Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies

by M. Catarina Silva, Stephen J. Haggarty
Published 2020-11-01

Neuronal reprograming of protein homeostasis by calcium-dependent regulation of the heat shock response.

by M Catarina Silva, Margarida D Amaral, Richard I Morimoto
Published 2013-08-01

A genetic screening strategy identifies novel regulators of the proteostasis network.

by M Catarina Silva, Susan Fox, Monica Beam, Happy Thakkar, Margarida D Amaral, Richard I Morimoto
Published 2011-12-01

Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons

by M. Catarina Silva, Ghata A. Nandi, Sharon Tentarelli, Ian K. Gurrell, Tanguy Jamier, Diane Lucente, Bradford C. Dickerson, Dean G. Brown, Nicholas J. Brandon, Stephen J. Haggarty
Published 2020-06-01

Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models

by M Catarina Silva, Fleur M Ferguson, Quan Cai, Katherine A Donovan, Ghata Nandi, Debasis Patnaik, Tinghu Zhang, Hai-Tsang Huang, Diane E Lucente, Bradford C Dickerson, Timothy J Mitchison, Eric S Fischer, Nathanael S Gray, Stephen J Haggarty
Published 2019-03-01

Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability

by M. Catarina Silva, Chialin Cheng, Waltraud Mair, Sandra Almeida, Helen Fong, M. Helal U. Biswas, Zhijun Zhang, Yadong Huang, Sally Temple, Giovanni Coppola, Daniel H. Geschwind, Anna Karydas, Bruce L. Miller, Kenneth S. Kosik, Fen-Biao Gao, Judith A. Steen, Stephen J. Haggarty
Published 2016-09-01

High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy

by Chialin Cheng, Surya A. Reis, Emily T. Adams, Daniel M. Fass, Steven P. Angus, Timothy J. Stuhlmiller, Jared Richardson, Hailey Olafson, Eric T. Wang, Debasis Patnaik, Roberta L. Beauchamp, Danielle A. Feldman, M. Catarina Silva, Mriganka Sur, Gary L. Johnson, Vijaya Ramesh, Bruce L. Miller, Sally Temple, Kenneth S. Kosik, Bradford C. Dickerson, Stephen J. Haggarty
Published 2021-08-01

A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies

by Celeste M. Karch, Aimee W. Kao, Anna Karydas, Khadijah Onanuga, Rita Martinez, Andrea Argouarch, Chao Wang, Cindy Huang, Peter Dongmin Sohn, Kathryn R. Bowles, Salvatore Spina, M. Catarina Silva, Jacob A. Marsh, Simon Hsu, Derian A. Pugh, Nupur Ghoshal, Joanne Norton, Yadong Huang, Suzee E. Lee, William W. Seeley, Panagiotis Theofilas, Lea T. Grinberg, Fermin Moreno, Kathryn McIlroy, Bradley F. Boeve, Nigel J. Cairns, John F. Crary, Stephen J. Haggarty, Justin K. Ichida, Kenneth S. Kosik, Bruce L. Miller, Li Gan, Alison M. Goate, Sally Temple, Carolina Alquezar, Kathryn Bowles, David Butler, John F. Crary, Li Gan, Alison M. Goate, Stephen J. Haggarty, Israel Hernandez, Valerie Hennes, Cindy Huang, Justin K. Ichida, Martin Kampmann, Aimee W. Kao, Celeste M. Karch, Anna Karydas, Kenneth S. Kosik, Rita Martinez, Khadijah Onanuga, M. Catarina Silva, Sally Temple, Chao Wang
Published 2019-11-01