Active fragments from pro- and antiapoptotic BCL-2 proteins have distinct membrane behavior reflecting their functional divergence.

by Yannis Guillemin, Jonathan Lopez, Diana Gimenez, Gustavo Fuertes, Juan Garcia Valero, Loïc Blum, Philippe Gonzalo, Jesùs Salgado, Agnès Girard-Egrot, Abdel Aouacheria
Published 2010-01-01

µ-Calpain conversion of antiapoptotic Bfl-1 (BCL2A1) into a prodeath factor reveals two distinct alpha-helices inducing mitochondria-mediated apoptosis.

by Juan García Valero, Aurélie Cornut-Thibaut, Romain Jugé, Anne-Laure Debaud, Diana Giménez, Germain Gillet, Nathalie Bonnefoy-Bérard, Jesús Salgado, Gilles Salles, Abdel Aouacheria, Jérôme Kucharczak
Published 2012-01-01

Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity.

by Mar Orzáez, Mónica Sancho, Sandra Marchán, Laura Mondragón, Rebeca Montava, Juan García Valero, Olatz Landeta, Gorka Basañez, Rodrigo J Carbajo, Antonio Pineda-Lucena, Jordi Bujons, Alejandra Moure, Angel Messeguer, Carmen Lagunas, Carmen Herrero, Enrique Pérez-Payá
Published 2014-01-01