Effect of spermidine on misfolding and interactions of alpha-synuclein.

by Alexey V Krasnoslobodtsev, Jie Peng, Josephat M Asiago, Jagadish Hindupur, Jean-Christophe Rochet, Yuri L Lyubchenko
Published 2012-01-01

Effects of impaired membrane interactions on α-synuclein aggregation and neurotoxicity

by Daniel Ysselstein, Mehul Joshi, Vartika Mishra, Amy M. Griggs, Josephat M. Asiago, George P. McCabe, Lia A. Stanciu, Carol Beth Post, Jean-Christophe Rochet
Published 2015-07-01

Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways

by Annadurai Anandhan, Humberto Rodriguez-Rocha, Iryna Bohovych, Amy M. Griggs, Laura Zavala-Flores, Elsa M. Reyes-Reyes, Javier Seravalli, Lia A. Stanciu, Jaekwon Lee, Jean-Christophe Rochet, Oleh Khalimonchuk, Rodrigo Franco
Published 2015-09-01

Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein

by Natalie Landeck, Katherine E. Strathearn, Daniel Ysselstein, Kerstin Buck, Sayan Dutta, Siddhartha Banerjee, Zhengjian Lv, John D. Hulleman, Jagadish Hindupur, Li-Kai Lin, Sonal Padalkar, Lia A. Stanciu, Yuri L. Lyubchenko, Deniz Kirik, Jean-Christophe Rochet
Published 2020-09-01

DJ-1 can form β-sheet structured aggregates that co-localize with pathological amyloid deposits

by Katalin Solti, Wei-Li Kuan, Balázs Fórizs, Gergely Kustos, Judith Mihály, Zoltán Varga, Balázs Herberth, Éva Moravcsik, Róbert Kiss, Manuela Kárpáti, Anna Mikes, Yanyan Zhao, Tímea Imre, Jean-Christophe Rochet, Franklin Aigbirhio, Caroline H. Williams-Gray, Roger A. Barker, Gergely Tóth
Published 2020-02-01

Corrigendum to 'DJ-1 can form β-sheet structured aggregates that co-localize with pathological amyloid deposits'. Neurobiology of Disease 134 (2020) 104629

by Katalin Solti, Wei-Li Kuan, Balázs Fórizs, Gergely Kustos, Judith Mihály, Zoltán Varga, Balázs Herberth, Éva Moravcsik, Róbert Kiss, Manuela Kárpáti, Anna Mikes, Yanyan Zhao, Tímea Imre, Jean-Christophe Rochet, Franklin Aigbirhio, Caroline H. Williams-Gray, Roger A. Barker, Gergely Tóth
Published 2020-08-01

Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form

by Timothy J. Collier, Kinshuk R. Srivastava, Craig Justman, Tom Grammatopoulous, Birgit Hutter-Paier, Manuela Prokesch, Daniel Havas, Jean-Christophe Rochet, Fang Liu, Kevin Jock, Patrícia de Oliveira, Georgia L. Stirtz, Ulf Dettmer, Caryl E. Sortwell, Mel B. Feany, Peter Lansbury, Lisa Lapidus, Katrina L. Paumier
Published 2017-10-01

Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease.

by Gergely Tóth, Shyra J Gardai, Wagner Zago, Carlos W Bertoncini, Nunilo Cremades, Susan L Roy, Mitali A Tambe, Jean-Christophe Rochet, Celine Galvagnion, Gaia Skibinski, Steven Finkbeiner, Michael Bova, Karin Regnstrom, San-San Chiou, Jennifer Johnston, Kari Callaway, John P Anderson, Michael F Jobling, Alexander K Buell, Ted A Yednock, Tuomas P J Knowles, Michele Vendruscolo, John Christodoulou, Christopher M Dobson, Dale Schenk, Lisa McConlogue
Published 2014-01-01