A new Python library to analyse skeleton images confirms malaria parasite remodelling of the red blood cell membrane skeleton

by Juan Nunez-Iglesias, Adam J. Blanch, Oliver Looker, Matthew W. Dixon, Leann Tilley
Published 2018-02-01

Biochemical and cellular characterisation of the Plasmodium falciparum M1 alanyl aminopeptidase (PfM1AAP) and M17 leucyl aminopeptidase (PfM17LAP)

by Rency Mathew, Juliane Wunderlich, Karine Thivierge, Krystyna Cwiklinski, Claire Dumont, Leann Tilley, Petra Rohrbach, John P. Dalton
Published 2021-02-01

The apical complex provides a regulated gateway for secretion of invasion factors in Toxoplasma.

by Nicholas J Katris, Giel G van Dooren, Paul J McMillan, Eric Hanssen, Leann Tilley, Ross F Waller
Published 2014-04-01

The knob protein KAHRP assembles into a ring-shaped structure that underpins virulence complex assembly.

by Oliver Looker, Adam J Blanch, Boyin Liu, Juan Nunez-Iglesias, Paul J McMillan, Leann Tilley, Matthew W A Dixon
Published 2019-05-01

Ankyrin-1 Gene Exhibits Allelic Heterogeneity in Conferring Protection Against Malaria

by Hong Ming Huang, Denis C. Bauer, Patrick M. Lelliott, Matthew W. A. Dixon, Leann Tilley, Brendan J. McMorran, Simon J. Foote, Gaetan Burgio
Published 2017-09-01

Contrasting Inducible Knockdown of the Auxiliary PTEX Component PTEX88 in P. falciparum and P. berghei Unmasks a Role in Parasite Virulence.

by Scott A Chisholm, Emma McHugh, Rachel Lundie, Matthew W A Dixon, Sreejoyee Ghosh, Meredith O'Keefe, Leann Tilley, Ming Kalanon, Tania F de Koning-Ward
Published 2016-01-01

Non‐canonical metabolic pathways in the malaria parasite detected by isotope‐tracing metabolomics

by Simon A Cobbold, Madel V Tutor, Philip Frasse, Emma McHugh, Markus Karnthaler, Darren J Creek, Audrey Odom John, Leann Tilley, Stuart A Ralph, Malcolm J McConville
Published 2021-04-01

Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking.

by Kit Kennedy, Simon A Cobbold, Eric Hanssen, Jakob Birnbaum, Natalie J Spillman, Emma McHugh, Hannah Brown, Leann Tilley, Tobias Spielmann, Malcolm J McConville, Stuart A Ralph
Published 2019-07-01

Essential role of Plasmodium perforin-like protein 4 in ookinete midgut passage.

by Elena Deligianni, Natalie C Silmon de Monerri, Paul J McMillan, Lucia Bertuccini, Fabiana Superti, Maria Manola, Lefteris Spanos, Christos Louis, Michael J Blackman, Leann Tilley, Inga Siden-Kiamos
Published 2018-01-01

Correction: Essential role of Plasmodium perforin-like protein 4 in ookinete midgut passage.

by Elena Deligianni, Natalie C Silmon de Monerri, Paul J McMillan, Lucia Bertuccini, Fabiana Superti, Maria Manola, Lefteris Spanos, Christos Louis, Michael J Blackman, Leann Tilley, Inga Siden-Kiamos
Published 2018-01-01

Disrupting assembly of the inner membrane complex blocks Plasmodium falciparum sexual stage development.

by Molly Parkyn Schneider, Boyin Liu, Philipp Glock, Annika Suttie, Emma McHugh, Dean Andrew, Steven Batinovic, Nicholas Williamson, Eric Hanssen, Paul McMillan, Marion Hliscs, Leann Tilley, Matthew W A Dixon
Published 2017-10-01

The Metabolite Repair Enzyme Phosphoglycolate Phosphatase Regulates Central Carbon Metabolism and Fosmidomycin Sensitivity in Plasmodium falciparum

by Laure Dumont, Mark B. Richardson, Phillip van der Peet, Danushka S. Marapana, Tony Triglia, Matthew W. A. Dixon, Alan F. Cowman, Spencer J. Williams, Leann Tilley, Malcolm J. McConville, Simon A. Cobbold
Published 2019-12-01

Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome

by Jessica L. Bridgford, Stanley C. Xie, Simon A. Cobbold, Charisse Flerida A. Pasaje, Susann Herrmann, Tuo Yang, David L. Gillett, Lawrence R. Dick, Stuart A. Ralph, Con Dogovski, Natalie J. Spillman, Leann Tilley
Published 2018-09-01

Role of Plasmodium falciparum Protein GEXP07 in Maurer’s Cleft Morphology, Knob Architecture, and P. falciparum EMP1 Trafficking

by Emma McHugh, Olivia M. S. Carmo, Adam Blanch, Oliver Looker, Boyin Liu, Snigdha Tiash, Dean Andrew, Steven Batinovic, Andy J. Y. Low, Hyun-Jung Cho, Paul McMillan, Leann Tilley, Matthew W. A. Dixon
Published 2020-03-01

An exported protein-interacting complex involved in the trafficking of virulence determinants in Plasmodium-infected erythrocytes

by Steven Batinovic, Emma McHugh, Scott A. Chisholm, Kathryn Matthews, Boiyin Liu, Laure Dumont, Sarah C. Charnaud, Molly Parkyn Schneider, Paul R. Gilson, Tania F. de Koning-Ward, Matthew W. A. Dixon, Leann Tilley
Published 2017-07-01

A thiol probe for measuring unfolded protein load and proteostasis in cells

by Moore Z. Chen, Nagaraj S. Moily, Jessica L. Bridgford, Rebecca J. Wood, Mona Radwan, Trevor A. Smith, Zhegang Song, Ben Zhong Tang, Leann Tilley, Xiaohong Xu, Gavin E. Reid, Mahmoud A. Pouladi, Yuning Hong, Danny M. Hatters
Published 2017-09-01

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance

by Tuo Yang, Lee M. Yeoh, Madel V. Tutor, Matthew W. Dixon, Paul J. McMillan, Stanley C. Xie, Jessica L. Bridgford, David L. Gillett, Michael F. Duffy, Stuart A. Ralph, Malcolm J. McConville, Leann Tilley, Simon A. Cobbold
Published 2019-11-01

Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance.

by Con Dogovski, Stanley C Xie, Gaetan Burgio, Jess Bridgford, Sachel Mok, James M McCaw, Kesinee Chotivanich, Shannon Kenny, Nina Gnädig, Judith Straimer, Zbynek Bozdech, David A Fidock, Julie A Simpson, Arjen M Dondorp, Simon Foote, Nectarios Klonis, Leann Tilley
Published 2015-04-01

The exported chaperone Hsp70-x supports virulence functions for Plasmodium falciparum blood stage parasites.

by Sarah C Charnaud, Matthew W A Dixon, Catherine Q Nie, Lia Chappell, Paul R Sanders, Thomas Nebl, Eric Hanssen, Matthew Berriman, Jo-Anne Chan, Adam J Blanch, James G Beeson, Julian C Rayner, Jude M Przyborski, Leann Tilley, Brendan S Crabb, Paul R Gilson
Published 2017-01-01