Gene expression profiling reveals a possible role for somatostatin in the innate immune response of the liver

by Jessica M. Adams, Malcolm J. Low
Published 2015-09-01

Unraveling the central proopiomelanocortin neural circuits

by Aaron J. Mercer, Shane T. Hentges, Charles K. Meshul, Charles K. Meshul, Malcolm J. Low, Malcolm J. Low
Published 2013-02-01

Glucose rapidly induces different forms of excitatory synaptic plasticity in hypothalamic POMC neurons.

by Jun Hu, Lin Jiang, Malcolm J Low, Liangyou Rui
Published 2014-01-01

Adult-born proopiomelanocortin neurons derived from Rax-expressing precursors mitigate the metabolic effects of congenital hypothalamic proopiomelanocortin deficiency

by Surbhi, Gábor Wittmann, Malcolm J. Low, Ronald M. Lechan
Published 2021-11-01

The transcriptional regulator PRDM12 is critical for Pomc expression in the mouse hypothalamus and controlling food intake, adiposity, and body weight

by Clara E. Hael, Daniela Rojo, Daniela P. Orquera, Malcolm J. Low, Marcelo Rubinstein
Published 2020-04-01

Decreased sensitivity to the anorectic effects of leptin in mice that lack a Pomc-specific neural enhancer.

by Elisa S Na, Daniel D Lam, Eva Yokosawa, Jessica M Adams, David P Olson, Malcolm J Low
Published 2020-01-01

Hypothalamic POMC deficiency increases circulating adiponectin despite obesity

by Hui Yu, Kavaljit H. Chhabra, Zoe Thompson, Graham L. Jones, Sylee Kiran, Gary Shangguan, Malcolm J. Low
Published 2020-05-01

Reduced renal sympathetic nerve activity contributes to elevated glycosuria and improved glucose tolerance in hypothalamus-specific Pomc knockout mice

by Kavaljit H. Chhabra, Donald A. Morgan, Benjamin P. Tooke, Jessica M. Adams, Kamal Rahmouni, Malcolm J. Low
Published 2017-10-01

Ancient exaptation of a CORE-SINE retroposon into a highly conserved mammalian neuronal enhancer of the proopiomelanocortin gene.

by Andrea M Santangelo, Flávio S J de Souza, Lucía F Franchini, Viviana F Bumaschny, Malcolm J Low, Marcelo Rubinstein
Published 2007-10-01

Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity

by Kavaljit H. Chhabra, Jessica M. Adams, Graham L. Jones, Miho Yamashita, Martin Schlapschy, Arne Skerra, Marcelo Rubinstein, Malcolm J. Low
Published 2016-10-01

Electrical stimulation of renal nerves for modulating urine glucose excretion in rats

by Ahmad A. Jiman, Kavaljit H. Chhabra, Alfor G. Lewis, Paul S. Cederna, Randy J. Seeley, Malcolm J. Low, Tim M. Bruns
Published 2018-05-01

Not All Mice Are the Same: Standardization of Animal Research Data Presentation

by M. Bishr Omary, David E. Cohen, Emad M. El-Omar, Rajiv Jalan, Malcolm J. Low, Michael H. Nathanson, Richard M. Peek, Jr., Jerrold R. Turner
Published 2016-07-01

Hypothalamic POMC or MC4R deficiency impairs counterregulatory responses to hypoglycemia in mice

by Benjamin P. Tooke, Hui Yu, Jessica M. Adams, Graham L. Jones, Talisha Sutton-Kennedy, Lakshmi Mundada, Nathan R. Qi, Malcolm J. Low, Kavaljit H. Chhabra
Published 2019-02-01

Partially redundant enhancers cooperatively maintain Mammalian pomc expression above a critical functional threshold.

by Daniel D Lam, Flavio S J de Souza, Sofia Nasif, Miho Yamashita, Rodrigo López-Leal, Veronica Otero-Corchon, Kana Meece, Harini Sampath, Aaron J Mercer, Sharon L Wardlaw, Marcelo Rubinstein, Malcolm J Low
Published 2015-02-01

Lorcaserin improves glycemic control via a melanocortin neurocircuit

by Luke K. Burke, Emmanuel Ogunnowo-Bada, Teodora Georgescu, Claudia Cristiano, Pablo B. Martinez de Morentin, Lourdes Valencia Torres, Giuseppe D'Agostino, Christine Riches, Nicholas Heeley, Yue Ruan, Marcelo Rubinstein, Malcolm J. Low, Martin G. Myers, Justin J. Rochford, Mark L. Evans, Lora K. Heisler
Published 2017-10-01

Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons

by Luke K. Burke, Barbora Doslikova, Giuseppe D'Agostino, Megan Greenwald-Yarnell, Teodora Georgescu, Raffaella Chianese, Pablo B. Martinez de Morentin, Emmanuel Ogunnowo-Bada, Celine Cansell, Lourdes Valencia-Torres, Alastair S. Garfield, John Apergis-Schoute, Daniel D. Lam, John R. Speakman, Marcelo Rubinstein, Malcolm J. Low, Justin J. Rochford, Martin G. Myers, Mark L. Evans, Lora K. Heisler
Published 2016-03-01