Enhanced ER proteostasis and temperature differentially impact the mutational tolerance of influenza hemagglutinin

by Angela M Phillips, Michael B Doud, Luna O Gonzalez, Vincent L Butty, Yu-Shan Lin, Jesse D Bloom, Matthew D Shoulders
Published 2018-09-01

CRISPR/Cas9 editing to generate a heterozygous COL2A1 p.G1170S human chondrodysplasia iPSC line, MCRIi019-A-2, in a control iPSC line, MCRIi019-A

by Louise H.W. Kung, Lisa Sampurno, Kathryn M. Yammine, Alison Graham, Penny McDonald, John F. Bateman, Matthew D. Shoulders, Shireen R. Lamandé
Published 2020-10-01

A cysteine-based molecular code informs collagen C-propeptide assembly

by Andrew S. DiChiara, Rasia C. Li, Patreece H. Suen, Azade S. Hosseini, Rebecca J. Taylor, Alexander F. Weickhardt, Diya Malhotra, Darrell R. McCaslin, Matthew D. Shoulders
Published 2018-10-01

Host proteostasis modulates influenza evolution

by Angela M Phillips, Luna O Gonzalez, Emmanuel E Nekongo, Anna I Ponomarenko, Sean M McHugh, Vincent L Butty, Stuart S Levine, Yu-Shan Lin, Leonid A Mirny, Matthew D Shoulders
Published 2017-09-01

Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments

by Matthew D. Shoulders, Lisa M. Ryno, Joseph C. Genereux, James J. Moresco, Patricia G. Tu, Chunlei Wu, John R. Yates, III, Andrew I. Su, Jeffery W. Kelly, R. Luke Wiseman
Published 2013-04-01

Destabilized adaptive influenza variants critical for innate immune system escape are potentiated by host chaperones.

by Angela M Phillips, Anna I Ponomarenko, Kenny Chen, Orr Ashenberg, Jiayuan Miao, Sean M McHugh, Vincent L Butty, Charles A Whittaker, Christopher L Moore, Jesse D Bloom, Yu-Shan Lin, Matthew D Shoulders
Published 2018-09-01

Directed evolution in human cells via adenoviral replication

by Berman, Chet Michael.
Published 2019

Chaperoning viral protein evolution

by Phillips, Angela Marie, Ph. D. Massachusetts Institute of Technology
Published 2018

Distant chaperones and N-glycan signals : new mechanisms of secretory pathway proteostasis

by Wong, Madeline Y
Published 2019

Understanding collagen-l folding and misfolding

by Taylor, Rebecca J. S.B. Massachusetts Institute of Technology
Published 2015

Type I collagen proteostasis

by DiChiara, Andrew Stephen
Published 2018

Methods to study protein folding and evolution in vivo

by Moore, Christopher Lawrence
Published 2018