Similarity between mutation spectra in hypermutated genomes of rubella virus and in SARS-CoV-2 genomes accumulated during the COVID-19 pandemic.

by Leszek J Klimczak, Thomas A Randall, Natalie Saini, Jian-Liang Li, Dmitry A Gordenin
Published 2020-01-01

Similarity between mutation spectra in hypermutated genomes of rubella virus and in SARS-CoV-2 genomes accumulated during the COVID-19 pandemic

by Leszek J. Klimczak, Thomas A. Randall, Natalie Saini, Jian-Liang Li, Dmitry A. Gordenin, Sebastian D. Fugmann
Published 2020-01-01

APOBEC-Induced Cancer Mutations Are Uniquely Enriched in Early-Replicating, Gene-Dense, and Active Chromatin Regions

by Marat D. Kazanov, Steven A. Roberts, Paz Polak, John Stamatoyannopoulos, Leszek J. Klimczak, Dmitry A. Gordenin, Shamil R. Sunyaev
Published 2015-11-01

Mutational signatures of redox stress in yeast single-strand DNA and of aging in human mitochondrial DNA share a common feature.

by Natalya P Degtyareva, Natalie Saini, Joan F Sterling, Victoria C Placentra, Leszek J Klimczak, Dmitry A Gordenin, Paul W Doetsch
Published 2019-05-01

Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation.

by Cynthia J Sakofsky, Natalie Saini, Leszek J Klimczak, Kin Chan, Ewa P Malc, Piotr A Mieczkowski, Adam B Burkholder, David Fargo, Dmitry A Gordenin
Published 2019-09-01

Correction: Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation.

by Cynthia J Sakofsky, Natalie Saini, Leszek J Klimczak, Kin Chan, Ewa P Malc, Piotr A Mieczkowski, Adam B Burkholder, David Fargo, Dmitry A Gordenin
Published 2020-03-01

UV-exposure, endogenous DNA damage, and DNA replication errors shape the spectra of genome changes in human skin.

by Natalie Saini, Camille K Giacobone, Leszek J Klimczak, Brian N Papas, Adam B Burkholder, Jian-Liang Li, David C Fargo, Re Bai, Kevin Gerrish, Cynthia L Innes, Shepherd H Schurman, Dmitry A Gordenin
Published 2021-01-01

Infectious vaccine-derived rubella viruses emerge, persist, and evolve in cutaneous granulomas of children with primary immunodeficiencies.

by Ludmila Perelygina, Min-Hsin Chen, Suganthi Suppiah, Adebola Adebayo, Emily Abernathy, Morna Dorsey, Lionel Bercovitch, Kenneth Paris, Kevin P White, Alfons Krol, Julie Dhossche, Ivan Y Torshin, Natalie Saini, Leszek J Klimczak, Dmitry A Gordenin, Andrey Zharkikh, Stanley Plotkin, Kathleen E Sullivan, Joseph Icenogle
Published 2019-10-01

The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts.

by Natalie Saini, Steven A Roberts, Leszek J Klimczak, Kin Chan, Sara A Grimm, Shuangshuang Dai, David C Fargo, Jayne C Boyer, William K Kaufmann, Jack A Taylor, Eunjung Lee, Isidro Cortes-Ciriano, Peter J Park, Shepherd H Schurman, Ewa P Malc, Piotr A Mieczkowski, Dmitry A Gordenin
Published 2016-10-01