ErbB2 and NFκB overexpression as predictors of chemoradiation resistance and putative targets to overcome resistance in muscle-invasive bladder cancer.

by Fumitaka Koga, Soichiro Yoshida, Manabu Tatokoro, Satoru Kawakami, Yasuhisa Fujii, Jiro Kumagai, Len Neckers, Kazunori Kihara
Published 2011-01-01

Mitochondrial topoisomerase I is critical for mitochondrial integrity and cellular energy metabolism.

by Céline Douarre, Carole Sourbier, Ilaria Dalla Rosa, Benu Brata Das, Christophe E Redon, Hongliang Zhang, Len Neckers, Yves Pommier
Published 2012-01-01

Targeting heat shock protein 90 for the treatment of malignant pheochromocytoma.

by Alessio Giubellino, Carole Sourbier, Min-Jung Lee, Brad Scroggins, Petra Bullova, Michael Landau, Weiwen Ying, Len Neckers, Jane B Trepel, Karel Pacak
Published 2013-01-01

Proteomic analysis of proteome and histone post-translational modifications in heat shock protein 90 inhibition-mediated bladder cancer therapeutics

by Qingdi Quentin Li, Jian-Jiang Hao, Zheng Zhang, L. Spencer Krane, Kai H. Hammerich, Thomas Sanford, Jane B. Trepel, Len Neckers, Piyush K. Agarwal
Published 2017-03-01

Phosphorylation induced cochaperone unfolding promotes kinase recruitment and client class-specific Hsp90 phosphorylation

by Ashleigh B. Bachman, Dimitra Keramisanou, Wanping Xu, Kristin Beebe, Michael A. Moses, M. V. Vasantha Kumar, Geoffrey Gray, Radwan Ebna Noor, Arjan van der Vaart, Len Neckers, Ioannis Gelis
Published 2018-01-01

Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants.

by Thomas L Prince, Toshiki Kijima, Manabu Tatokoro, Sunmin Lee, Shinji Tsutsumi, Kendrick Yim, Candy Rivas, Sylvia Alarcon, Harvey Schwartz, Kofi Khamit-Kush, Bradley T Scroggins, Kristin Beebe, Jane B Trepel, Len Neckers
Published 2015-01-01

HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation

by Toshiki Kijima, Thomas L. Prince, Megan L. Tigue, Kendrick H. Yim, Harvey Schwartz, Kristin Beebe, Sunmin Lee, Marek A. Budzynski, Heinric Williams, Jane B. Trepel, Lea Sistonen, Stuart Calderwood, Len Neckers
Published 2018-05-01

Hsp90 middle domain phosphorylation initiates a complex conformational program to recruit the ATPase-stimulating cochaperone Aha1

by Wanping Xu, Kristin Beebe, Juan D. Chavez, Marta Boysen, YinYing Lu, Abbey D. Zuehlke, Dimitra Keramisanou, Jane B. Trepel, Christosomos Prodromou, Matthias P. Mayer, James E. Bruce, Ioannis Gelis, Len Neckers
Published 2019-06-01

The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis

by Abhinav Joshi, Li Dai, Yanxin Liu, Jungsoon Lee, Nastaran Mohammadi Ghahhari, Gregory Segala, Kristin Beebe, Lisa M. Jenkins, Gaelyn C. Lyons, Lilia Bernasconi, Francis T. F. Tsai, David A. Agard, Len Neckers, Didier Picard
Published 2020-01-01

An Hsp90 co-chaperone protein in yeast is functionally replaced by site-specific posttranslational modification in humans

by Abbey D. Zuehlke, Michael Reidy, Coney Lin, Paul LaPointe, Sarah Alsomairy, D. Joshua Lee, Genesis M. Rivera-Marquez, Kristin Beebe, Thomas Prince, Sunmin Lee, Jane B. Trepel, Wanping Xu, Jill Johnson, Daniel Masison, Len Neckers
Published 2017-05-01

Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target.

by Mariëlle I Gallegos Ruiz, Karijn Floor, Paul Roepman, José A Rodriguez, Gerrit A Meijer, Wolter J Mooi, Ewa Jassem, Jacek Niklinski, Thomas Muley, Nico van Zandwijk, Egbert F Smit, Kristin Beebe, Len Neckers, Bauke Ylstra, Giuseppe Giaccone
Published 2008-03-01

Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors

by Mark R. Woodford, Andrew W. Truman, Diana M. Dunn, Sandra M. Jensen, Richard Cotran, Renee Bullard, Mourad Abouelleil, Kristin Beebe, Donald Wolfgeher, Sara Wierzbicki, Dawn E. Post, Tiffany Caza, Shinji Tsutsumi, Barry Panaretou, Stephen J. Kron, Jane B. Trepel, Steve Landas, Chrisostomos Prodromou, Oleg Shapiro, William G. Stetler-Stevenson, Dimitra Bourboulia, Len Neckers, Gennady Bratslavsky, Mehdi Mollapour
Published 2016-02-01

c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells

by Diana M. Dunn, Mark R. Woodford, Andrew W. Truman, Sandra M. Jensen, Jacqualyn Schulman, Tiffany Caza, Taylor C. Remillard, David Loiselle, Donald Wolfgeher, Brian S.J. Blagg, Lucas Franco, Timothy A. Haystead, Soumya Daturpalli, Matthias P. Mayer, Jane B. Trepel, Rhodri M.L. Morgan, Chrisostomos Prodromou, Stephen J. Kron, Barry Panaretou, William G. Stetler-Stevenson, Steve K. Landas, Len Neckers, Gennady Bratslavsky, Dimitra Bourboulia, Mehdi Mollapour
Published 2015-08-01