Clocking the Pace of Organoid Research

by Jason R. Spence, PhD
Published 2017-07-01

Taming the Wild West of Organoids, Enteroids, and Mini-Guts

by Jason R. Spence, PhD
Published 2018-01-01

Gastrointestinal Organoids: Understanding the Molecular Basis of the HostâMicrobe InterfaceSummary

by David R. Hill, Jason R. Spence
Published 2017-03-01

Low-Level Mouse DNA in Conditioned Medium Generates False Positive Cross-Species Contamination Results in Human Organoid Cultures

by Margaret S. Bohm, Michael K. Dame, Joseph Boyd, Kevin Su, Angeline Wu, Durga Attili, Vi Chu, Justin A. Colacino, Justin A. Colacino, Justin A. Colacino, Jason R. Spence, Jason R. Spence, Jason R. Spence
Published 2020-11-01

A bioengineered niche promotes in vivo engraftment and maturation of pluripotent stem cell derived human lung organoids

by Briana R Dye, Priya H Dedhia, Alyssa J Miller, Melinda S Nagy, Eric S White, Lonnie D Shea, Jason R Spence
Published 2016-10-01

Hox5 Genes Regulate the Wnt2/2b-Bmp4-Signaling Axis during Lung Development

by Steven M. Hrycaj, Briana R. Dye, Nicholas C. Baker, Brian M. Larsen, Ann C. Burke, Jason R. Spence, Deneen M. Wellik
Published 2015-08-01

Sox17 regulates insulin secretion in the normal and pathologic mouse β cell.

by Diva Jonatan, Jason R Spence, Anna M Method, Matthew Kofron, Katie Sinagoga, Leena Haataja, Peter Arvan, Gail H Deutsch, James M Wells
Published 2014-01-01

Neural Crest Cell Implantation Restores Enteric Nervous System Function and Alters the Gastrointestinal Transcriptome in Human Tissue-Engineered Small Intestine

by Christopher R. Schlieve, Kathryn L. Fowler, Matthew Thornton, Sha Huang, Ibrahim Hajjali, Xiaogang Hou, Brendan Grubbs, Jason R. Spence, Tracy C. Grikscheit
Published 2017-09-01

LGR4 and LGR5 Function Redundantly During Human Endoderm DifferentiationSummary

by Yu-Hwai Tsai, David R. Hill, Namit Kumar, Sha Huang, Alana M. Chin, Briana R. Dye, Melinda S. Nagy, Michael P. Verzi, Jason R. Spence
Published 2016-09-01

A Dynamic WNT/β-CATENIN Signaling Environment Leads to WNT-Independent and WNT-Dependent Proliferation of Embryonic Intestinal Progenitor Cells

by Alana M. Chin, Yu-Hwai Tsai, Stacy R. Finkbeiner, Melinda S. Nagy, Emily M. Walker, Nicole J. Ethen, Bart O. Williams, Michele A. Battle, Jason R. Spence
Published 2016-11-01

In Vitro Induction and In Vivo Engraftment of Lung Bud Tip Progenitor Cells Derived from Human Pluripotent Stem Cells

by Alyssa J. Miller, David R. Hill, Melinda S. Nagy, Yoshiro Aoki, Briana R. Dye, Alana M. Chin, Sha Huang, Felix Zhu, Eric S. White, Vibha Lama, Jason R. Spence
Published 2018-01-01

Induced pluripotent stem cell-derived enteric neural crest cells repopulate human aganglionic tissue-engineered intestine to form key components of the enteric nervous system

by David F Chang, Samuel M Zuber, Elizabeth A Gilliam, Laura-Marie A Nucho, Gabriel Levin, Fengnan Wang, Anthony I Squillaro, Sha Huang, Jason R Spence, Tracy C Grikscheit
Published 2020-04-01

A Diallel of the Mouse Collaborative Cross Founders Reveals Strong Strain-Specific Maternal Effects on Litter Size

by John R. Shorter, Paul L. Maurizio, Timothy A. Bell, Ginger D. Shaw, Darla R. Miller, Terry J. Gooch, Jason S. Spence, Leonard McMillan, William Valdar, Fernando Pardo-Manuel de Villena
Published 2019-05-01

Effect of Cell Spreading on Rosette Formation by Human Pluripotent Stem Cell-Derived Neural Progenitor Cells

by Ryan F. Townshend, Yue Shao, Sicong Wang, Chari L. Cortez, Sajedeh Nasr Esfahani, Jason R. Spence, K. Sue O’Shea, Jianping Fu, Deborah L. Gumucio, Kenichiro Taniguchi, Kenichiro Taniguchi, Kenichiro Taniguchi
Published 2020-10-01

Efficient Generation and Transcriptomic Profiling of Human iPSC-Derived Pulmonary Neuroendocrine Cells

by Pooja Hor, Vasu Punj, Ben A. Calvert, Alessandra Castaldi, Alyssa J. Miller, Gianni Carraro, Barry R. Stripp, Steven L. Brody, Jason R. Spence, Justin K. Ichida, Amy L. Ryan (Firth), Zea Borok
Published 2020-05-01

Differentiation of human colon tissue in culture: Effects of calcium on trans-epithelial electrical resistance and tissue cohesive properties.

by Shannon D McClintock, Durga Attili, Michael K Dame, Aliah Richter, Sabrina S Silvestri, Maliha M Berner, Margaret S Bohm, Kateryna Karpoff, Caroline L McCarthy, Jason R Spence, James Varani, Muhammad N Aslam
Published 2020-01-01

De Novo Formation of Insulin-Producing “Neo-β Cell Islets” from Intestinal Crypts

by Yi-Ju Chen, Stacy R. Finkbeiner, Daniel Weinblatt, Matthew J. Emmett, Feven Tameire, Maryam Yousefi, Chenghua Yang, Rene Maehr, Qiao Zhou, Ruth Shemer, Yuval Dor, Changhong Li, Jason R. Spence, Ben Z. Stanger
Published 2014-03-01

Generation of tissue-engineered small intestine using embryonic stem cell-derived human intestinal organoids

by Stacy R. Finkbeiner, Jennifer J. Freeman, Minna M. Wieck, Wael El-Nachef, Christopher H. Altheim, Yu-Hwai Tsai, Sha Huang, Rachel Dyal, Eric S. White, Tracy C. Grikscheit, Daniel H. Teitelbaum, Jason R. Spence
Published 2015-11-01

In vitro generation of human pluripotent stem cell derived lung organoids

by Briana R Dye, David R Hill, Michael AH Ferguson, Yu-Hwai Tsai, Melinda S Nagy, Rachel Dyal, James M Wells, Christopher N Mayhew, Roy Nattiv, Ophir D Klein, Eric S White, Gail H Deutsch, Jason R Spence
Published 2015-03-01

Bacterial colonization stimulates a complex physiological response in the immature human intestinal epithelium

by David R Hill, Sha Huang, Melinda S Nagy, Veda K Yadagiri, Courtney Fields, Dishari Mukherjee, Brooke Bons, Priya H Dedhia, Alana M Chin, Yu-Hwai Tsai, Shrikar Thodla, Thomas M Schmidt, Seth Walk, Vincent B Young, Jason R Spence
Published 2017-11-01