Specialty Grand Challenge for Molecular Signalling and Pathways in Molecular Neuroscience

by Jean-Marc Taymans
Published 2021-05-01

Alpha-Synuclein and Lipids: The Elephant in the Room?

by Alessia Sarchione, Antoine Marchand, Jean-Marc Taymans, Marie-Christine Chartier-Harlin
Published 2021-09-01

Mind the Gap: LRRK2 Phenotypes in the Clinic vs. in Patient Cells

by Liesel Goveas, Eugénie Mutez, Marie-Christine Chartier-Harlin, Jean-Marc Taymans
Published 2021-04-01

LRRK2 Phosphorylation, More Than an Epiphenomenon

by Antoine Marchand, Antoine Marchand, Matthieu Drouyer, Matthieu Drouyer, Alessia Sarchione, Alessia Sarchione, Marie-Christine Chartier-Harlin, Marie-Christine Chartier-Harlin, Jean-Marc Taymans, Jean-Marc Taymans
Published 2020-06-01

The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson’s Disease

by Hardy J. Rideout, Marie-Christine Chartier-Harlin, Marie-Christine Chartier-Harlin, Matthew J. Fell, Warren D. Hirst, Sarah Huntwork-Rodriguez, Cheryl E. G. Leyns, Omar S. Mabrouk, Jean-Marc Taymans, Jean-Marc Taymans
Published 2020-08-01

In Vitro Phosphorylation Does not Influence the Aggregation Kinetics of WT α-Synuclein in Contrast to Its Phosphorylation Mutants

by Sarah Schreurs, Melanie Gerard, Rita Derua, Etienne Waelkens, Jean-Marc Taymans, Veerle Baekelandt, Yves Engelborghs
Published 2014-01-01

The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation.

by Azad Kumar, Elisa Greggio, Alexandra Beilina, Alice Kaganovich, Diane Chan, Jean-Marc Taymans, Benjamin Wolozin, Mark R Cookson
Published 2010-01-01

LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding.

by Jean-Marc Taymans, Renée Vancraenenbroeck, Petri Ollikainen, Alexandra Beilina, Evy Lobbestael, Marc De Maeyer, Veerle Baekelandt, Mark R Cookson
Published 2011-01-01

PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2

by Laura Civiero, Susanna Cogo, Susanna Cogo, Anneleen Kiekens, Claudia Morganti, Isabella Tessari, Evy Lobbestael, Veerle Baekelandt, Jean-Marc Taymans, Jean-Marc Taymans, Marie-Christine Chartier-Harlin, Marie-Christine Chartier-Harlin, Cinzia Franchin, Cinzia Franchin, Giorgio Arrigoni, Giorgio Arrigoni, Patrick A. Lewis, Giovanni Piccoli, Luigi Bubacco, Mark R. Cookson, Paolo Pinton, Elisa Greggio
Published 2017-12-01

Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes

by Kushal Sejwal, Mohamed Chami, Hervé Rémigy, Renée Vancraenenbroeck, William Sibran, Rosmarie Sütterlin, Paul Baumgartner, Robert McLeod, Marie-Christine Chartier-Harlin, Veerle Baekelandt, Henning Stahlberg, Jean-Marc Taymans
Published 2017-08-01

Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers.

by Laura Civiero, Renée Vancraenenbroeck, Elisa Belluzzi, Alexandra Beilina, Evy Lobbestael, Lauran Reyniers, Fangye Gao, Ivan Micetic, Marc De Maeyer, Luigi Bubacco, Veerle Baekelandt, Mark R Cookson, Elisa Greggio, Jean-Marc Taymans
Published 2012-01-01

Role of LRRK2 in the regulation of dopamine receptor trafficking.

by Mauro Rassu, Maria Grazia Del Giudice, Simona Sanna, Jean Marc Taymans, Michele Morari, Alberto Brugnoli, Martina Frassineti, Alessandra Masala, Sonia Esposito, Manuela Galioto, Cristiana Valle, Maria Teresa Carri, Alice Biosa, Elisa Greggio, Claudia Crosio, Ciro Iaccarino
Published 2017-01-01

Protein phosphatase 2A holoenzymes regulate leucine-rich repeat kinase 2 phosphorylation and accumulation

by Matthieu Drouyer, Marc F. Bolliger, Evy Lobbestael, Chris Van den Haute, Marco Emanuele, Réginald Lefebvre, William Sibran, Tina De Wit, Coline Leghay, Eugénie Mutez, Nicolas Dzamko, Glenda M. Halliday, Shigeo Murayama, Alain Martoriati, Katia Cailliau, Jean-François Bodart, Marie-Christine Chartier-Harlin, Veerle Baekelandt, R. Jeremy Nichols, Jean-Marc Taymans
Published 2021-09-01

The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo

by Noémie Cresto, Camille Gardier, Marie-Claude Gaillard, Francesco Gubinelli, Pauline Roost, Daniela Molina, Charlène Josephine, Noëlle Dufour, Gwenaëlle Auregan, Martine Guillermier, Suéva Bernier, Caroline Jan, Pauline Gipchtein, Philippe Hantraye, Marie-Christine Chartier-Harlin, Gilles Bonvento, Nadja Van Camp, Jean-Marc Taymans, Karine Cambon, Géraldine Liot, Alexis-Pierre Bemelmans, Emmanuel Brouillet
Published 2021-06-01

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation

by Jesús Madero-Pérez, Elena Fdez, Belén Fernández, Antonio J. Lara Ordóñez, Marian Blanca Ramírez, Patricia Gómez-Suaga, Dieter Waschbüsch, Evy Lobbestael, Veerle Baekelandt, Angus C. Nairn, Javier Ruiz-Martínez, Ana Aiastui, Adolfo López de Munain, Pawel Lis, Thomas Comptdaer, Jean-Marc Taymans, Marie-Christine Chartier-Harlin, Alexandria Beilina, Adriano Gonnelli, Mark R. Cookson, Elisa Greggio, Sabine Hilfiker
Published 2018-01-01