Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential

by Paula Martín Moyano, Václav Němec, Kamil Paruch
Published 2020-10-01

Chk1 Inhibitor SCH900776 Effectively Potentiates the Cytotoxic Effects of Platinum-Based Chemotherapeutic Drugs in Human Colon Cancer Cells

by Jarmila Herůdková, Kamil Paruch, Prashant Khirsariya, Karel Souček, Martin Krkoška, Olga Vondálová Blanářová, Petr Sova, Alois Kozubík, Alena Hyršlová Vaculová
Published 2017-10-01

BRCA1 or CDK12 loss sensitizes cells to CHK1 inhibitors

by Hana Paculová, Juraj Kramara, Šárka Šimečková, Radek Fedr, Karel Souček, Ondřej Hylse, Kamil Paruch, Marek Svoboda, Martin Mistrík, Jiří Kohoutek
Published 2017-10-01

The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel‐resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe

by Stanislav Drápela, Prashant Khirsariya, Wytske M. vanWeerden, Radek Fedr, Tereza Suchánková, Diana Búzová, Jan Červený, Aleš Hampl, Martin Puhr, William R. Watson, Zoran Culig, Lumír Krejčí, Kamil Paruch, Karel Souček
Published 2020-10-01