Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling

by Eva d’Hennezel, Sahar Abubucker, Leon O. Murphy, Thomas W. Cullen, Catherine Lozupone
Published 2017-11-01

Atg4b-dependent autophagic flux alleviates Huntington's disease progression.

by Catia C Proenca, Natacha Stoehr, Mario Bernhard, Shanon Seger, Christel Genoud, Ana Roscic, Paolo Paganetti, Shanming Liu, Leon O Murphy, Rainer Kuhn, Tewis Bouwmeester, Ivan Galimberti
Published 2013-01-01

Autophagy-Independent Lysosomal Targeting Regulated by ULK1/2-FIP200 and ATG9

by Jonathan M. Goodwin, William E. Dowdle, Rowena DeJesus, Zuncai Wang, Philip Bergman, Marek Kobylarz, Alicia Lindeman, Ramnik J. Xavier, Gregory McAllister, Beat Nyfeler, Gregory Hoffman, Leon O. Murphy
Published 2017-09-01

RAD001 enhances the potency of BEZ235 to inhibit mTOR signaling and tumor growth.

by Beat Nyfeler, Yan Chen, Xiaoyan Li, Maria Pinzon-Ortiz, Zuncai Wang, Anupama Reddy, Elina Pradhan, Rita Das, Joseph Lehár, Robert Schlegel, Peter M Finan, Z Alexander Cao, Leon O Murphy, Alan Huang
Published 2012-01-01

An iron-dependent metabolic vulnerability underlies VPS34-dependence in RKO cancer cells.

by Marek J Kobylarz, Jonathan M Goodwin, Zhao B Kang, John W Annand, Sarah Hevi, Ellen O'Mahony, Gregory McAllister, John Reece-Hoyes, Qiong Wang, John Alford, Carsten Russ, Alicia Lindeman, Martin Beibel, Guglielmo Roma, Walter Carbone, Judith Knehr, Joseph Loureiro, Christophe Antczak, Dmitri Wiederschain, Leon O Murphy, Suchithra Menon, Beat Nyfeler
Published 2020-01-01

Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62

by Rowena DeJesus, Francesca Moretti, Gregory McAllister, Zuncai Wang, Phil Bergman, Shanming Liu, Elizabeth Frias, John Alford, John S Reece-Hoyes, Alicia Lindeman, Jennifer Kelliher, Carsten Russ, Judith Knehr, Walter Carbone, Martin Beibel, Guglielmo Roma, Aylwin Ng, John A Tallarico, Jeffery A Porter, Ramnik J Xavier, Craig Mickanin, Leon O Murphy, Gregory R Hoffman, Beat Nyfeler
Published 2016-06-01

Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

by Benoit Bilanges, Samira Alliouachene, Wayne Pearce, Daniele Morelli, Gyorgy Szabadkai, Yuen-Li Chung, Gaëtan Chicanne, Colin Valet, Julia M. Hill, Peter J. Voshol, Lucy Collinson, Christopher Peddie, Khaled Ali, Essam Ghazaly, Vinothini Rajeeve, Georgios Trichas, Shankar Srinivas, Claire Chaussade, Rachel S. Salamon, Jonathan M. Backer, Cheryl L. Scudamore, Maria A. Whitehead, Erin P. Keaney, Leon O. Murphy, Robert K. Semple, Bernard Payrastre, Sharon A. Tooze, Bart Vanhaesebroeck
Published 2017-11-01

Identification of elongation factor G as the conserved cellular target of argyrin B.

by Beat Nyfeler, Dominic Hoepfner, Deborah Palestrant, Christina A Kirby, Lewis Whitehead, Robert Yu, Gejing Deng, Ruth E Caughlan, Angela L Woods, Adriana K Jones, S Whitney Barnes, John R Walker, Swann Gaulis, Ervan Hauy, Saskia M Brachmann, Philipp Krastel, Christian Studer, Ralph Riedl, David Estoppey, Thomas Aust, N Rao Movva, Zuncai Wang, Michael Salcius, Gregory A Michaud, Gregory McAllister, Leon O Murphy, John A Tallarico, Christopher J Wilson, Charles R Dean
Published 2012-01-01