A Metabolic Roadblock in Inflammatory Macrophages

by Luke A.J. O’Neill
Published 2016-10-01

Rocking the world of innate immunity: an interview with Luke O'Neill

by Luke A. J. O'Neill
Published 2018-12-01

Can NLRP3 inhibitors improve on dexamethasone for the treatment of COVID-19?

by Alexander Hooftman, Luke A.J. O'Neill
Published 2021-01-01

Correction: The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes

by Rebecca C. Coll, Luke A. J. O'Neill
Published 2013-01-01

Correction: The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes

by Rebecca C. Coll, Luke A. J. O'Neill
Published 2013-01-01

Correction: The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes.

by Rebecca C. Coll, Luke A. J. O'Neill
Published 2013-01-01

A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation

by Niamh C. Williams, Luke A. J. O’Neill
Published 2018-02-01

Correction: The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes.

by Rebecca C. Coll, Luke A. J. O'Neill
Published 2013-01-01

Metabolic reprogramming in macrophage polarization

by Silvia eGalván-Peña, Luke A.J. O'Neill
Published 2014-09-01

The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes.

by Rebecca C Coll, Avril Robertson, Mark Butler, Matthew Cooper, Luke A J O'Neill
Published 2011-01-01

Bruton's tyrosine kinase mediates the synergistic signalling between TLR9 and the B cell receptor by regulating calcium and calmodulin.

by Elaine F Kenny, Susan R Quinn, Sarah L Doyle, Paul M Vink, Hans van Eenennaam, Luke A J O'Neill
Published 2013-01-01

MicroRNA-21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection

by Daniel G. W. Johnston, Daniel G. W. Johnston, Jay Kearney, Zbigniew Zasłona, Michelle A. Williams, Luke A. J. O'Neill, Sinéad C. Corr
Published 2017-05-01

Both TLR2 and TRIF contribute to interferon-β production during Listeria infection.

by Camille Aubry, Sinéad C Corr, Sebastian Wienerroither, Céline Goulard, Ruth Jones, Amanda M Jamieson, Thomas Decker, Luke A J O'Neill, Olivier Dussurget, Pascale Cossart
Published 2012-01-01

A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins.

by Ricardo Núñez Miguel, Joyce Wong, Julian F Westoll, Heather J Brooks, Luke A J O'Neill, Nicholas J Gay, Clare E Bryant, Tom P Monie
Published 2007-08-01

Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease

by Caroline E. Sutton, Conor M. Finlay, Mathilde Raverdeau, James O. Early, Joseph DeCourcey, Zbigniew Zaslona, Luke A. J. O’Neill, Kingston H. G. Mills, Annie M. Curtis
Published 2017-12-01

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy

by Eunice E. To, Ross Vlahos, Raymond Luong, Michelle L. Halls, Patrick C. Reading, Paul T. King, Christopher Chan, Grant R. Drummond, Christopher G. Sobey, Brad R. S. Broughton, Malcolm R. Starkey, Renee van der Sluis, Sharon R. Lewin, Steven Bozinovski, Luke A. J. O’Neill, Tim Quach, Christopher J. H. Porter, Doug A. Brooks, John J. O’Leary, Stavros Selemidis
Published 2017-07-01

Caspase-11 promotes allergic airway inflammation

by Zbigniew Zasłona, Ewelina Flis, Mieszko M. Wilk, Richard G. Carroll, Eva M. Palsson-McDermott, Mark M. Hughes, Ciana Diskin, Kathy Banahan, Dylan G. Ryan, Alexander Hooftman, Alicja Misiak, Jay Kearney, Gunter Lochnit, Wilhelm Bertrams, Timm Greulich, Bernd Schmeck, Oliver J. McElvaney, Kingston H. G. Mills, Ed C. Lavelle, Małgorzata Wygrecka, Emma M. Creagh, Luke A. J. O’Neill
Published 2020-02-01

Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation

by Mark M. Hughes, Alexander Hooftman, Stefano Angiari, Padmaja Tummala, Zbigniew Zaslona, Marah C. Runtsch, Anne F. McGettrick, Caroline E. Sutton, Ciana Diskin, Melissa Rooke, Shuhei Takahashi, Srinivasan Sundararaj, Marco G. Casarotto, Jane E. Dahlstrom, Eva M. Palsson-McDermott, Sinead C. Corr, Kingston H.G. Mills, Roger J.S. Preston, Nouri Neamati, Yiyue Xie, Jonathan B. Baell, Philip G. Board, Luke A.J. O’Neill
Published 2019-10-01

The MyD88+ phenotype is an adverse prognostic factor in epithelial ovarian cancer.

by Charles J d'Adhemar, Cathy D Spillane, Michael F Gallagher, Mark Bates, Katie M Costello, Jacqui Barry-O'Crowley, Kathryn Haley, Niamh Kernan, Ciara Murphy, Paul C Smyth, Ken O'Byrne, Stephen Pennington, Aoife A Cooke, Brendan Ffrench, Cara M Martin, Dearbhaile O'Donnell, Bryan Hennessy, Britta Stordal, Stephen Finn, Amanda McCann, Noreen Gleeson, Tom D'Arcy, Brian Flood, Luke A J O'Neill, Orla Sheils, Sharon O'Toole, John J O'Leary
Published 2014-01-01