Homology Modeling Informs Ligand Discovery for the Glutamine Transporter ASCT2

by Rachel-Ann A. Garibsingh, Nicholas J. Otte, Nicholas J. Otte, Elias Ndaru, Claire Colas, Christof Grewer, Jeff Holst, Jeff Holst, Avner Schlessinger
Published 2018-07-01

EGF-activated PI3K/Akt signalling coordinates leucine uptake by regulating LAT3 expression in prostate cancer

by Blake K. Zhang, Anne M. Moran, Charles G. Bailey, John E. J. Rasko, Jeff Holst, Qian Wang
Published 2019-07-01

Identifying microRNA determinants of human myelopoiesis

by Megha Rajasekhar, Ulf Schmitz, Stephane Flamant, Justin J.-L. Wong, Charles G. Bailey, William Ritchie, Jeff Holst, John E. J. Rasko
Published 2018-05-01

Ligand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual Screening.

by Claire Colas, Christof Grewer, Nicholas James Otte, Armanda Gameiro, Thomas Albers, Kurnvir Singh, Helen Shere, Massimiliano Bonomi, Jeff Holst, Avner Schlessinger
Published 2015-10-01

The antiproliferative ELF2 isoform, ELF2B, induces apoptosis in vitro and perturbs early lymphocytic development in vivo

by Fiona H. X. Guan, Charles G. Bailey, Cynthia Metierre, Patrick O’Young, Dadi Gao, Teh Liane Khoo, Jeff Holst, John E. J. Rasko
Published 2017-03-01

Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways

by Michelle van Geldermalsen, Lake-Ee Quek, Nigel Turner, Natasha Freidman, Angel Pang, Yi Fang Guan, James R. Krycer, Renae Ryan, Qian Wang, Jeff Holst
Published 2018-06-01

Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment

by Justin J. -L. Wong, Dadi Gao, Trung V. Nguyen, Chau-To Kwok, Michelle van Geldermalsen, Rob Middleton, Natalia Pinello, Annora Thoeng, Rajini Nagarajah, Jeff Holst, William Ritchie, John E. J. Rasko
Published 2017-05-01

A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth

by Joanna L Gillis, Josephine A Hinneh, Natalie K Ryan, Swati Irani, Max Moldovan, Lake-Ee Quek, Raj K Shrestha, Adrienne R Hanson, Jianling Xie, Andrew J Hoy, Jeff Holst, Margaret M Centenera, Ian G Mills, David J Lynn, Luke A Selth, Lisa M Butler
Published 2021-08-01

Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis

by Zeyad D Nassar, Chui Yan Mah, Jonas Dehairs, Ingrid JG Burvenich, Swati Irani, Margaret M Centenera, Madison Helm, Raj K Shrestha, Max Moldovan, Anthony S Don, Jeff Holst, Andrew M Scott, Lisa G Horvath, David J Lynn, Luke A Selth, Andrew J Hoy, Johannes V Swinnen, Lisa M Butler
Published 2020-07-01