Evaluating Sphingosine and its Analogues as Potential Alternatives for Aggressive Lymphoma Treatment

by Constantin Bode, Max Berlin, Franziska Röstel, Bianca Teichmann, Markus H. Gräler
Published 2014-11-01

Sphingosine 1-Phosphate in Blood: Function, Metabolism, and Fate

by Andreas V. Thuy, Christina-Maria Reimann, Nasr Y. A. Hemdan, Markus H. Gräler
Published 2014-06-01

Inflammatory Conditions Disrupt Constitutive Endothelial Cell Barrier Stabilization by Alleviating Autonomous Secretion of Sphingosine 1-Phosphate

by Jefri Jeya Paul, Cynthia Weigel, Tina Müller, Regine Heller, Sarah Spiegel, Markus H. Gräler
Published 2020-04-01

Loss of sphingosine 1-phosphate (S1P) in septic shock is predominantly caused by decreased levels of high-density lipoproteins (HDL)

by Martin Sebastian Winkler, Konstantin B. Märtz, Axel Nierhaus, Günter Daum, Edzard Schwedhelm, Stefan Kluge, Markus H. Gräler
Published 2019-04-01

Acid Sphingomyelinase Inhibition Stabilizes Hepatic Ceramide Content and Improves Hepatic Biotransformation Capacity in a Murine Model of Polymicrobial Sepsis

by Ha-Yeun Chung, C. Julius Witt, Jorge Hurtado-Oliveros, Jonathan Wickel, Markus H. Gräler, Amelie Lupp, Ralf A. Claus
Published 2018-10-01

Regulation of ABCA1-mediated cholesterol efflux by sphingosine-1-phosphate signaling in macrophages

by Mithila Vaidya, Julian A. Jentsch, Susann Peters, Petra Keul, Sarah Weske, Markus H. Gräler, Emil Mladenov, George Iliakis, Gerd Heusch, Bodo Levkau
Published 2019-03-01

Acid Sphingomyelinase Promotes Endothelial Stress Response in Systemic Inflammation and Sepsis

by Ha-Yeun Chung, Daniel C Hupe, Gordon P Otto, Marcel Sprenger, Alexander C Bunck, Michael J Dorer, Clemens L Bockmeyer, Hans-Peter Deigner, Markus H Gräler, Ralf A Claus
Published 2016-06-01

S1P lyase inhibition protects against sepsis by promoting disease tolerance via the S1P/S1PR3 axis

by Cynthia Weigel, Sören S. Hüttner, Kristin Ludwig, Nadine Krieg, Susann Hofmann, Nathalie H. Schröder, Linda Robbe, Stefan Kluge, Axel Nierhaus, Martin S. Winkler, Ignacio Rubio, Julia von Maltzahn, Sarah Spiegel, Markus H. Gräler
Published 2020-08-01

Targeted delivery of a phosphoinositide 3‐kinase γ inhibitor to restore organ function in sepsis

by Adrian T Press, Petra Babic, Bianca Hoffmann, Tina Müller, Wanling Foo, Walter Hauswald, Jovana Benecke, Martina Beretta, Zoltán Cseresnyés, Stephanie Hoeppener, Ivo Nischang, Sina M Coldewey, Markus H Gräler, Reinhard Bauer, Falk Gonnert, Nikolaus Gaßler, Reinhard Wetzker, Marc Thilo Figge, Ulrich S Schubert, Michael Bauer
Published 2021-10-01

Identification of Brain-Specific Treatment Effects in NPC1 Disease by Focusing on Cellular and Molecular Changes of Sphingosine-1-Phosphate Metabolism

by Anne Gläser, Franziska Hammerl, Markus H. Gräler, Sina M. Coldewey, Christin Völkner, Moritz J. Frech, Fan Yang, Jiankai Luo, Eric Tönnies, Oliver von Bohlen und Halbach, Nicola Brandt, Diana Heimes, Anna-Maria Neßlauer, Georg Christoph Korenke, Marta Owczarek-Lipska, John Neidhardt, Arndt Rolfs, Andreas Wree, Martin Witt, Anja Ursula Bräuer
Published 2020-06-01