Protective immunity induced with the RTS,S/AS vaccine is associated with IL-2 and TNF-α producing effector and central memory CD4 T cells.

by Joanne M Lumsden, Robert J Schwenk, Lisa E Rein, Philippe Moris, Michel Janssens, Opokua Ofori-Anyinam, Joe Cohen, Kent E Kester, D Gray Heppner, Urszula Krzych
Published 2011-01-01

Heterologous prime-boost regimens with a recombinant chimpanzee adenoviral vector and adjuvanted F4 protein elicit polyfunctional HIV-1-specific T-Cell responses in macaques.

by Clarisse Lorin, Yannick Vanloubbeeck, Sébastien Baudart, Michaël Ska, Babak Bayat, Geoffroy Brauers, Géraldine Clarinval, Marie-Noëlle Donner, Martine Marchand, Marguerite Koutsoukos, Pascal Mettens, Joe Cohen, Gerald Voss
Published 2015-01-01

Insights into long-lasting protection induced by RTS,S/AS02A malaria vaccine: further results from a phase IIb trial in Mozambican children.

by Caterina Guinovart, John J Aponte, Jahit Sacarlal, Pedro Aide, Amanda Leach, Quique Bassat, Eusébio Macete, Carlota Dobaño, Marc Lievens, Christian Loucq, W Ripley Ballou, Joe Cohen, Pedro L Alonso
Published 2009-01-01

Circumsporozoite-specific T cell responses in children vaccinated with RTS,S/AS01E and protection against P falciparum clinical malaria.

by Ally Olotu, Philippe Moris, Jedidah Mwacharo, Johan Vekemans, Domtila Kimani, Michel Janssens, Oscar Kai, Erik Jongert, Marc Lievens, Amanda Leach, Tonya Villafana, Barbara Savarese, Kevin Marsh, Joe Cohen, Philip Bejon
Published 2011-01-01

Safety, immunogenicity and duration of protection of the RTS,S/AS02(D) malaria vaccine: one year follow-up of a randomized controlled phase I/IIb trial.

by Pedro Aide, John J Aponte, Montse Renom, Tacilta Nhampossa, Jahit Sacarlal, Inacio Mandomando, Quique Bassat, Maria Nélia Manaca, Amanda Leach, Marc Lievens, Johan Vekemans, Marie-Claude Dubois, Christian Loucq, W Ripley Ballou, Joe Cohen, Pedro L Alonso
Published 2010-11-01

A randomized trial assessing the safety and immunogenicity of AS01 and AS02 adjuvanted RTS,S malaria vaccine candidates in children in Gabon.

by Bertrand Lell, Selidji Agnandji, Isabelle von Glasenapp, Sonja Haertle, Sunny Oyakhiromen, Saadou Issifou, Johan Vekemans, Amanda Leach, Marc Lievens, Marie-Claude Dubois, Marie-Ange Demoitie, Terrell Carter, Tonya Villafana, W Ripley Ballou, Joe Cohen, Peter G Kremsner
Published 2009-10-01

Induction of Plasmodium falciparum-specific CD4+ T cells and memory B cells in Gabonese children vaccinated with RTS,S/AS01(E) and RTS,S/AS02(D).

by Selidji T Agnandji, Rolf Fendel, Michaël Mestré, Michel Janssens, Johan Vekemans, Jana Held, Ferdinand Gnansounou, Sonja Haertle, Isabel von Glasenapp, Sunny Oyakhirome, Ludovic Mewono, Philippe Moris, Marc Lievens, Marie-Ange Demoitie, Patrice M Dubois, Tonya Villafana, Erik Jongert, Aurelie Olivier, Joe Cohen, Meral Esen, Peter G Kremsner, Bertrand Lell, Benjamin Mordmüller
Published 2011-04-01

Strain-specific Plasmodium falciparum growth inhibition among Malian children immunized with a blood-stage malaria vaccine.

by Matthew B Laurens, Bourema Kouriba, Elke Bergmann-Leitner, Evelina Angov, Drissa Coulibaly, Issa Diarra, Modibo Daou, Amadou Niangaly, William C Blackwelder, Yukun Wu, Joe Cohen, W Ripley Ballou, Johan Vekemans, David E Lanar, Sheetij Dutta, Carter Diggs, Lorraine Soisson, D Gray Heppner, Ogobara K Doumbo, Christopher V Plowe, Mahamadou A Thera
Published 2017-01-01

Evaluation of RTS,S/AS02A and RTS,S/AS01B in adults in a high malaria transmission area.

by Mark E Polhemus, Shon A Remich, Bernhards R Ogutu, John N Waitumbi, Lucas Otieno, Stella Apollo, James F Cummings, Kent E Kester, Christian F Ockenhouse, Ann Stewart, Opokua Ofori-Anyinam, Isabelle Ramboer, Conor P Cahill, Marc Lievens, Marie-Claude Dubois, Marie-Ange Demoitie, Amanda Leach, Joe Cohen, W Ripley Ballou, D Gray Heppner
Published 2009-07-01

