Dengue Virus Non-Structural Protein 5

by Abbas El Sahili, Julien Lescar
Published 2017-04-01

Substrate Channel Flexibility in Pseudomonas aeruginosa MurB Accommodates Two Distinct Substrates.

by Ming Wei Chen, Bernhard Lohkamp, Robert Schnell, Julien Lescar, Gunter Schneider
Published 2013-01-01

Structure of a diguanylate cyclase from Thermotoga maritima: insights into activation, feedback inhibition and thermostability.

by Angeline Deepthi, Chong Wai Liew, Zhao-Xun Liang, Kunchithapadam Swaminathan, Julien Lescar
Published 2014-01-01

Crystal structure of the dengue virus methyltransferase bound to a 5'-capped octameric RNA.

by Li Jian Yap, Dahai Luo, Ka Yan Chung, Siew Pheng Lim, Christophe Bodenreider, Christian Noble, Pei-Yong Shi, Julien Lescar
Published 2010-09-01

The protein kinase CK2 catalytic domain from Plasmodium falciparum: crystal structure, tyrosine kinase activity and inhibition

by David Ruiz-Carrillo, Jianqing Lin, Abbas El Sahili, Meng Wei, Siu Kwan Sze, Peter C. F. Cheung, Christian Doerig, Julien Lescar
Published 2018-05-01

The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes.

by François Ferron, Zongli Li, Eric I Danek, Dahai Luo, Yeehwa Wong, Bruno Coutard, Violaine Lantez, Rémi Charrel, Bruno Canard, Thomas Walz, Julien Lescar
Published 2011-05-01

Antibodies targeting the PfRH1 binding domain inhibit invasion of Plasmodium falciparum merozoites.

by Xiaohong Gao, Kim Pin Yeo, Siqi Sharon Aw, Claudia Kuss, Jayasree K Iyer, Saraswathy Genesan, Ravikumar Rajamanonmani, Julien Lescar, Zbynek Bozdech, Peter R Preiser
Published 2008-07-01

Structure of the NS2B-NS3 protease from Zika virus after self-cleavage

by Wint Wint Phoo, Yan Li, Zhenzhen Zhang, Michelle Yueqi Lee, Ying Ru Loh, Yaw Bia Tan, Elizabeth Yihui Ng, Julien Lescar, CongBao Kang, Dahai Luo
Published 2016-11-01

Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2'-O-methyltransferase nsp10/nsp16 complex.

by Etienne Decroly, Claire Debarnot, François Ferron, Mickael Bouvet, Bruno Coutard, Isabelle Imbert, Laure Gluais, Nicolas Papageorgiou, Andrew Sharff, Gérard Bricogne, Miguel Ortiz-Lombardia, Julien Lescar, Bruno Canard
Published 2011-05-01

The SiaABC threonine phosphorylation pathway controls biofilm formation in response to carbon availability in Pseudomonas aeruginosa.

by Wee-Han Poh, Jianqing Lin, Brendan Colley, Nicolai Müller, Boon Chong Goh, David Schleheck, Abbas El Sahili, Andreas Marquardt, Yang Liang, Staffan Kjelleberg, Julien Lescar, Scott A Rice, Janosch Klebensberger
Published 2020-01-01

SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets

by Palur V Raghuvamsi, Nikhil K Tulsian, Firdaus Samsudin, Xinlei Qian, Kiren Purushotorman, Gu Yue, Mary M Kozma, Wong Y Hwa, Julien Lescar, Peter J Bond, Paul A MacAry, Ganesh S Anand
Published 2021-02-01

Allosteric pyruvate kinase-based “logic gate” synergistically senses energy and sugar levels in Mycobacterium tuberculosis

by Wenhe Zhong, Liang Cui, Boon Chong Goh, Qixu Cai, Peiying Ho, Yok Hian Chionh, Meng Yuan, Abbas El Sahili, Linda A. Fothergill-Gilmore, Malcolm D. Walkinshaw, Julien Lescar, Peter C. Dedon
Published 2017-12-01

The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription.

by Benjamin Morin, Bruno Coutard, Michaela Lelke, François Ferron, Romy Kerber, Saïd Jamal, Antoine Frangeul, Cécile Baronti, Rémi Charrel, Xavier de Lamballerie, Clemens Vonrhein, Julien Lescar, Gérard Bricogne, Stephan Günther, Bruno Canard
Published 2010-09-01

The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production.

by Moon Y F Tay, Kate Smith, Ivan H W Ng, Kitti W K Chan, Yongqian Zhao, Eng Eong Ooi, Julien Lescar, Dahai Luo, David A Jans, Jade K Forwood, Subhash G Vasudevan
Published 2016-09-01

Plasmodium P36 determines host cell receptor usage during sporozoite invasion

by Giulia Manzoni, Carine Marinach, Selma Topçu, Sylvie Briquet, Morgane Grand, Matthieu Tolle, Marion Gransagne, Julien Lescar, Chiara Andolina, Jean-François Franetich, Mirjam B Zeisel, Thierry Huby, Eric Rubinstein, Georges Snounou, Dominique Mazier, François Nosten, Thomas F Baumert, Olivier Silvie
Published 2017-05-01

A crystal structure of the Dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication.

by Yongqian Zhao, Tingjin Sherryl Soh, Jie Zheng, Kitti Wing Ki Chan, Wint Wint Phoo, Chin Chin Lee, Moon Y F Tay, Kunchithapadam Swaminathan, Tobias C Cornvik, Siew Pheng Lim, Pei-Yong Shi, Julien Lescar, Subhash G Vasudevan, Dahai Luo
Published 2015-03-01

Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling.

by Siew Pheng Lim, Christian Guy Noble, Cheah Chen Seh, Tingjin Sherryl Soh, Abbas El Sahili, Grace Kar Yarn Chan, Julien Lescar, Rishi Arora, Timothy Benson, Shahul Nilar, Ujjini Manjunatha, Kah Fei Wan, Hongping Dong, Xuping Xie, Pei-Yong Shi, Fumiaki Yokokawa
Published 2016-08-01

Defining the structural basis for human leukocyte antigen reactivity in clinical transplantation

by Yue Gu, Robynne W. K. Koh, May Ling Lai, Denise Pochinco, Rachel Z. C. Teo, Marieta Chan, Tanusya M. Murali, Chong Wai Liew, Yee Hwa Wong, Nicholas R. J. Gascoigne, Kathryn J. Wood, Julien Lescar, Peter Nickerson, Paul A. MacAry, Anantharaman Vathsala
Published 2020-10-01

Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01

by Yue Gu, Yee Hwa Wong, Chong Wai Liew, Conrad E. Z. Chan, Tanusya M. Murali, Jiawei Yap, Chien Tei Too, Kiren Purushotorman, Maryam Hamidinia, Abbas El Sahili, Angeline T. H. Goh, Rachel Z. C. Teo, Kathryn J. Wood, Brendon J. Hanson, Nicholas R. J. Gascoigne, Julien Lescar, Anantharaman Vathsala, Paul A. MacAry
Published 2019-02-01