Insights into the Structural Requirements of Potent Brassinosteroids as Vegetable Growth Promoters Using Second-Internode Elongation as Biological Activity: CoMFA and CoMSIA Studie...

by Karoll Ferrer-Pertuz, Luis Espinoza, Jaime Mella
Published 2017-12-01

3D-QSAR/CoMFA-Based Structure-Affinity/Selectivity Relationships of Aminoalkylindoles in the Cannabinoid CB1 and CB2 Receptors

by Jaime Mella-Raipán, Santiago Hernández-Pino, César Morales-Verdejo, David Pessoa-Mahana
Published 2014-03-01

Three-Dimensional Quantitative Structure-Activity Relationships (3D-QSAR) on a Series of Piperazine-Carboxamides Fatty Acid Amide Hydrolase (FAAH) Inhibitors as a Useful Tool for t...

by Marcos Lorca, Yudisladys Valdes, Hery Chung, Javier Romero-Parra, C. David Pessoa-Mahana, Jaime Mella
Published 2019-05-01

Antioxidant Capacity of Pure Compounds and Complex Mixtures Evaluated by the ORAC-Pyrogallol Red Assay in the Presence of Triton X-100 Micelles

by Camilo López-Alarcón, Eduardo Lissi, Carlos David Pessoa-Mahana, Jaime Mella-Raipán, Benjamin Rojano, Max Romero
Published 2010-09-01

Structure-Activity Relationships Based on 3D-QSAR CoMFA/CoMSIA and Design of Aryloxypropanol-Amine Agonists with Selectivity for the Human β3-Adrenergic Receptor and Anti-Obesity a...

by Marcos Lorca, Cesar Morales-Verdejo, David Vásquez-Velásquez, Juan Andrades-Lagos, Javier Campanini-Salinas, Jorge Soto-Delgado, Gonzalo Recabarren-Gajardo, Jaime Mella
Published 2018-05-01

2D-QSAR and 3D-QSAR/CoMSIA Studies on a Series of (R)-2-((2-(1H-Indol-2-yl)ethyl)amino)-1-Phenylethan-1-ol with Human β3-Adrenergic Activity

by Gastón Apablaza, Luisa Montoya, Cesar Morales-Verdejo, Marco Mellado, Mauricio Cuellar, Carlos F. Lagos, Jorge Soto-Delgado, Hery Chung, Carlos David Pessoa-Mahana, Jaime Mella
Published 2017-03-01

Novel <i>N</i>-Arylsulfonylindoles Targeted as Ligands of the 5-HT₆ Receptor. Insights on the Influence of C-5 Substitution on Ligand Affinity

by Loreto Arrieta-Rodríguez, Daniela Espinoza-Rosales, Gonzalo Vera, Young Hwa Cho, David Cabezas, David Vásquez-Velásquez, Jaime Mella-Raipán, Carlos F. Lagos, Gonzalo Recabarren-Gajardo
Published 2021-06-01

Design, synthesis, cytotoxicity and 3D-QSAR analysis of new 3,6-disubstituted-1,2,4,5-tetrazine derivatives as potential antitumor agents

by Álvaro Cañete-Molina, Christian Espinosa-Bustos, Marcos González-Castro, Mario Faúndez, Jaime Mella, Ricardo A. Tapia, Alan R. Cabrera, Iván Brito, Adam Aguirre, Cristian O. Salas
Published 2019-11-01

Extended N-Arylsulfonylindoles as 5-HT6 Receptor Antagonists: Design, Synthesis &amp; Biological Evaluation

by Gonzalo Vera, Carlos F. Lagos, Sebastián Almendras, Dan Hebel, Francisco Flores, Gissella Valle-Corvalán, C. David Pessoa-Mahana, Jaime Mella-Raipán, Rodrigo Montecinos, Gonzalo Recabarren-Gajardo
Published 2016-08-01

Promising 2,6,9-Trisubstituted Purine Derivatives for Anticancer Compounds: Synthesis, 3D-QSAR, and Preliminary Biological Assays

by Cristian O. Salas, Ana Maria Zarate, Vladimir Kryštof, Jaime Mella, Mario Faundez, Jose Brea, María Isabel Loza, Ivan Brito, Denisa Hendrychová, Radek Jorda, Alan R. Cabrera, Ricardo A. Tapia, Christian Espinosa-Bustos
Published 2019-12-01

A New Kind of Quinonic-Antibiotic Useful Against Multidrug-Resistant S. aureus and E. faecium Infections

by Javier Campanini-Salinas, Juan Andrades-Lagos, Gerardo Gonzalez Rocha, Duane Choquesillo-Lazarte, Soledad Bollo Dragnic, Mario Faúndez, Pedro Alarcón, Francisco Silva, Roberto Vidal, Edison Salas-Huenuleo, Marcelo Kogan, Jaime Mella, Gonzalo Recabarren Gajardo, David Vásquez-Velásquez
Published 2018-07-01

Synthesis, Docking, 3-D-Qsar, and Biological Assays of Novel Indole Derivatives Targeting Serotonin Transporter, Dopamine D2 Receptor, and Mao-A Enzyme: In the Pursuit for Potentia...

by Christopher Cerda-Cavieres, Gabriel Quiroz, Patricio Iturriaga-Vásquez, Julio Rodríguez-Lavado, Jazmín Alarcón-Espósito, Claudio Saitz, Carlos D. Pessoa-Mahana, Hery Chung, Ramiro Araya-Maturana, Jaime Mella-Raipán, David Cabezas, Claudia Ojeda-Gómez, Miguel Reyes-Parada, Hernán Pessoa-Mahana
Published 2020-10-01

Synthesis of Novel Nicotinic Ligands with Multimodal Action: Targeting Acetylcholine α4β2, Dopamine and Serotonin Transporters

by Juan Pablo González-Gutiérrez, Hernán Armando Pessoa-Mahana, Patricio Ernesto Iturriaga-Vásquez, Miguel Iván Reyes-Parada, Nicolas Esteban Guerra-Díaz, Martin Hodar-Salazar, Franco Viscarra, Pablo Paillali, Gabriel Núñez-Vivanco, Marcos Antonio Lorca-Carvajal, Jaime Mella-Raipán, María Carolina Zúñiga
Published 2019-10-01