Safety and immunogenicity of a recombinant Plasmodium falciparum AMA1 malaria vaccine adjuvanted with Alhydrogel, Montanide ISA 720 or AS02.

by Meta Roestenberg, Ed Remarque, Erik de Jonge, Rob Hermsen, Hildur Blythman, Odile Leroy, Egeruan Imoukhuede, Soren Jepsen, Opokua Ofori-Anyinam, Bart Faber, Clemens H M Kocken, Miranda Arnold, Vanessa Walraven, Karina Teelen, Will Roeffen, Quirijn de Mast, W Ripley Ballou, Joe Cohen, Marie Claude Dubois, Stéphane Ascarateil, Andre van der Ven, Alan Thomas, Robert Sauerwein
Published 2008-01-01

Phase 1/2a Trial of Plasmodium vivax Malaria Vaccine Candidate VMP001/AS01B in Malaria-Naive Adults: Safety, Immunogenicity, and Efficacy.

by Jason W Bennett, Anjali Yadava, Donna Tosh, Jetsumon Sattabongkot, Jack Komisar, Lisa A Ware, William F McCarthy, Jessica J Cowden, Jason Regules, Michele D Spring, Kristopher Paolino, Joshua D Hartzell, James F Cummings, Thomas L Richie, Joanne Lumsden, Edwin Kamau, Jittawadee Murphy, Cynthia Lee, Falgunee Parekh, Ashley Birkett, Joe Cohen, W Ripley Ballou, Mark E Polhemus, Yannick F Vanloubbeeck, Johan Vekemans, Christian F Ockenhouse
Published 2016-02-01

Correction: Safety of the Malaria Vaccine Candidate, RTS,S/AS01E in 5 to 17 Month Old Kenyan and Tanzanian Children

by John Lusingu, Ally Olotu, Amanda Leach, Marc Lievens, Johan Vekemans, Aurélie Olivier, Sarah Benns, Raimos Olomi, Salum Msham, Trudie Lang, Jayne Gould, Karin Hallez, Yolanda Guerra, Patricia Njuguna, Ken O. Awuondo, Anangisye Malabeja, Omar Abdul, Samwel Gesase, Denise Dekker, Lincoln Malle, Sadiki Ismael, Neema Mturi, Chris J. Drakeley, Barbara Savarese, Tonya Villafana, W. Ripley Ballou, Joe Cohen, Eleanor M. Riley, Martha M. Lemnge, Kevin Marsh, Philip Bejon, Lorenz von Seidlein
Published 2010-01-01

Correction: Safety of the Malaria Vaccine Candidate, RTS,S/AS01E in 5 to 17 Month Old Kenyan and Tanzanian Children

by John Lusingu, Ally Olotu, Amanda Leach, Marc Lievens, Johan Vekemans, Aurélie Olivier, Sarah Benns, Raimos Olomi, Salum Msham, Trudie Lang, Jayne Gould, Karin Hallez, Yolanda Guerra, Patricia Njuguna, Ken O. Awuondo, Anangisye Malabeja, Omar Abdul, Samwel Gesase, Denise Dekker, Lincoln Malle, Sadiki Ismael, Neema Mturi, Chris J. Drakeley, Barbara Savarese, Tonya Villafana, W. Ripley Ballou, Joe Cohen, Eleanor M. Riley, Martha M. Lemnge, Kevin Marsh, Philip Bejon, Lorenz von Seidlein
Published 2010-01-01

Correction: Safety of the Malaria Vaccine Candidate, RTS,S/AS01 in 5 to 17 Month Old Kenyan and Tanzanian Children.

by John Lusingu, Ally Olotu, Amanda Leach, Marc Lievens, Johan Vekemans, Aurélie Olivier, Sarah Benns, Raimos Olomi, Salum Msham, Trudie Lang, Jayne Gould, Karin Hallez, Yolanda Guerra, Patricia Njuguna, Ken O. Awuondo, Anangisye Malabeja, Omar Abdul, Samwel Gesase, Denise Dekker, Lincoln Malle, Sadiki Ismael, Neema Mturi, Chris J. Drakeley, Barbara Savarese, Tonya Villafana, W. Ripley Ballou, Joe Cohen, Eleanor M. Riley, Martha M. Lemnge, Kevin Marsh, Philip Bejon, Lorenz von Seidlein
Published 2010-01-01

Safety of the malaria vaccine candidate, RTS,S/AS01E in 5 to 17 month old Kenyan and Tanzanian Children.

by John Lusingu, Ally Olotu, Amanda Leach, Marc Lievens, Johan Vekemans, Aurélie Olivier, Sarah Benns, Raimos Olomi, Salum Msham, Trudie Lang, Jayne Gould, Karin Hallez, Yolanda Guerra, Patricia Njuguna, Ken O Awuondo, Anangisye Malabeja, Omar Abdul, Samwel Gesase, Denise Dekker, Lincoln Malle, Sadiki Ismael, Neema Mturi, Chris J Drakeley, Barbara Savarese, Tonya Villafana, W Ripley Ballou, Joe Cohen, Eleanor M Riley, Martha M Lemnge, Kevin Marsh, Philip Bejon, Lorenz von Seidlein
Published 2010-11-01

