Distribution bias and biochemical characterization of TOP1MT single nucleotide variants

by Hongliang Zhang, Yeonee Seol, Keli Agama, Keir C. Neuman, Yves Pommier
Published 2017-08-01

Exploring DNA topoisomerase I ligand space in search of novel anticancer agents.

by Malgorzata N Drwal, Keli Agama, Laurence P G Wakelin, Yves Pommier, Renate Griffith
Published 2011-01-01

The antitumor activity of CYB-L10, a human topoisomerase IB catalytic inhibitor

by Qian Yu, Yu Chen, Hui Yang, Hong-Li Zhang, Keli Agama, Yves Pommier, Lin-Kun An
Published 2019-01-01

PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation

by Yilun Sun, Jiji Chen, Shar-yin N. Huang, Yijun P. Su, Wenjie Wang, Keli Agama, Sourav Saha, Lisa M. Jenkins, John M. Pascal, Yves Pommier
Published 2021-08-01

Collaborative action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repair.

by Kyoko Nakamura, Toshiaki Kogame, Hiroyuki Oshiumi, Akira Shinohara, Yoshiki Sumitomo, Keli Agama, Yves Pommier, Kimiko M Tsutsui, Ken Tsutsui, Edgar Hartsuiker, Tomoo Ogi, Shunichi Takeda, Yoshihito Taniguchi
Published 2010-01-01

ALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair.

by Masataka Tsuda, Kosai Cho, Masato Ooka, Naoto Shimizu, Reiko Watanabe, Akira Yasui, Yuka Nakazawa, Tomoo Ogi, Hiroshi Harada, Keli Agama, Jun Nakamura, Ryuta Asada, Haruna Fujiike, Tetsushi Sakuma, Takashi Yamamoto, Junko Murai, Masahiro Hiraoka, Kaoru Koike, Yves Pommier, Shunichi Takeda, Kouji Hirota
Published 2017-01-01