Low-Zone IL-2 Signaling: Fusion Proteins Containing Linked CD25 and IL-2 Domains Sustain Tolerogenic Vaccination in vivo and Promote Dominance of FOXP3+ Tregs in vitro

by Kayla B. DeOca, Cody D. Moorman, Brandon L. Garcia, Mark D. Mannie
Published 2020-09-01

A GM-CSF-neuroantigen tolerogenic vaccine elicits inefficient antigen recognition events below the CD40L triggering threshold to expand CD4+ CD25+ FOXP3+ Tregs that inhibit experim...

by Cody D. Moorman, Alexander G. Bastian, Kayla B. DeOca, Mark D. Mannie
Published 2020-06-01

Cytokine-neuroantigen fusion proteins as a new class of tolerogenic, therapeutic vaccines for treatment of inflammatory demyelinating disease in rodent models of multiple sclerosis

by Mark D. Mannie, J. Lori Blanchfield, S. M. Touhidul eIslam, Derek J. Abbott
Published 2012-08-01

Partial CD25 Antagonism Enables Dominance of Antigen-Inducible CD25high FOXP3+ Regulatory T Cells As a Basis for a Regulatory T Cell-Based Adoptive Immunotherapy

by Daniel S. Wilkinson, Debjani Ghosh, Rebecca A. Nickle, Cody D. Moorman, Mark D. Mannie
Published 2017-12-01

A GMCSF-Neuroantigen Tolerogenic Vaccine Elicits Systemic Lymphocytosis of CD4+ CD25high FOXP3+ Regulatory T Cells in Myelin-Specific TCR Transgenic Mice Contingent Upon Low-Effici...

by Cody D. Moorman, Alan D. Curtis, Alexander G. Bastian, Sarah E. Elliott, Mark D. Mannie
Published 2019-01-01

The extracellular domain of myelin oligodendrocyte glycoprotein elicits atypical experimental autoimmune encephalomyelitis in rat and Macaque species.

by Alan D Curtis, Najla Taslim, Shaun P Reece, Elena Grebenciucova, Richard H Ray, Matthew D Rosenbaum, Robert L Wardle, Michael R Van Scott, Mark D Mannie
Published 2014-01-01