The disruption of protein−protein interactions with co-chaperones and client substrates as a strategy towards Hsp90 inhibition

by Michael A. Serwetnyk, Brian S.J. Blagg
Published 2021-06-01

Induction of Heat Shock Protein 70 (Hsp70) prevents Neuregulin-Induced Demyelination by Enhancing the Proteasomal Clearance of c-Jun

by Chengyuan Li, Jiacheng Ma, Huiping Zhao, Brian S.J Blagg, Rick T Dobrowsky
Published 2012-11-01

High-Throughput Screen of Natural Product Libraries for Hsp90 Inhibitors

by Jason Davenport, Maurie Balch, Lakshmi Galam, Antwan Girgis, Jessica Hall, Brian S. J. Blagg, Robert L. Matts
Published 2014-02-01

The Alpha Isoform of Heat Shock Protein 90 and the Co-chaperones p23 and Cdc37 Promote Opioid Anti-nociception in the Brain

by Wei Lei, Wei Lei, David I. Duron, Carrie Stine, Sanket Mishra, Brian S. J. Blagg, John M. Streicher
Published 2019-11-01

Discovery of Novel Hsp90 C-Terminal Inhibitors Using 3D-Pharmacophores Derived from Molecular Dynamics Simulations

by Tihomir Tomašič, Martina Durcik, Bradley M. Keegan, Darja Gramec Skledar, Živa Zajec, Brian S. J. Blagg, Sharon D. Bryant
Published 2020-09-01

Novel C‐terminal heat shock protein 90 inhibitors target breast cancer stem cells and block migration, self‐renewal, and epithelial–mesenchymal transition

by Chitra Subramanian, Patrick T. Grogan, Ton Wang, Joseph Bazzill, Ang Zuo, Peter T. White, Avinaash Kalidindi, Dawn Kuszynski, Grace Wang, Brian S. J. Blagg, Mark S. Cohen
Published 2020-09-01

Inhibiting Heat-Shock Protein 90 Reverses Sensory Hypoalgesia in Diabetic Mice

by Michael J Urban, Chengyuan Li, Cuijuan Yu, Yuanming Lu, Joanna M Krise, Michelle P McIntosh, Roger A Rajewski, Brian S J Blagg, Rick T Dobrowsky
Published 2010-07-01

Structure-guided design of an Hsp90β N-terminal isoform-selective inhibitor

by Anuj Khandelwal, Caitlin N. Kent, Maurie Balch, Shuxia Peng, Sanket J. Mishra, Junpeng Deng, Victor W. Day, Weiya Liu, Chitra Subramanian, Mark Cohen, Jeffery M. Holzbeierlein, Robert Matts, Brian S. J. Blagg
Published 2018-01-01

c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells

by Diana M. Dunn, Mark R. Woodford, Andrew W. Truman, Sandra M. Jensen, Jacqualyn Schulman, Tiffany Caza, Taylor C. Remillard, David Loiselle, Donald Wolfgeher, Brian S.J. Blagg, Lucas Franco, Timothy A. Haystead, Soumya Daturpalli, Matthias P. Mayer, Jane B. Trepel, Rhodri M.L. Morgan, Chrisostomos Prodromou, Stephen J. Kron, Barry Panaretou, William G. Stetler-Stevenson, Steve K. Landas, Len Neckers, Gennady Bratslavsky, Dimitra Bourboulia, Mehdi Mollapour
Published 2015-08-01