Apoptosis induction by MEK inhibition in human lung cancer cells is mediated by Bim.

by Jieru Meng, Bingliang Fang, Yong Liao, Christine M Chresta, Paul D Smith, Jack A Roth
Published 2010-09-01

The tumor suppressor gene TUSC2 (FUS1) sensitizes NSCLC to the AKT inhibitor MK2206 in LKB1-dependent manner.

by Jieru Meng, Mourad Majidi, Bingliang Fang, Lin Ji, B Nebiyou Bekele, John D Minna, Jack A Roth
Published 2013-01-01

Combination treatment with MEK and AKT inhibitors is more effective than each drug alone in human non-small cell lung cancer in vitro and in vivo.

by Jieru Meng, Bingbing Dai, Bingliang Fang, B Nebiyou Bekele, William G Bornmann, Duoli Sun, Zhenghong Peng, Roy S Herbst, Vassiliki Papadimitrakopoulou, John D Minna, Michael Peyton, Jack A Roth
Published 2010-11-01