Loss of Proprotein Convertase Furin in Mammary Gland Impairs proIGF1R and proIR Processing and Suppresses Tumorigenesis in Triple Negative Breast Cancer

by Zongsheng He, Abdel-Majid Khatib, John W. M. Creemers
Published 2020-09-01

Differential Effects of <i>Furin</i> Deficiency on Insulin Receptor Processing and Glucose Control in Liver and Pancreatic β Cells of Mice

by Ilaria Coppola, Bas Brouwers, Sandra Meulemans, Bruno Ramos-Molina, John W. M. Creemers
Published 2021-06-01

The dwarf phenotype in GH240B mice, haploinsufficient for the autism candidate gene Neurobeachin, is caused by ectopic expression of recombinant human growth hormone.

by Kim Nuytens, Krizia Tuand, Quili Fu, Pieter Stijnen, Vincent Pruniau, Sandra Meulemans, Hugo Vankelecom, John W M Creemers
Published 2014-01-01

Functional and clinical relevance of novel and known PCSK1 variants for childhood obesity and glucose metabolism

by Dennis Löffler, Susanne Behrendt, John W.M. Creemers, Jürgen Klammt, Gabriela Aust, Juraj Stanik, Wieland Kiess, Peter Kovacs, Antje Körner
Published 2017-03-01

In Vivo Analysis of the Contribution of Proprotein Convertases to the Processing of FGF23

by Omar Al Rifai, Omar Al Rifai, Delia Susan-Resiga, Rachid Essalmani, John W. M. Creemers, Nabil G. Seidah, Mathieu Ferron, Mathieu Ferron, Mathieu Ferron, Mathieu Ferron
Published 2021-06-01

Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth

by Jeroen Declercq, Bas Brouwers, Vincent P. E. G. Pruniau, Pieter Stijnen, Krizia Tuand, Sandra Meulemans, Annik Prat, Nabil G. Seidah, Abdel-Majid Khatib, John W. M. Creemers
Published 2015-01-01

Metabolic and Behavioural Phenotypes in Nestin-Cre Mice Are Caused by Hypothalamic Expression of Human Growth Hormone.

by Jeroen Declercq, Bas Brouwers, Vincent P E G Pruniau, Pieter Stijnen, Geoffroy de Faudeur, Krizia Tuand, Sandra Meulemans, Lutgarde Serneels, Anica Schraenen, Frans Schuit, John W M Creemers
Published 2015-01-01

Haploinsufficiency of the autism candidate gene Neurobeachin induces autism-like behaviors and affects cellular and molecular processes of synaptic plasticity in mice

by Kim Nuytens, Ilse Gantois, Pieter Stijnen, Emilia Iscru, Annelies Laeremans, Lutgarde Serneels, Lien Van Eylen, Stephen A. Liebhaber, Koen Devriendt, Detlef Balschun, Lutgarde Arckens, John W.M. Creemers, Rudi D'Hooge
Published 2013-03-01