The mouse resistance protein Irgm1 (LRG-47): a regulator or an effector of pathogen defense?

by Julia P Hunn, Jonathan C Howard
Published 2010-01-01

A dedicated promoter drives constitutive expression of the cell-autonomous immune resistance GTPase, Irga6 (IIGP1) in mouse liver.

by Jia Zeng, Iana Angelova Parvanova, Jonathan C Howard
Published 2009-08-01

Modeling infectious disease in mice: co-adaptation and the role of host-specific IFNgamma responses.

by Jörn Coers, Michael N Starnbach, Jonathan C Howard
Published 2009-05-01

Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouse

by Jingtao Lilue, Urs Benedikt Müller, Tobias Steinfeldt, Jonathan C Howard
Published 2013-10-01

Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunity-related GTPases (IRG proteins) triggers necrotic cell death.

by Yang O Zhao, Aliaksandr Khaminets, Julia P Hunn, Jonathan C Howard
Published 2009-02-01

Localisation and mislocalisation of the interferon-inducible immunity-related GTPase, Irgm1 (LRG-47) in mouse cells.

by Yang O Zhao, Stephanie Könen-Waisman, Gregory A Taylor, Sascha Martens, Jonathan C Howard
Published 2010-01-01

Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases.

by Sascha Martens, Iana Parvanova, Jens Zerrahn, Gareth Griffiths, Gudrun Schell, Gaby Reichmann, Jonathan C Howard
Published 2005-11-01

Identification of the microsporidian Encephalitozoon cuniculi as a new target of the IFNγ-inducible IRG resistance system.

by Marialice da Fonseca Ferreira-da-Silva, Helen Maria Springer-Frauenhoff, Wolfgang Bohne, Jonathan C Howard
Published 2014-10-01

A Toxoplasma gondii pseudokinase inhibits host IRG resistance proteins.

by Martin C Fleckenstein, Michael L Reese, Stephanie Könen-Waisman, John C Boothroyd, Jonathan C Howard, Tobias Steinfeldt
Published 2012-01-01

Correction: Phosphorylation of Mouse Immunity-Related GTPase (IRG) Resistance Proteins Is an Evasion Strategy for Virulent Toxoplasma gondii.

by Tobias Steinfeldt, Stephanie Könen-Waisman, Lan Tong, Nikolaus Pawlowski, Tobias Lamkemeyer, L David Sibley, Julia P Hunn, Jonathan C Howard
Published 2015-07-01

Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondii.

by Tobias Steinfeldt, Stephanie Könen-Waisman, Lan Tong, Nikolaus Pawlowski, Tobias Lamkemeyer, L David Sibley, Julia P Hunn, Jonathan C Howard
Published 2010-12-01

UNC93B1 mediates host resistance to infection with Toxoplasma gondii.

by Mariane B Melo, Pia Kasperkovitz, Anna Cerny, Stephanie Könen-Waisman, Evelyn A Kurt-Jones, Egil Lien, Bruce Beutler, Jonathan C Howard, Douglas T Golenbock, Ricardo T Gazzinelli
Published 2010-08-01

Death and resurrection of the human IRGM gene.

by Cemalettin Bekpen, Tomas Marques-Bonet, Can Alkan, Francesca Antonacci, Maria Bruna Leogrande, Mario Ventura, Jeffrey M Kidd, Priscillia Siswara, Jonathan C Howard, Evan E Eichler
Published 2009-03-01

Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice

by Mateo Murillo-León, Urs B. Müller, Ines Zimmermann, Shishir Singh, Pia Widdershooven, Cláudia Campos, Catalina Alvarez, Stephanie Könen-Waisman, Nahleen Lukes, Zsolt Ruzsics, Jonathan C. Howard, Martin Schwemmle, Tobias Steinfeldt
Published 2019-03-01

Author Correction: Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice

by Mateo Murillo-León, Urs B. Müller, Ines Zimmermann, Shishir Singh, Pia Widdershoven, Claudia Campos, Catalina Alvarez, Stephanie Könen-Waisman, Nahleen Lukes, Zsolt Ruzsics, Jonathan C. Howard, Martin Schwemmle, Tobias Steinfeldt
Published 2019-04-01

The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens.

by Oliver Liesenfeld, Iana Parvanova, Jens Zerrahn, Seong-Ji Han, Frederik Heinrich, Melba Muñoz, Frank Kaiser, Toni Aebischer, Thorsten Buch, Ari Waisman, Gaby Reichmann, Olaf Utermöhlen, Esther von Stebut, Friederike D von Loewenich, Christian Bogdan, Sabine Specht, Michael Saeftel, Achim Hoerauf, Maria M Mota, Stephanie Könen-Waisman, Stefan H E Kaufmann, Jonathan C Howard
Published 2011-01-01

Comparative genomics of the apicomplexan parasites Toxoplasma gondii and Neospora caninum: Coccidia differing in host range and transmission strategy.

by Adam James Reid, Sarah J Vermont, James A Cotton, David Harris, Grant A Hill-Cawthorne, Stephanie Könen-Waisman, Sophia M Latham, Tobias Mourier, Rebecca Norton, Michael A Quail, Mandy Sanders, Dhanasekaran Shanmugam, Amandeep Sohal, James D Wasmuth, Brian Brunk, Michael E Grigg, Jonathan C Howard, John Parkinson, David S Roos, Alexander J Trees, Matthew Berriman, Arnab Pain, Jonathan M Wastling
Published 2012-01-01