Correction: Safety of the Malaria Vaccine Candidate, RTS,S/AS01 in 5 to 17 Month Old Kenyan and Tanzanian Children.

by John Lusingu, Ally Olotu, Amanda Leach, Marc Lievens, Johan Vekemans, Aurélie Olivier, Sarah Benns, Raimos Olomi, Salum Msham, Trudie Lang, Jayne Gould, Karin Hallez, Yolanda Guerra, Patricia Njuguna, Ken O. Awuondo, Anangisye Malabeja, Omar Abdul, Samwel Gesase, Denise Dekker, Lincoln Malle, Sadiki Ismael, Neema Mturi, Chris J. Drakeley, Barbara Savarese, Tonya Villafana, W. Ripley Ballou, Joe Cohen, Eleanor M. Riley, Martha M. Lemnge, Kevin Marsh, Philip Bejon, Lorenz von Seidlein
Published 2010-01-01

T cell responses to the RTS,S/AS01(E) and RTS,S/AS02(D) malaria candidate vaccines administered according to different schedules to Ghanaian children.

by Daniel Ansong, Kwaku P Asante, Johan Vekemans, Sandra K Owusu, Ruth Owusu, Naana A W Brobby, David Dosoo, Alex Osei-Akoto, Kingsley Osei-Kwakye, Emmanuel Asafo-Adjei, Kwadwo O Boahen, Justice Sylverken, George Adjei, David Sambian, Stephen Apanga, Kingsley Kayan, Michel H Janssens, Marc J J Lievens, Aurelie C Olivier, Erik Jongert, Patrice Dubois, Barbara M Savarese, Joe Cohen, Sampson Antwi, Brian M Greenwood, Jennifer A Evans, Tsiri Agbenyega, Philippe J Moris, Seth Owusu-Agyei
Published 2011-04-01

Blood stage malaria vaccine eliciting high antigen-specific antibody concentrations confers no protection to young children in Western Kenya.

by Bernhards R Ogutu, Odika J Apollo, Denise McKinney, Willis Okoth, Joram Siangla, Filip Dubovsky, Kathryn Tucker, John N Waitumbi, Carter Diggs, Janet Wittes, Elissa Malkin, Amanda Leach, Lorraine A Soisson, Jessica B Milman, Lucas Otieno, Carolyn A Holland, Mark Polhemus, Shon A Remich, Christian F Ockenhouse, Joe Cohen, W Ripley Ballou, Samuel K Martin, Evelina Angov, V Ann Stewart, Jeffrey A Lyon, D Gray Heppner, Mark R Withers, MSP-1 Malaria Vaccine Working Group
Published 2009-01-01

Ad35.CS.01-RTS,S/AS01 Heterologous Prime Boost Vaccine Efficacy against Sporozoite Challenge in Healthy Malaria-Naïve Adults.

by Christian F Ockenhouse, Jason Regules, Donna Tosh, Jessica Cowden, April Kathcart, James Cummings, Kristopher Paolino, James Moon, Jack Komisar, Edwin Kamau, Thomas Oliver, Austin Chhoeu, Jitta Murphy, Kirsten Lyke, Matthew Laurens, Ashley Birkett, Cynthia Lee, Rich Weltzin, Ulrike Wille-Reece, Martha Sedegah, Jenny Hendriks, Isabella Versteege, Maria Grazia Pau, Jerold Sadoff, Yannick Vanloubbeeck, Marc Lievens, Dirk Heerwegh, Philippe Moris, Yolanda Guerra Mendoza, Erik Jongert, Joe Cohen, Gerald Voss, W Ripley Ballou, Johan Vekemans
Published 2015-01-01

Correction: Randomized Controlled Trial of RTS,S/AS02D and RTS,S/AS01E Malaria Candidate Vaccines Given According to Different Schedules in Ghanaian Children

by Seth Owusu-Agyei, Daniel Ansong, Kwaku Asante, Sandra Kwarteng Owusu, Ruth Owusu, Naana Ayiwa Wireko Brobby, David Dosoo, Alex Osei Akoto, Kingsley Osei-Kwakye, Emmanuel Asafo Adjei, Kwadwo Owusu Boahen, Justice Sylverken, George Adjei, David Sambian, Stephen Apanga, Kingsley Kayan, Johan Vekemans, Opokua Ofori-Anyinam, Amanda Leach, Marc Lievens, Marie-Ange Demoitie, Marie-Claude Dubois, Joe Cohen, W. Ripley Ballou, Barbara Savarese, Daniel Chandramohan, John Owusu Gyapong, Paul Milligan, Sampson Antwi, Tsiri Agbenyega, Brian Greenwood, Jennifer Evans
Published 2010-01-01