Genetic Testing and Risk Scores: Impact on Familial Hypercholesterolemia

by Ashish Sarraju, Joshua W. Knowles, Joshua W. Knowles, Joshua W. Knowles
Published 2019-01-01

Cardiovascular disease: The rise of the genetic risk score.

by Joshua W Knowles, Euan A Ashley
Published 2018-03-01

Health disparities in cardiometabolic risk among Black and Hispanic youth in the United States

by Sophia Figueroa Katz, Fatima Rodriguez, Joshua W. Knowles
Published 2021-06-01

Generation of two heterozygous MYBPC3 mutation-carrying human iPSC lines, SCVIi001-A and SCVIi002-A, for modeling hypertrophic cardiomyopathy

by Lichao Liu, Sushma P. Shenoy, James W.S. Jahng, Yu Liu, Joshua W. Knowles, Yan Zhuge, Joseph C. Wu
Published 2021-05-01

The role of insulin as a key regulator of seeding, proliferation, and mRNA transcription of human pluripotent stem cells

by Mohammad Shahbazi, Paige Cundiff, Wenyu Zhou, Philip Lee, Achchhe Patel, Sunita L. D’Souza, Fahim Abbasi, Thomas Quertermous, Joshua W. Knowles
Published 2019-07-01

Simple, standardized incorporation of genetic risk into non-genetic risk prediction tools for complex traits: coronary heart disease as an example

by Benjamin A Goldstein, Joshua W Knowles, Elias eSalfati, John PA Ioannidis, John PA Ioannidis, John PA Ioannidis, Themistocles Leonard Assimes
Published 2014-08-01

CRISPR-Cas9-mediated knockout of SPRY2 in human hepatocytes leads to increased glucose uptake and lipid droplet accumulation

by Naomi L. Cook, Milos Pjanic, Andrew G. Emmerich, Abhiram S. Rao, Susanne Hetty, Joshua W. Knowles, Thomas Quertermous, Casimiro Castillejo-López, Erik Ingelsson
Published 2019-10-01

Association of insulin resistance, from mid-life to late-life, with aortic stiffness in late-life: the Atherosclerosis Risk in Communities Study

by Anna K. Poon, Michelle L. Meyer, Hirofumi Tanaka, Elizabeth Selvin, James Pankow, Donglin Zeng, Laura Loehr, Joshua W. Knowles, Wayne Rosamond, Gerardo Heiss
Published 2020-01-01

Nat1 Deficiency Is Associated with Mitochondrial Dysfunction and Exercise Intolerance in Mice

by Indumathi Chennamsetty, Michael Coronado, Kévin Contrepois, Mark P. Keller, Ivan Carcamo-Orive, John Sandin, Giovanni Fajardo, Andrew J. Whittle, Mohsen Fathzadeh, Michael Snyder, Gerald Reaven, Alan D. Attie, Daniel Bernstein, Thomas Quertermous, Joshua W. Knowles
Published 2016-10-01

Predictive network modeling in human induced pluripotent stem cells identifies key driver genes for insulin responsiveness.

by Ivan Carcamo-Orive, Marc Y R Henrion, Kuixi Zhu, Noam D Beckmann, Paige Cundiff, Sara Moein, Zenan Zhang, Melissa Alamprese, Sunita L D'Souza, Martin Wabitsch, Eric E Schadt, Thomas Quertermous, Joshua W Knowles, Rui Chang
Published 2020-12-01

Impact of a Genetic Risk Score for Coronary Artery Disease on Reducing Cardiovascular Risk: A Pilot Randomized Controlled Study

by Joshua W. Knowles, Shirin Zarafshar, Aleksandra Pavlovic, Benjamin A. Goldstein, Sandra Tsai, Sandra Tsai, Jin Li, Michael V. McConnell, Devin Absher, Euan A. Ashley, Euan A. Ashley, Michaela Kiernan, John P. A. Ioannidis, John P. A. Ioannidis, John P. A. Ioannidis, Themistocles L. Assimes
Published 2017-08-01

FAM13A affects body fat distribution and adipocyte function

by Mohsen Fathzadeh, Jiehan Li, Abhiram Rao, Naomi Cook, Indumathi Chennamsetty, Marcus Seldin, Xiang Zhou, Panjamaporn Sangwung, Michael J. Gloudemans, Mark Keller, Allan Attie, Jing Yang, Martin Wabitsch, Ivan Carcamo-Orive, Yuko Tada, Aldons J. Lusis, Myung Kyun Shin, Cliona M. Molony, Tracey McLaughlin, Gerald Reaven, Stephen B. Montgomery, Dermot Reilly, Thomas Quertermous, Erik Ingelsson, Joshua W. Knowles
Published 2020-03-01

Genomic integrity of human induced pluripotent stem cells across nine studies in the NHLBI NextGen program

by Kanika Kanchan, Kruthika Iyer, Lisa R Yanek, Ivan Carcamo-Orive, Margaret A Taub, Claire Malley, Kristin Baldwin, Lewis C Becker, Ulrich Broeckel, Linzhao Cheng, Chad Cowan, Matteo D'Antonio, Kelly A Frazer, Thomas Quertermous, Gustavo Mostoslavsky, George Murphy, Marlene Rabinovitch, Daniel J Rader, Martin H Steinberg, Eric Topol, Wenli Yang, Joshua W Knowles, Cashell E Jaquish, Ingo Ruczinski, Rasika A Mathias
Published 2020-07-01

Precision screening for familial hypercholesterolaemia: a machine learning study applied to electronic health encounter data

by Kelly D Myers, BS, Joshua W Knowles, MD, David Staszak, PhD, Michael D Shapiro, DO, William Howard, PhD, Mrinal Yadava, MD, David Zuzick, MBA, Latoya Williamson, MS, Nigam H Shah, PhD, Juan M Banda, PhD, Joe Leader, BS, William C Cromwell, MD, Ed Trautman, PhD, Michael F Murray, ProfMD, Seth J Baum, MD, Seth Myers, PhD, Samuel S Gidding, MD, Katherine Wilemon, BS, Daniel J Rader, ProfMD
Published 2019-12-01

Phased whole-genome genetic risk in a family quartet using a major allele reference sequence.

by Frederick E Dewey, Rong Chen, Sergio P Cordero, Kelly E Ormond, Colleen Caleshu, Konrad J Karczewski, Michelle Whirl-Carrillo, Matthew T Wheeler, Joel T Dudley, Jake K Byrnes, Omar E Cornejo, Joshua W Knowles, Mark Woon, Katrin Sangkuhl, Li Gong, Caroline F Thorn, Joan M Hebert, Emidio Capriotti, Sean P David, Aleksandra Pavlovic, Anne West, Joseph V Thakuria, Madeleine P Ball, Alexander W Zaranek, Heidi L Rehm, George M Church, John S West, Carlos D Bustamante, Michael Snyder, Russ B Altman, Teri E Klein, Atul J Butte, Euan A Ashley
Published 2011-09-01