Low-Zone IL-2 Signaling: Fusion Proteins Containing Linked CD25 and IL-2 Domains Sustain Tolerogenic Vaccination in vivo and Promote Dominance of FOXP3+ Tregs in vitro

by Kayla B. DeOca, Cody D. Moorman, Brandon L. Garcia, Mark D. Mannie
Published 2020-09-01

A GM-CSF-neuroantigen tolerogenic vaccine elicits inefficient antigen recognition events below the CD40L triggering threshold to expand CD4+ CD25+ FOXP3+ Tregs that inhibit experim...

by Cody D. Moorman, Alexander G. Bastian, Kayla B. DeOca, Mark D. Mannie
Published 2020-06-01