Functional genomics identifies predictive markers and clinically actionable resistance mechanisms to CDK4/6 inhibition in bladder cancer

by Zhichao Tong, Anuja Sathe, Benedikt Ebner, Pan Qi, Christian Veltkamp, Juergen E. Gschwend, Per Sonne Holm, Roman Nawroth
Published 2019-07-01

S6K1 and 4E-BP1 are independent regulated and control cellular growth in bladder cancer.

by Roman Nawroth, Florian Stellwagen, Wolfgang A Schulz, Robert Stoehr, Arndt Hartmann, Bernd J Krause, Juergen E Gschwend, Margitta Retz
Published 2011-01-01

Antagonistic Effects of Sodium Butyrate and N-(4-Hydroxyphenyl)-retinamide on Prostate Cancer

by Rainer Kuefer, Felicitas Genze, Waltraud Zugmaier, Richard E. Hautmann, Ludwig Rinnab, Juergen E. Gschwend, Marina Angelmeier, Aidee Estrada, Berthold Buechele
Published 2007-03-01

Parallel PI3K, AKT and mTOR inhibition is required to control feedback loops that limit tumor therapy.

by Anuja Sathe, Géraldine Chalaud, Immanuel Oppolzer, Kit Yeng Wong, Margarita von Busch, Sebastian C Schmid, Zhichao Tong, Margitta Retz, Juergen E Gschwend, Wolfgang A Schulz, Roman Nawroth
Published 2018-01-01

Genomic Profiling of Hormone-Naïve Lymph Node Metastases in Patients with Prostate Cancer

by Pamela L. Paris, Matthias D. Hofer, Giancarlo Albo, Rainer Kuefer, Juergen E. Gschwend, Richard E. Hautmann, Jane Fridyland, Jeffrey Simko, Peter R. Carroll, Mark A. Rubin, Colin Collins
Published 2006-12-01

STAT3/5 Inhibitors Suppress Proliferation in Bladder Cancer and Enhance Oncolytic Adenovirus Therapy

by Sruthi V. Hindupur, Sebastian C. Schmid, Jana Annika Koch, Ahmed Youssef, Eva-Maria Baur, Dongbiao Wang, Thomas Horn, Julia Slotta-Huspenina, Juergen E. Gschwend, Per Sonne Holm, Roman Nawroth
Published 2020-02-01