kehraus, Jan Hendrik Voß, Jim Küppers, Tsubasa Ohbayashi, Vigneshwaran Namasivayam, Judith Alenfelder, Asuka Inoue, Peter Mergaert, Michael Gütschow, Christa E. Müller, Evi Kostenis, Gabriele M. König, Max Crüsemann
Published 2021-01-01

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–2

by Diego Muñoz-Torrero, Arduino A. Mangoni, Hong Liu, Christopher Hulme, Jarkko Rautio, Rafik Karaman, Maria Emília de Sousa, Katalin Prokai-Tatrai, Jean-Marc Sabatier, Carlo Siciliano, F. Javier Luque, George Kokotos, Rino Ragno, Simona Collina, Catherine Guillou, Michael Gütschow, Luigi A. Agrofoglio
Published 2017-12-01

Solubility and Stability Enhanced Oral Formulations for the Anti-Infective Corallopyronin A

by Anna K. Krome, Tim Becker, Stefan Kehraus, Andrea Schiefer, Christian Steinebach, Tilman Aden, Stefan J. Frohberger, Álvaro López Mármol, Dnyaneshwar Kapote, Rolf Jansen, Lillibeth Chaverra-Muñoz, Marc P. Hübner, Kenneth Pfarr, Thomas Hesterkamp, Marc Stadler, Michael Gütschow, Gabriele M. König, Achim Hoerauf, Karl G. Wagner
Published 2020-11-01

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-3

by Arduino A. Mangoni, Tiziano Tuccinardi, Simona Collina, Jean Jacques Vanden Eynde, Diego Muñoz-Torrero, Rafik Karaman, Carlo Siciliano, Maria Emília de Sousa, Katalin Prokai-Tatrai, Jarkko Rautio, Catherine Guillou, Michael Gütschow, Stefania Galdiero, Hong Liu, Luigi A. Agrofoglio, Jean-Marc Sabatier, Christopher Hulme, George Kokotos, Qidong You, Paula A. C. Gomes
Published 2018-06-01

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–4

by Arduino A Mangoni, Catherine Guillou, Jean Jacques Vanden Eynde, Christopher Hulme, Josef Jampilek, Wei Li, Katalin Prokai-Tatrai, Jarkko Rautio, Simona Collina, Tiziano Tuccinardi, Maria Emília Sousa, Jean-Marc Sabatier, Stefania Galdiero, Rafik Karaman, George Kokotos, Giangiacomo Torri, F. Javier Luque, M. Helena Vasconcelos, Dimitra Hadjipavlou-Litina, Carlo Siciliano, Michael Gütschow, Rino Ragno, Paula A. C. Gomes, Luigi A. Agrofoglio, Diego Muñoz-Torrero
Published 2018-12-01

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–5

by Arduino A. Mangoni, Jean Jacques Vanden Eynde, Josef Jampilek, Dimitra Hadjipavlou-Litina, Hong Liu, Jóhannes Reynisson, Maria Emília Sousa, Paula A. C. Gomes, Katalin Prokai-Tatrai, Tiziano Tuccinardi, Jean-Marc Sabatier, F. Javier Luque, Jarkko Rautio, Rafik Karaman, M. Helena Vasconcelos, Sandra Gemma, Stefania Galdiero, Christopher Hulme, Simona Collina, Michael Gütschow, George Kokotos, Carlo Siciliano, Raffaele Capasso, Luigi A. Agrofoglio, Rino Ragno, Diego Muñoz-Torrero
Published 2019-06-01

Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury

by Wulf Tonnus, Claudia Meyer, Christian Steinebach, Alexia Belavgeni, Anne von Mässenhausen, Nadia Zamora Gonzalez, Francesca Maremonti, Florian Gembardt, Nina Himmerkus, Markus Latk, Sophie Locke, Julian Marschner, Wenjun Li, Spencer Short, Sebastian Doll, Irina Ingold, Bettina Proneth, Christoph Daniel, Nazanin Kabgani, Rafael Kramann, Stephen Motika, Paul J. Hergenrother, Stefan R. Bornstein, Christian Hugo, Jan Ulrich Becker, Kerstin Amann, Hans-Joachim Anders, Daniel Kreisel, Derek Pratt, Michael Gütschow, Marcus Conrad, Andreas Linkermann
Published 2021-07-01

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–6

by Jean Jacques Vanden Eynde, Arduino A. Mangoni, Jarkko Rautio, Jérôme Leprince, Yasu-Taka Azuma, Alfonso T. García-Sosa, Christopher Hulme, Josef Jampilek, Rafik Karaman, Wei Li, Paula A. C. Gomes, Dimitra Hadjipavlou-Litina, Raffaele Capasso, Athina Geronikaki, Laura Cerchia, Jean-Marc Sabatier, Rino Ragno, Tiziano Tuccinardi, Andrea Trabocchi, Jean-Yves Winum, F. Javier Luque, Katalin Prokai-Tatrai, Mariana Spetea, Michael Gütschow, Ivan Kosalec, Catherine Guillou, M. Helena Vasconcelos, George Kokotos, Giulio Rastelli, Maria Emília de Sousa, Clementina Manera, Sandra Gemma, Stefano Mangani, Carlo Siciliano, Stefania Galdiero, Hong Liu, Peter J. H. Scott, Cristóbal de los Ríos, Luigi A. Agrofoglio, Simona Collina, Rita C. Guedes, Diego Muñoz-Torrero
Published 2019-12-01