Active fragments from pro- and antiapoptotic BCL-2 proteins have distinct membrane behavior reflecting their functional divergence.

by Yannis Guillemin, Jonathan Lopez, Diana Gimenez, Gustavo Fuertes, Juan Garcia Valero, Loïc Blum, Philippe Gonzalo, Jesùs Salgado, Agnès Girard-Egrot, Abdel Aouacheria
Published 2010-01-01

µ-Calpain conversion of antiapoptotic Bfl-1 (BCL2A1) into a prodeath factor reveals two distinct alpha-helices inducing mitochondria-mediated apoptosis.

by Juan García Valero, Aurélie Cornut-Thibaut, Romain Jugé, Anne-Laure Debaud, Diana Giménez, Germain Gillet, Nathalie Bonnefoy-Bérard, Jesús Salgado, Gilles Salles, Abdel Aouacheria, Jérôme Kucharczak
Published 2012-01-01

Whi2 is a conserved negative regulator of TORC1 in response to low amino acids.

by Xianghui Chen, Guiqin Wang, Yu Zhang, Margaret Dayhoff-Brannigan, Nicola L Diny, Mingjun Zhao, Ge He, Cierra N Sing, Kyle A Metz, Zachary D Stolp, Abdel Aouacheria, Wen-Chih Cheng, J Marie Hardwick, Xinchen Teng
Published 2018-08-01