Mouse models for V103I and I251L gain of function variants of the human MC4R display decreased adiposity but are not protected against a hypercaloric diet

by Daniela Rojo, Clara McCarthy, Jesica Raingo, Marcelo Rubinstein
Published 2020-12-01

The transcriptional regulator PRDM12 is critical for Pomc expression in the mouse hypothalamus and controlling food intake, adiposity, and body weight

by Clara E. Hael, Daniela Rojo, Daniela P. Orquera, Malcolm J. Low, Marcelo Rubinstein
Published 2020-04-01

Hypothalamic Pomc expression restricted to GABAergic neurons suppresses Npy overexpression and restores food intake in obese mice

by Milagros Trotta, Estefanía Pilar Bello, Ramiro Alsina, María Belén Tavella, José Luis Ferrán, Marcelo Rubinstein, Viviana Florencia Bumaschny
Published 2020-07-01

Ancient exaptation of a CORE-SINE retroposon into a highly conserved mammalian neuronal enhancer of the proopiomelanocortin gene.

by Andrea M Santangelo, Flávio S J de Souza, Lucía F Franchini, Viviana F Bumaschny, Malcolm J Low, Marcelo Rubinstein
Published 2007-10-01

Segregation of brain and organizer precursors is differentially regulated by Nodal signaling at blastula stage

by Aitana M. Castro Colabianchi, María B. Tavella, Laura E. Boyadjián López, Marcelo Rubinstein, Lucía F. Franchini, Silvia L. López
Published 2021-02-01

Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity

by Kavaljit H. Chhabra, Jessica M. Adams, Graham L. Jones, Miho Yamashita, Martin Schlapschy, Arne Skerra, Marcelo Rubinstein, Malcolm J. Low
Published 2016-10-01

A Mechanism Linking Two Known Vulnerability Factors for Alcohol Abuse: Heightened Alcohol Stimulation and Low Striatal Dopamine D2 Receptors

by Miriam E. Bocarsly, Daniel da Silva e Silva, Vanessa Kolb, Kathryn D. Luderman, Sannidhi Shashikiran, Marcelo Rubinstein, David R. Sibley, Lauren K. Dobbs, Veronica A. Alvarez
Published 2019-10-01

Partially redundant enhancers cooperatively maintain Mammalian pomc expression above a critical functional threshold.

by Daniel D Lam, Flavio S J de Souza, Sofia Nasif, Miho Yamashita, Rodrigo López-Leal, Veronica Otero-Corchon, Kana Meece, Harini Sampath, Aaron J Mercer, Sharon L Wardlaw, Marcelo Rubinstein, Malcolm J Low
Published 2015-02-01

Functional and molecular heterogeneity of D2R neurons along dorsal ventral axis in the striatum

by Emma Puighermanal, Laia Castell, Anna Esteve-Codina, Su Melser, Konstantin Kaganovsky, Charleine Zussy, Jihane Boubaker-Vitre, Marta Gut, Stephanie Rialle, Christoph Kellendonk, Elisenda Sanz, Albert Quintana, Giovanni Marsicano, Miquel Martin, Marcelo Rubinstein, Jean-Antoine Girault, Jun B. Ding, Emmanuel Valjent
Published 2020-04-01

Lorcaserin improves glycemic control via a melanocortin neurocircuit

by Luke K. Burke, Emmanuel Ogunnowo-Bada, Teodora Georgescu, Claudia Cristiano, Pablo B. Martinez de Morentin, Lourdes Valencia Torres, Giuseppe D'Agostino, Christine Riches, Nicholas Heeley, Yue Ruan, Marcelo Rubinstein, Malcolm J. Low, Martin G. Myers, Justin J. Rochford, Mark L. Evans, Lora K. Heisler
Published 2017-10-01

Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons

by Luke K. Burke, Barbora Doslikova, Giuseppe D'Agostino, Megan Greenwald-Yarnell, Teodora Georgescu, Raffaella Chianese, Pablo B. Martinez de Morentin, Emmanuel Ogunnowo-Bada, Celine Cansell, Lourdes Valencia-Torres, Alastair S. Garfield, John Apergis-Schoute, Daniel D. Lam, John R. Speakman, Marcelo Rubinstein, Malcolm J. Low, Justin J. Rochford, Martin G. Myers, Mark L. Evans, Lora K. Heisler
Published 2016-03-01