Biofilm formation by staphylococci and streptococci: structural, functional and regulatory aspects and implications for pathogenesis

by Pietro eSpeziale, Joan A Geoghegan
Published 2015-04-01

The Role of Staphylococcus aureus Virulence Factors in Skin Infection and Their Potential as Vaccine Antigens

by Keenan A. Lacey, Joan A. Geoghegan, Rachel M. McLoughlin
Published 2016-02-01

Protein-based biofilm matrices in Staphylococci

by Pietro eSpeziale, Giampiero ePietrocola, Timothy J Foster, Joan A Geoghegan
Published 2014-12-01

Clumping factor B is an important virulence factor during Staphylococcus aureus skin infection and a promising vaccine target.

by Keenan A Lacey, Michelle E Mulcahy, Aisling M Towell, Joan A Geoghegan, Rachel M McLoughlin
Published 2019-04-01

Lessons from the Crystal Structure of the S. aureus Surface Protein Clumping Factor A in Complex With Tefibazumab, an Inhibiting Monoclonal Antibody

by Vannakambadi K. Ganesh, Xiaowen Liang, Joan A. Geoghegan, Ana Luisa V. Cohen, Nagarajan Venugopalan, Timothy J Foster, Magnus Hook
Published 2016-11-01

Molecular Characterization of the Multiple Interactions of SpsD, a Surface Protein from Staphylococcus pseudintermedius, with Host Extracellular Matrix Proteins.

by Giampiero Pietrocola, Joan A Geoghegan, Simonetta Rindi, Antonella Di Poto, Antonino Missineo, Valerio Consalvi, Timothy J Foster, Pietro Speziale
Published 2013-01-01

Force-Induced Strengthening of the Interaction between Staphylococcus aureus Clumping Factor B and Loricrin

by Pauline Vitry, Claire Valotteau, Cécile Feuillie, Simon Bernard, David Alsteens, Joan A. Geoghegan, Yves F. Dufréêne, Matthew R. Parsek
Published 2017-12-01

Adhesion of Staphylococcus aureus to Corneocytes from Atopic Dermatitis Patients Is Controlled by Natural Moisturizing Factor Levels

by Cécile Feuillie, Pauline Vitry, Maeve A. McAleer, Sanja Kezic, Alan D. Irvine, Joan A. Geoghegan, Yves F. Dufrêne
Published 2018-08-01

Host-specialized fibrinogen-binding by a bacterial surface protein promotes biofilm formation and innate immune evasion.

by Amy C Pickering, Pauline Vitry, Valeriia Prystopiuk, Brandon Garcia, Magnus Höök, Jeffrey Schoenebeck, Joan A Geoghegan, Yves F Dufrêne, J Ross Fitzgerald
Published 2019-06-01

Nasal colonisation by Staphylococcus aureus depends upon clumping factor B binding to the squamous epithelial cell envelope protein loricrin.

by Michelle E Mulcahy, Joan A Geoghegan, Ian R Monk, Kate M O'Keeffe, Evelyn J Walsh, Timothy J Foster, Rachel M McLoughlin
Published 2012-12-01

Staphylococcus aureus surface protein SdrE binds complement regulator factor H as an immune evasion tactic.

by Julia A Sharp, Charlene G Echague, Pamela S Hair, Michael D Ward, Julius O Nyalwidhe, Joan A Geoghegan, Timothy J Foster, Kenji M Cunnion
Published 2012-01-01

Mobile-Genetic-Element-Encoded Hypertolerance to Copper Protects Staphylococcus aureus from Killing by Host Phagocytes

by Marta Zapotoczna, Gustavo P. Riboldi, Ahmed M. Moustafa, Elizabeth Dickson, Apurva Narechania, Julie A. Morrissey, Paul J. Planet, Matthew T. G. Holden, Kevin J. Waldron, Joan A. Geoghegan
Published 2018-10-01

Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin

by Samir Olatunji, Xiaoxiao Yu, Jonathan Bailey, Chia-Ying Huang, Marta Zapotoczna, Katherine Bowen, Maja Remškar, Rolf Müller, Eoin M. Scanlan, Joan A. Geoghegan, Vincent Olieric, Martin Caffrey
Published 2020-01-01

Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection.

by Aisling F Brown, Alison G Murphy, Stephen J Lalor, John M Leech, Kate M O'Keeffe, Micheál Mac Aogáin, Dara P O'Halloran, Keenan A Lacey, Mehri Tavakol, Claire H Hearnden, Deirdre Fitzgerald-Hughes, Hilary Humphreys, Jérôme P Fennell, Willem J van Wamel, Timothy J Foster, Joan A Geoghegan, Ed C Lavelle, Thomas R Rogers, Rachel M McLoughlin
Published 2015-01-01